Rapid and Environmentally‐Friendly Synthesis of Thiazolidinone Analogues in Deep Eutectic Solvent Complemented with Computational Studies DOI Creative Commons

Gobind Kumar,

Pule Seboletswe,

Nontobeko Gcabashe

et al.

ChemistryOpen, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

A greener, safer, and more efficient methodology for the synthesis of (Z)-5-benzylidene-2-thioxothiazolidin-4-ones (3 a-u) (Z)-5-benzylidenethiazolidine-2,4-diones (4 a-i) has been developed. The deep eutectic solvent (DES) ZnCl

Language: Английский

Green synthesis, in silico modeling, and biological evaluation of N-substituted (Z)-5-arylidene imidazolidine/thiazolidine-2,4-dione/4-thione derivatives catalyzed by Bu SO3H core–shell nanostructures DOI Creative Commons
Malihe Akhavan, Zohreh Esam,

Atefeh Mirshafa

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(32), P. 22916 - 22938

Published: Jan. 1, 2024

The newly designed magnetic nanocatalyst Fe 3 O 4 @CPTMS@guanidine–BuSO H in a one-pot multicomponent reaction is reported to obtain N -substituted ( Z )-5-arylidene imidazolidine/thiazolidine-2,4-dione/4-thione as highly selective antiproliferation agent.

Language: Английский

Citations

4
Discovery of a new hydrazone-oxamide hybrid capable of inducing necroptotic cell death in triple negative breast cancer cells DOI

R K Akhavan,

Sanaz Jabari Harsini,

Samira Shafiee

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108267 - 108267

Published: Feb. 14, 2025

Language: Английский

Citations

0
Identification of Furin Protease Small-Molecule Inhibitor with a 1,3-Thiazol-2-ylaminosulfonyl Scaffold DOI Creative Commons
Anja Kolarič, Vid Ravnik, Sara Štumpf

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 273 - 273

Published: Feb. 19, 2025

Background: Proteolytic cleavage of inactive pathogen proteins by furin is critical for their entry into human cells, and thus the SARS-CoV-2 spike protein was identified as a prerequisite virus binding subsequent infection cells in recent COVID-19 pandemic. We report water-aware structure-based protease inhibitor design study. Methods: Our efforts focused on biological evaluation small molecule inhibitors that emerged from conserved virtual screening campaign library compounds shared structural or physicochemical properties with known exhibiting newly recognized modes. Results: novel small-molecule 1,3-thiazol-2-ylaminosulfonyl scaffold. Namely, compound N-[4-(1,3-thiazol-2-ylaminosulfonyl)phenyl]-3-{(E)-5-[(2-methoxyphenyl)methylene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propionamide showed an IC50 value 17.58 μM, comparable to other published inhibitors. Conclusions: This could represent starting point further development non-peptidic, assist studies coronaviral pathogenesis.

Language: Английский

Citations

0
Synthesis of (Z)-3-Allyl-5-(4-nitrobenzylidene)-2-sulfanylidene-1,3-thiazolidin-4-one and Determination of Its Crystal Structure DOI Creative Commons

Bastien Moreno,

Isabelle Jourdain, Michael Knorr

et al.

Molbank, Journal Year: 2024, Volume and Issue: 2024(1), P. M1783 - M1783

Published: March 1, 2024

To extend the existing library of arylidenerhodanines which display a potential biological activity, 3-N-allylrhodanine 1 was condensed under Knoevenagel conditions with p-nitrobenzaldehyde in acetic acid to afford π-conjugated heterocyclic compound 3-allyl-5-(4-nitrobenzylidene)-2-sulfanylidene-1,3-thiazolidin-4-one 2. Compound 2 characterized by IR and NMR spectroscopy, its UV-vis spectrum compared that 3-allyl-5-(4-methoxybenzylidene)-2-sulfanylidene-1,3-thiazolidin-4-one 3. The molecular structure is ascertained single-crystal X-ray diffraction study performed at 100 K.

Language: Английский

Citations

3
What is the Reason That the Pharmacological Future of Chemotherapeutics in the Treatment of Lung Cancer Could Be Most Closely Related to Nanostructures? Platinum Drugs in Therapy of Non-Small and Small Cell Lung Cancer and Their Unexpected, Possible Interactions. The Review DOI Creative Commons

Kamil Szupryczyński,

Przemysław Czeleń, Tomasz Jeliński

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9503 - 9547

Published: Sept. 1, 2024

Over the course of several decades, anticancer treatment with chemotherapy drugs for lung cancer has not changed significantly. Unfortunately, this prolongs patient's life only by a few months, causing many side effects in human body. It also been proven that such as Cisplatin, Carboplatin, Oxaliplatin and others can react other substances containing an aromatic ring which nitrogen atom free electron group its structure. Thus, structures may have competitive effect on nucleobases DNA. Therefore, scientists are looking new drugs, but alternative ways delivering drug to site. Nanotechnology seems be great hope matter. Creating nanomedicine would reduce dose absolute minimum, thus limit toxic drug; it allow exclusion interactions compounds structure similar nucleobases; permit using so-called targeted bypassing healthy cells; introduction options, radiotherapy directly site; provide diagnostic possibilities. This article is review aims systematize knowledge regarding cancer, only. shows clear possibility chemotherapeutics nitrogenous bases possibilities nanostructures potential Platinum carriers, proves easily become medicinal product personalized medicine.

Language: Английский

Citations

1
(Z)-N-Carbamoyl-4-hydroxy-4-(4-methoxyphenyl)-2-oxobut-3-enamide DOI Creative Commons

Alexandra O. Derevnina,

Anastasia A. Andreeva, А. Н. Масливец

et al.

Molbank, Journal Year: 2024, Volume and Issue: 2024(3), P. M1844 - M1844

Published: June 29, 2024

The reaction of 5-(4-methoxyphenyl)furan-2,3-dione with urea in a 1:1 ratio when refluxed mixture 1,2-dichloroethane-DMSO gives (Z)-N-carbamoyl-4-hydroxy-4-(4-methoxyphenyl)-2-oxobut-3-enamide good yield. This compound was fully characterized.

Language: Английский

Citations

0
A Brief Review on Different Reactions of Rhodanine DOI
Paramita Das, Suman Ray

Journal of Heterocyclic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

ABSTRACT 2‐Thioxo‐4‐thiazolidinone which is trivially known as rhodanine a five‐membered heterocycle, containing sulfur and nitrogen atom at 1 3 positions, respectively. It very attractive class of compounds, because derivatization yields number molecules having multifarious application in medicinal chemistry biology. There are many derived from already being used commercially drug molecules. So owing to the importance field biology, comprehensive review familiarizing different derivatives parent molecule their syntheses highly warranted. In this review, we have broadly categorized reactions as; (a) Knoevenagel condensation through C‐5 active methylene group with carbonyl (b) nucleophilic attack on thioxo position 2 by aliphatic amines, (c) oxo conversion, (d) all other reactions. far, best our knowledge, no such literature accounts for kinds reported. Here, not only presented schemes various literatures, but discussed about advantages inadequacies that particular catalytic processes. Moreover, end article given own critical analysis these reports, based understanding experience.

Language: Английский

Citations

0
Rapid and Environmentally‐Friendly Synthesis of Thiazolidinone Analogues in Deep Eutectic Solvent Complemented with Computational Studies DOI Creative Commons

Gobind Kumar,

Pule Seboletswe,

Nontobeko Gcabashe

et al.

ChemistryOpen, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

A greener, safer, and more efficient methodology for the synthesis of (Z)-5-benzylidene-2-thioxothiazolidin-4-ones (3 a-u) (Z)-5-benzylidenethiazolidine-2,4-diones (4 a-i) has been developed. The deep eutectic solvent (DES) ZnCl

Language: Английский

Citations

0