International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12635 - 12635
Published: Nov. 25, 2024
The
pursuit
of
nutraceuticals
to
improve
the
quality
life
for
patients
with
neurodegenerative
conditions
is
a
dynamic
field
within
neuropharmacology.
Unfortunately,
many
that
show
promise
in
preclinical
studies
fail
demonstrate
significant
clinical
benefits
human
trials,
leading
their
exclusion
as
therapeutic
options.
This
discrepancy
may
stem
from
categorical
interpretation
and
results.
Basic
researchers
often
assume
non-human
experimental
animals
exhibit
less
phenotypic
variability
than
humans.
belief
overlooks
interindividual
phenotype
variation,
thereby
conclusions
being
drawn
experiments.
Consequently,
when
trials
are
conducted,
expect
similarly
conclusive
If
these
results
not
achieved,
nutraceutical
deemed
ineffective
use,
even
if
numerous
individuals
might
benefit.
In
our
study,
we
evaluated
whether
analyzing
similarity
through
non-categorical
methods
could
help
identify
rotenone
(ROT)-treated
rats
benefit
consuming
nano-emulsified
punicic
acid
(Nano-PSO),
prevention
"parkinsonism"
or
restoration
neurometabolic
function
inconsistent
across
individuals.
Our
findings
supported
this
hypothesis.
Nano-PSO
were
categorical;
however,
variance
allowed
us
ROT
varying
degrees
consumption.
Hence,
translational
potential
basic
science
testing
pharmaceutical
products
against
neurodegeneration
also
interpret
using
data
analysis
population
screening,
overall
outcomes
entire
internal
inconsistencies.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(19), P. 21221 - 21233
Published: May 1, 2024
Globally,
the
rise
in
neurodegenerative
issues
tandem
with
shifts
lifestyle
and
aging
population
has
prompted
a
search
for
effective
interventions.
Nutraceutical
compounds
have
emerged
as
promising
agents
addressing
these
challenges.
This
60-day
study
on
an
aluminum-induced
cognitive
impairment
rat
model
assessed
three
their
combinations:
probiotics
(Prob,
Lactobacillus
plantarum
[5
×
1010
CFU/day],
acidophilus
CFU/day]),
docosahexaenoic
acid
(DHA,
23.8
mg/day),
vitamin
D3
(VD3,
150
IU/day).
Behavioral
outcomes
were
evaluated
by
using
Morris
water
maze
novel
object
recognition
tests.
Glial
activation
was
through
immunofluorescence
analysis
of
GFAP/Iba1,
oxidative
stress
markers
brain
tissue
determined
measuring
levels
Malondialdehyde
(MDA)
Superoxide
dismutase
(SOD).
The
results
demonstrated
progressive
improvement
learning
memory
capacity.
aluminum
group
exhibited
poorest
performance
behavioral
test,
enhanced
GFAP/Iba1
activation,
elevated
markers.
Conversely,
DHA
+
Prob
VD3
treatment
best
maze.
combination
superior
maze,
accompanied
reduced
DG/CA1
regions.
Furthermore,
supplementation
showed
lower
CA3
region
antioxidant
activity.
In
summary,
supplementing
various
nutraceutical
combinations,
including
DHA,
VD3,
Prob,
displayed
notable
benefits
against
impairment.
These
encompassed
enhancement,
diminished
MDA
concentration,
increased
SOD
activity,
glial
indicated
Nutrition and Dietary Supplements,
Journal Year:
2025,
Volume and Issue:
Volume 17, P. 19 - 28
Published: Feb. 1, 2025
Introduction:
Stress
and
inflammation
in
the
early
stages
of
cognitive
decline
has
spurred
interest
use
antioxidants
as
prophylactic
therapeutic
agents.
Several
studies
have
established
neuroprotective
capacities
a
pomegranate
oil
nano-formulation
(Nano-PSO).
In
parallel,
cannabis-derived
cannabidiol
(CBD)
prevented
social
recognition
deficits
reduced
neuroinflammation
mice.
This
work
assessed
impact
Nano-PSO:CBD
on
memory
learning.
Methods:
A
battery
hemp
extracts
was
screened
for
their
effects
acetylcholine
esterase
inhibition
neuronal
protection
activities.
The
best-performing
extract
in-vitro
assays
nano-formulated
via
self-emulsifying
system
with
PSO
administered
to
aged
mice
MK-801-induced
decline,
which
were
then
subjected
Morris
water
maze
test
Y-maze
test,
respectively.
Results:
Aged
chronically
fed
performed
22–
31%
shorter
escape
latency
(p
≤
0.05),
23%
distance
swam
increased
average
speed
compared
control
Mice
pretreated
prior
MK-801
had
significantly
higher
percentage
entries
into
novel
arm
untreated
controls.
Discussion:
CBD
salutary
effect
memory,
learning
spatial
should
be
further
studied
clinical
context.
Keywords:
cognition,
nanoformulation,
CBD,
seed
oil,
nano-omega
5,
brain
protect,
punicic
acid
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12594 - 12594
Published: Nov. 23, 2024
A
common
hallmark
of
neurodegenerative
diseases
is
the
accumulation
polypeptide
aggregates
in
neurons.
Despite
primary
cause
these
being
inherently
genetic,
their
development
can
be
delayed
with
proper
preventive
treatments.
Long-chain
polyunsaturated
fatty
acids
(ω-3
LCPUFA)
are
promising
bioactive
nutrients
that
beneficial
for
brain
health.
In
this
study,
impact
an
oil
rich
a
structured
form
docosahexaenoic
acid
(DHA)
triglyceride
(TG)
was
assessed
Caenorhabditis
elegans
model
expressing
long
poly-glutamine
(polyQ)
chains,
which
mimics
symptomatology
polyQ-related
such
as
Huntington’s
disease
(HD),
among
others.
The
lifespan,
motility,
number
polyQ
aggregates,
oxidative
stress
resistance,
and
cognitive
performance
associated
sensitive
stimuli
measured
mutant
nematodes
aggregates.
Overall,
DHA-TG
at
0.5
µM
improved
nematodes,
emphasizing
protection
against
serotonergic
synapse
dysfunction.
Furthermore,
treatment
reduced
nematodes.
data
described
herein
shed
light
on
connection
between
DHA
demonstrated
potential
nutritional
co-adjuvant
to
prevent
polyQ-associated
dysfunctions.
