Synthesis, antimicrobial, DNA binding, and computational studies of some bis- and poly(4-methyl-2H-chromen-2-one) derivatives DOI

Ibrahim M. Z. Fares,

Mohamed A. Ragheb, Ismail A. Abdelhamid

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140790 - 140790

Published: Nov. 1, 2024

Language: Английский

Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene moieties: induction of apoptosis in MCF7 and HEP2 cells DOI Creative Commons

Nada S. Ibrahim,

Hager Ahmed Sayed,

Marwa Sharaky

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 10091 - 10107

Published: July 9, 2024

Abstract Eight Novel chalcones were synthesized and their structures confirmed by different spectral tools. All the prepared compounds subjected to SRB cytotoxic screening against several cancer cell lines. Compound 5c exerted most promising effect MCF7 HEP2 cells with IC 50 values of 9.5 12 µg/mL, respectively. Real-time PCR demonstrated inhibitory compound on expression level Antigen kiel 67 (KI-67), Survivin, Interleukin-1beta ( IL-1B ) , Interleukin-6 IL-6 ), Cyclooxygenase-2 (COX-2 Protein kinase B (AKT1) genes. Flow-cytometric analysis cycle indicated that stopped at G0/G1 G2/M phases in treated cells, ELISA assay showed Caspase 8, 9, P53, BAX, Glutathione (GSH) extremely activated Matrix metalloproteinase 2 (MMP2), 9 (MMP9), BCL2, Malondialdehyde (MDA), deactivated cells. Wound healing revealed chalcone reduced ability close scrape wound decreased number migrating compared untreated after 48 h. Theoretical molecular modeling P53 mutant Y220C Bcl2 binding energies -22.8 -24.2 Kcal/mole, respectively, which our results.

Language: Английский

Citations

9
Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens DOI Creative Commons

Mona M. Soliman,

Ahmed H. M. Elwahy, Ahmed M. Sayed

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

1
Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer DOI Creative Commons
Nesma Abdelaal, Mohamed A. Ragheb, Hamdi M. Hassaneen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 4, 2024

Language: Английский

Citations

7
A practical and environmentally sustainable approach to dye removal: Synthesis and characterization of a highly efficient crosslinked chitosan-Schiff base adsorbent for Eriochrome Black T removal DOI
Magda F. Mohamed,

Amira A. Hamed,

Alaa A. Kashmiry

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142048 - 142048

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis, molecular docking simulation, and antimicrobial activities of novel fused pyrimidine systems linked to N-arylacetamide and vanillin units as novel hybrid molecules via Hantzsch and Biginelli reactions DOI

Ibrahim M. Z. Fares,

Mostafa E. Salem,

Merihan Saad Shafik

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142345 - 142345

Published: April 1, 2025

Language: Английский

Citations

0
One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo[3',2':1,2]pyrimido[4,5-b]quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl-2-mercaptoacetamides as precursors DOI Creative Commons

Rania Samy Omar,

Amr M. Abdelmoniem,

Ahmed H. M. Elwahy

et al.

ARKIVOC, Journal Year: 2024, Volume and Issue: 2024(8)

Published: July 4, 2024

New thiazolo[3',2':1,2]pyrimido [4,5-b]quinolines were synthesized in good yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and one mole each of 6-aminothiouracil 5,5dimethyl-1,3-cyclohexanedione.The identical compounds might also be generated by alkylating relevant 5-aryl-2-thioxopyrimido[4,5-b]quinoline-4,6-diones with matching 2-chloro-N-arylacetamide.A feasible mechanistic approach to production target products was proposed.

Language: Английский

Citations

2
New Class of Thienopyridines: Design, Synthesis, Antimicrobial Activity and Molecular Docking Study DOI
Azhaar T. Alsaggaf, Mostafa Sayed,

Ahmed A . Dewan

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1323, P. 140741 - 140741

Published: Nov. 14, 2024

Language: Английский

Citations

2
Synthesis, antimicrobial, DNA binding, and computational studies of some bis- and poly(4-methyl-2H-chromen-2-one) derivatives DOI

Ibrahim M. Z. Fares,

Mohamed A. Ragheb, Ismail A. Abdelhamid

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140790 - 140790

Published: Nov. 1, 2024

Language: Английский

Citations

2