Bioelectricity, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)
Published: Oct. 17, 2024
The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.
Language: Английский
Citations
10
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)
Published: Aug. 15, 2024
Abstract Bionic electrical stimulation (Bio‐ES) aims to achieve personalized therapy and proprioceptive adaptation by mimicking natural neural signatures of the body, while current Bio‐ES devices are reliant on complex sensing computational simulation systems, thus often limited low‐fidelity simulated signals, failure interface information interaction due mechanical mismatch between soft tissues rigid electrodes. Here, study presents a flexible ultrathin self‐sustainable bioelectronic patch (Bio‐patch), which can self‐adhere lesion area organs generate bionic signals synchronized vagal nerve envelope in situ implement Bio‐ES. It allows adaptive adjustment intensity, frequency, waveform fully meet needs tissue regeneration based real‐time feedback from controlled organs. With this foundation, Bio‐patch effectively intervene with excessive fibrosis microvascular stasis during healing process regulating polarization time macrophages, promoting reconstruction tissue‐engineered structure, accelerating repair damaged liver kidney. This work develops practical approach realize biomimetic electronic modulation growth development only using multifunctional Bio‐patch, establishes new paradigm for precise medicine.
Language: Английский
Citations
8
Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37192 - e37192
Published: Aug. 30, 2024
In immunology, the role of macrophages extends far beyond their traditional classification as mere phagocytes; they emerge pivotal architects immune response, with function being significantly influenced by multidimensional environmental stimuli. This review investigates nuanced mechanisms which diverse external signals ranging from chemical cues to physical stress orchestrate macrophage polarization, a process that is crucial for modulation responses. By transitioning between pro-inflammatory (M1) and anti-inflammatory (M2) states, exhibit remarkable plasticity, enabling them adapt influence surroundings effectively. The exploration polarization provides compelling narrative on how these cells can be manipulated foster an environment conducive tissue repair regeneration. Highlighting cutting-edge research, this presents innovative strategies leverage dynamic interplay environment, proposing novel therapeutic avenues harness potential in regenerative medicine. Moreover, critically evaluates current challenges future prospects translating macrophage-centered laboratory clinical applications.
Language: Английский
Citations
6
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 711, P. 149911 - 149911
Published: April 7, 2024
Language: Английский
Citations
5
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Developing scaffolds supporting functional cell attachment and tissue growth is critical in basic research, engineering, regenerative medicine approaches. Though poly(ethylene glycol) (PEG) its derivatives are attractive for hydrogels scaffold fabrication, they often require bioactive modifications due to their bioinert nature. In this work, biomimetic synthesized conductive polypyrrole-poly(3,4-ethylenedioxythiophene) copolymer doped with poly(styrenesulfonate) (PPy-PEDOT:PSS) was used as a biocompatible coating diacrylate (PEGDA) hydrogel support neuronal muscle cells' attachment, activity, differentiation. The characterized by Raman spectroscopy dynamic light scattering. Its electrochemical properties were studied using galvanostatic charge-discharge (GCD) voltammetry. PPy-PEDOT:PSS-coated atomic force microscopy, protein adsorption assessed quartz crystal microbalance dissipation monitoring. Attachment differentiation of the ND7/23 neuron hybrid line C2C12 myoblasts evaluated cytoskeleton staining quantification morphological parameters. Viability live/dead flow cytometry. Cortex neural activity calcium ion influx that could be detected through fluorescence changes Fluo-4. PPy-PEDOT:PSS supported nontoxic cells. Primary neurons attached remained responsive electrical stimulation. Altogether, simple yet effective alternative presents great potential an interface nervous other electrically excitable tissues.
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: 11(2), P. 784 - 805
Published: Jan. 30, 2025
Myocardial infarction (MI), a severe cardiovascular condition, is typically triggered by coronary artery disease, resulting in ischemic damage and the subsequent necrosis of myocardium. Macrophages, known for their remarkable plasticity, are capable exhibiting range phenotypes functions as they react to diverse stimuli within local microenvironment. In recent years, there has been an increasing number studies on regulation macrophage behavior based tissue engineering strategies, its regulatory mechanisms deserve further investigation. This review first summarizes effects key factors engineered biomaterials (including bioactive molecules, conductivity, some microenvironmental factors) behavior, then explores specific methods inducing through materials promote myocardial repair, role macrophage-host cell crosstalk regulating inflammation, vascularization, remodeling. Finally, we propose future challenges macrophage-material interactions tailoring personalized guide phenotypes.
Language: Английский
Citations
0
Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Language: Английский
Citations
0
Electronics, Journal Year: 2025, Volume and Issue: 14(7), P. 1376 - 1376
Published: March 29, 2025
A chronic wound is a that fails to progress through the normal stages of healing within typical time frame, often remaining open and unhealed for more than 4 6 weeks. The delayed associated with comorbidities, its clinical consequences have posed great concern patients, caregivers, researchers. use electrostimulation enhance in wounds has received attention last 20 years. Innovative wearable electroceutical devices are engineered while prioritizing patient convenience. These employ controlled micro-electrostimulation reactivate endogenous bioelectric activities needed cellular signaling. However, these their mechanisms not been fully explored. In this systematic review, three databases articles published between 2000 2023 were searched screened using strict inclusion criteria adhering PRISMA checklist. We identified direct, pulsed, alternating electric currents as primary modalities by deliver electrical stimulation wounds. Typical include diabetic foot ulcers, pressure venous ulcers. Additionally, few materials crucial reviewed, recent research considered study. Various devices, including triboelectric piezo-nanogenerators, potential functionalities generating relevant applications. literature lacked closed-loop platforms treatment concurrent monitoring healing. analysis taken from review provides opportunities at intersection epidermal soft bioelectronics, care, remote sensing.
Language: Английский
Citations
0
BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 176, P. 01010 - 01010
Published: Jan. 1, 2025
As part of its commitment to the Paris Agreement and addressing climate change, Indonesia has submitted first Nationally Determined Contribution (NDC) is now preparing Second NDC with more ambitious targets, incorporating a broader focus on blue carbon sector. Achieving these goals requires strengthening stakeholder engagement within This study employs comprehensive bibliometric analysis, followed by Systematic Literature Review (SLR), assess in sector identify relevant knowledge. The findings reveal that only thirteen articles were identified, significant concentration studies from Australia. research also compares four selected countries— United States, Australia, Philippines, Indonesia— context carbon, based insights extracted six key articles. identifies similarities both approaches engagement.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7272 - 7272
Published: July 2, 2024
A macrophage shift from the M1 to M2 phenotype is relevant for promoting tissue repair and regeneration. In a previous in vivo study, we found that direct current (DC) electrical stimulation (EStim) increased proportion of macrophages healing tissues directed balance injury response away healing/scarring towards These observations led us hypothesize DC EStim regulates polarization an phenotype. THP-1-derived M0, (IFN-γ LPS), (IL-4 IL-13) were exposed (or not: control group) 100 mV/mm EStim, 1 h/day three days. Macrophage was assessed through gene surface marker expressions cytokine secretion profiles. Following treatment, M0 cells exhibited upregulation genes IL10, CD163, PPARG. cells, upregulated markers TGM2, CD206 downregulated CD86. treatment also reduced expression CD86 pro-inflammatory cytokines IL-1β IL-6. Our results suggest differentially exerts pro-M2 effects depending on phenotype: it upregulates typical while inhibiting at nuclear protein levels interleukins cells. Conversely, appear be less responsive employed this study.
Language: Английский
Citations
3