Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions DOI Creative Commons
Mostafa E. Salem,

Yassmen A. El-Gabry,

Ismail A. Abdelhamid

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 5, 2024

Molecular hybridization is a technique used in drug creation that involves combining the pharmacophoric moieties of multiple bioactive compounds to create new hybrid molecule with better affinity and effectiveness. In this regard, we created unique molecules out diphenyl ether-linked fused pyrans other heterocycles. The Michael reaction 4,4'-oxydibenzaldehyde malononitrile various active methylene derivatives, as well enaminone produced matching bis-fused pyridines, both connected ether moiety. Furthermore, acid-catalyzed dimedone or β-naphthol corresponding bis(hexahydro-1

Language: Английский

Synthesis and antibacterial activities of novel hybrid molecules based on benzothiazole, benzimidazole, benzoxazole, and pyrimidine derivatives, each connected to N-arylacetamide and benzoate groups DOI
Ahmed H. M. Elwahy,

Hadeel F. Hammad,

Nada S. Ibrahim

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1307, P. 137965 - 137965

Published: March 5, 2024

Language: Английский

Citations

9
Synthesis, molecular docking, and antimicrobial activity of novel scaffolds based on bis(thiazole) linked to 2-phenoxy-N-arylacetamide as new hybrid molecules DOI

Abbas H. Abdullah,

Nada S. Ibrahim,

Faisal K. Algethami

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1302, P. 137506 - 137506

Published: Jan. 7, 2024

Language: Английский

Citations

7
Exploring quinoxaline derivatives: An overview of a new approach to combat antimicrobial resistance DOI
Hena Khatoon, Siti Munirah Mohd Faudzi

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116675 - 116675

Published: July 14, 2024

Language: Английский

Citations

4
Synthesis, molecular docking simulation, and antimicrobial activities of novel fused pyrimidine systems linked to N-arylacetamide and vanillin units as novel hybrid molecules via Hantzsch and Biginelli reactions DOI

Ibrahim M. Z. Fares,

Mostafa E. Salem,

Merihan Saad Shafik

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142345 - 142345

Published: April 1, 2025

Language: Английский

Citations

0
Quinoxaline clubbed thiazole: Molecular docking, synthesis and antimicrobial evaluation DOI
Sagar Ramdas Shrimandilkar, Pravin Tatyaram Tryambake,

Keshao Abasaheb Mahale

et al.

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: 101(7), P. 101163 - 101163

Published: April 30, 2024

Language: Английский

Citations

3
Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions DOI Creative Commons
Mostafa E. Salem,

Yassmen A. El-Gabry,

Ismail A. Abdelhamid

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 5, 2024

Molecular hybridization is a technique used in drug creation that involves combining the pharmacophoric moieties of multiple bioactive compounds to create new hybrid molecule with better affinity and effectiveness. In this regard, we created unique molecules out diphenyl ether-linked fused pyrans other heterocycles. The Michael reaction 4,4'-oxydibenzaldehyde malononitrile various active methylene derivatives, as well enaminone produced matching bis-fused pyridines, both connected ether moiety. Furthermore, acid-catalyzed dimedone or β-naphthol corresponding bis(hexahydro-1

Language: Английский

Citations

2