Results in Chemistry, Journal Year: 2024, Volume and Issue: 11, P. 101854 - 101854
Published: Oct. 1, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106721 - 106721
Published: Feb. 1, 2025
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33792 - 33826
Published: Dec. 3, 2024
Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects
Language: Английский
Citations
6
BioNanoScience, Journal Year: 2024, Volume and Issue: 14(2), P. 1386 - 1396
Published: May 9, 2024
Language: Английский
Citations
5
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Ferulic acid (FA), a phenolic compound abundant in the cell walls of seeds, leaves, and roots various fruits, vegetables, cereals, grains, is renowned for its wide range biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. Despite therapeutic potential, clinical application FA hindered by challenges such as poor water solubility, limited bioavailability, rapid metabolism, instability under physiological conditions. To address these issues, nanotechnology has emerged transformative approach, enhancing FA's pharmacokinetic profile. Various nanoparticle-based systems, polymer-based lipid-based nanoparticles, have been developed to encapsulate FA. These systems demonstrated significant improvements stability, with studies showing enhanced antioxidant activity controlled release profiles. Further, surface engineering nanoparticles provides targeted drug/phytochemical delivery potential. The drugs/phytochemicals significantly enhances efficacy minimizes systemic side effects. This review explores potential FA, limitations application, advancements that are paving way effective use.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 16, 2025
In recent years, nanoparticle (NP) systems have demonstrated significant promise in pharmaceutical applications. This study focused on the development of donepezil hydrochloride-loaded PLGA-NPs, prepared using 'Double Emulsion Solvent Evaporation' method. The impact varying concentrations polyvinyl alcohol-(PVA) aqueous phase and sonication time NP characteristics was comprehensively examined. Results showed that increasing PVA concentration resulted a reduction size, with an optimal formulation (I-DNP) achieving particle size 136.37 nm ± 0.93 PDI 0.122 0.011, indicating uniformity. zeta potential measured at - 24.17mV 1.21, confirming electrostatic stability formulation, essential for long-term stability. Trehalose incorporated to enhance stability, gastrointestinal testing revealed I-DNP degraded faster acidic environments. encapsulation efficiency reached 69.22 4.84%, suggesting effective drug loading, release studies exhibited sustained profile, Fickian non-Fickian mechanism. DSC, FT-IR, 1H-NMR analyses confirmed structural integrity formulation. biological activity studies, potent anti-AChE anti-BuChE activities, Chorioallantoic Membrane (CAM) assays showing inhibition angiogenesis. These findings highlight as promising therapeutic strategy Alzheimer's disease, demonstrating its ability controlled release, blood-brain barrier (BBB) penetration. Future will focus vivo models further validate clinical applicability. research contributes advancement nanoparticle-based delivery neurodegenerative diseases, paving way innovative approaches.
Language: Английский
Citations
0
Results in Chemistry, Journal Year: 2024, Volume and Issue: 11, P. 101854 - 101854
Published: Oct. 1, 2024
Language: Английский
Citations
0