Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care
Adina Alberts,
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Elena-Theodora Moldoveanu,
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Adelina-Gabriela Niculescu
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et al.
Journal of Composites Science,
Journal Year:
2025,
Volume and Issue:
9(3), P. 133 - 133
Published: March 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Language: Английский
Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 271 - 271
Published: April 5, 2025
Collagen-based
wound
dressings
have
developed
as
an
essential
component
of
contemporary
care,
utilizing
collagen’s
inherent
properties
to
promote
healing.
This
review
thoroughly
analyzes
collagen
dressing
advances,
examining
different
formulations
such
hydrogels,
films,
and
foams
that
enhance
care.
The
important
processes
by
which
promotes
healing
(e.g.,
promoting
angiogenesis,
encouraging
cell
proliferation,
offering
structural
support)
are
discussed
clarify
its
function
in
tissue
regeneration.
effectiveness
adaptability
demonstrated
via
clinical
applications
investigated
acute
chronic
wounds.
Additionally,
commercially
accessible
collagen-based
skin
treatments
discussed,
demonstrating
their
practical
use
healthcare
settings.
Despite
the
progress,
study
discusses
obstacles
restrictions
encountered
producing
adopting
dressings,
difficulties
manufacturing
financial
concerns.
Finally,
current
landscape’s
insights
indicate
future
research
possibilities
for
optimization,
bioactive
agent
integration,
overcoming
existing
constraints.
analysis
highlights
potential
innovations
improve
treatment
methods
patient
Language: Английский
New Three Dimensional-Printed Polyethylene Terephthalate Glycol Liners for Hip Joint Endoprostheses: A Bioactive Platform for Bone Regeneration
Gheorghe Iosub,
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Ioana-Alexandra Lungescu,
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Alexandra Cătălina Bîrcă
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et al.
Materials,
Journal Year:
2025,
Volume and Issue:
18(6), P. 1206 - 1206
Published: March 8, 2025
Osteoporosis
and
bone
defects
are
commonly
observed
in
postmenopausal
women,
often
linked
to
decreased
folic
acid
levels,
which
play
a
crucial
role
metabolism
regeneration.
This
study
investigates
3D-printed
polyethylene
terephthalate
glycol
(PETG)-based
porous
scaffolds
impregnated
with
chitosan
(CS),
hydroxyapatite
(HAp),
(FA)
for
tissue
engineering
applications.
The
PETG-CS
scaffold
serves
as
the
primary
structural
framework,
HAp
incorporated
enhance
bioactivity
through
its
osteoconductive
osteoinductive
properties.
FA
was
included
address
potential
deficiencies
quality
stimulate
cellular
differentiation.
were
fabricated
using
precise
3D
printing
techniques,
yielding
structures
controlled
porosity.
Physicochemical
analyses
confirmed
successful
integration
of
into
matrix.
Biological
evaluations
preosteoblast
cell
lines
demonstrated
enhanced
viability,
proliferation,
biocompatibility
scaffolds.
These
findings
highlight
promising
applications
PETG-CS-HAp-FA
engineering,
providing
platform
future
investigations
personalized
regenerative
therapies.
Language: Английский
Comparison of Wound Healing Effects of Different Micro-Patterned Hydrogels on the Skin of Secondary Intention Rat Model
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 239 - 239
Published: March 24, 2025
Background:
The
skin
acts
as
a
barrier
against
external
threats,
and
moisture
is
crucial
for
effective
wound
healing,
it
promotes
epithelial
cell
migration.
Thus,
high
water
content
supports
healing
by
maintaining
moisture,
absorbing
exudate,
forming
protective
barrier.
Here,
we
created
three
different
micro-patterned
hydrogels
tested
them
on
rat
wounds.
Materials
Methods:
Three
(waves,
lines,
checks)
hydrogel
patches
were
using
three-dimensional
polymer
networks.
On
SD
skin,
wounds
making
incisions,
the
applied.
rats
divided
into
experimental
groups
based
micro-patterns.
Rats
without
(vehicle)
those
with
flat
(no
shape)
considered
controls.
closure
rate
(WCR)
was
calculated,
expression
of
Col1A
protein
measured
western
blot.
Results:
After
7
days,
WCR
significantly
higher
in
treated
compared
to
vehicle
no-shape
groups.
Specifically,
highest
checks
group
waves
lines
Furthermore,
evaluated
at
days
14,
revealing
significant
increase
after
14
Conclusions:
demonstrated
superior
efficacy,
indicated
increased
days.
These
findings
highlight
importance
pattern
design
improving
suggesting
that
optimized
micro-patterns
can
enhance
therapeutic
outcomes
management.
Language: Английский
Formulation and Characterization of Teicoplanin Niosomal Gel for Healing Chronic Wounds Infected with Methicillin-Resistant Staphylococcus Aureus (MRSA)
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 230 - 230
Published: March 22, 2025
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
is
recognized
as
a
significant
pathogen
playing
crucial
role
in
causing
bacterial
infections
of
skin
and
soft
tissues
due
to
its
high
capacity
for
biofilm
formation.
Niosome-based
gel
systems
offer
potential
enhancing
transdermal
drug
delivery
increasing
the
effectiveness
loaded
drugs.
The
current
research
investigates
feasibility
niosomal
formulating
topical
administration
teicoplanin
(TEC).
thin
film
hydration
method
was
used
niosome
formulation
composed
nonionic
surfactant,
cholesterol,
mPEG
2000.
TEC
prepared
with
adding
hydroxypropyl
methylcellulose
(HPMC)
Poloxamer
407
polymers
system.
physiochemical
characteristics
formulation,
such
particle
morphology,
size,
zeta
surface
charge,
homogeneity,
encapsulation
efficiency,
vitro
release,
were
evaluated.
Also,
antibacterial
system
analyzed.
Further,
we
examined
vivo
activity
synthesized
on
infected
wounds
Wister
rats.
We
found
that
had
anti-biofilm
capabilities
against
MRSA
isolates,
could
be
an
effective
wound
material
preventing
therapeutic
problems
related
this
superbug.
Language: Английский
Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation
Polymers,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1077 - 1077
Published: April 16, 2025
This
study
investigates
the
preparation
of
electrospun
recycled
polyethylene
terephthalate
(rPET)
coated
with
chitosan
(CS)
and
evaluates
their
antibiofilm
properties
in
vivo
response.
rPET
scaffolds
were
first
fabricated
via
electrospinning
at
different
flow
rates
(10,
7.5,
5
2.5
mL/h)
subsequently
chitosan.
Scanning
electron
microscopy
(SEM)
revealed
that
fiber
morphology
varied
parameters,
influencing
microbial
adhesion.
Antimicrobial
tests
demonstrated
rPET@CS
significantly
inhibited
Staphylococcus
aureus,
Pseudomonas
aeruginosa
Candida
albicans
biofilm
formation
compared
to
control
uncoated
surfaces.
Subcutaneous
implantation
induced
a
transient
inflammatory
response,
macrophage
recruitment
collagen
deposition
supporting
tissue
integration.
These
findings
highlight
potential
as
sustainable
antimicrobial
biomaterials
for
applications
infection-resistant
coatings
biomedical
implants.
Language: Английский
Easy-to-Apply Hydrogel Patch for Field Treatment and Monitoring of Equine Wounds
Gels,
Journal Year:
2025,
Volume and Issue:
11(5), P. 328 - 328
Published: April 27, 2025
The
cicatrization
process,
which
is
critical
to
equine
health,
directly
affects
overall
well-being
by
preventing
infection,
minimizing
tissue
damage,
and
restoring
optimal
function.
Herein,
we
present
a
case
of
5-year-old
sorrel
mare
with
torn
skin
wound
on
the
dorsal
aspect
metatarsal
region
left
hind
limb,
treated
locally
an
antibiotic-free
transparent
hydrogel-based
patch
while
monitoring
its
healing
process.
induced
pink
granulation
in
area
after
42
days,
keloid
formation
was
observed
untreated
area.
Wound
measurements
showed
reduction
over
time
treatment,
complete
achieved
at
116
days.
Capillary
velvety
appearance
were
day
80.
Histological
analysis
revealed
mature
tissue,
fibrocyte
formation,
abundant
capillaries,
organized
collagen
fibrils,
development
type
III
Interestingly,
no
inflammatory
response
during
treatment.
hydrogel
not
only
accelerated
healing,
but
also
controlled
excessive
formation.
This
treatment
represents
innovative
approach
management
that
updates
applications
for
owners
reducing
costs.
Language: Английский
Zinc Alginate Hydrogel-Coated Wound Dressings: Fabrication, Characterization, and Evaluation of Anti-Infective and In Vivo Performance
Gels,
Journal Year:
2025,
Volume and Issue:
11(6), P. 427 - 427
Published: June 1, 2025
The
delayed
healing
and
infection
risks
associated
with
chronic
wounds
burns
pose
significant
clinical
challenges.
Traditional
dressings
provide
basic
coverage
but
lack
the
bioactive
properties
needed
for
tissue
regeneration
antimicrobial
protection.
In
this
study,
we
developed
zinc
alginate
hydrogel-coated
traditional
wound
(WD@AlgZn)
evaluated
their
physicochemical
properties,
performance,
in
vivo
efficacy.
Scanning
electron
microscopy
(SEM)
revealed
a
uniform
coating
of
network
on
dressing
fibers,
while
Fourier-transform
infrared
spectroscopy
(FT-IR)
confirmed
successful
incorporation
ions.
Antimicrobial
assays
further
demonstrated
that
WD@AlgZn
reduced
bacterial
loads
(CFU/mL
counts)
by
several
orders
magnitude
both
Staphylococcus
aureus
Escherichia
coli
compared
to
uncoated
controls.
An
rat
burn
model
exhibited
accelerated
closure
when
using
conventional
care
approaches,
achieving
90.75%
rate
day
21,
significantly
outperforming
silver
sulfadiazine
(52.32%),
uncoated-dressing
(46.58%),
spontaneous-healing
(37.25%)
groups.
Histological
analysis
enhanced
re-epithelialization,
neovascularization,
inflammation
WD@AlgZn-treated
tissues.
findings
suggest
offers
promising
alternative
advanced
management,
combining
structural
robustness
support
efficient
control.
These
results
valuable
insights
into
potential
applications
metal-ion
cross-linked
biopolymeric
hydrogel
next-generation
strategies.
Language: Английский