Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 133 - 133

Published: March 13, 2025

Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.

Language: Английский

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Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 271 - 271

Published: April 5, 2025

Collagen-based wound dressings have developed as an essential component of contemporary care, utilizing collagen’s inherent properties to promote healing. This review thoroughly analyzes collagen dressing advances, examining different formulations such hydrogels, films, and foams that enhance care. The important processes by which promotes healing (e.g., promoting angiogenesis, encouraging cell proliferation, offering structural support) are discussed clarify its function in tissue regeneration. effectiveness adaptability demonstrated via clinical applications investigated acute chronic wounds. Additionally, commercially accessible collagen-based skin treatments discussed, demonstrating their practical use healthcare settings. Despite the progress, study discusses obstacles restrictions encountered producing adopting dressings, difficulties manufacturing financial concerns. Finally, current landscape’s insights indicate future research possibilities for optimization, bioactive agent integration, overcoming existing constraints. analysis highlights potential innovations improve treatment methods patient

Language: Английский

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New Three Dimensional-Printed Polyethylene Terephthalate Glycol Liners for Hip Joint Endoprostheses: A Bioactive Platform for Bone Regeneration

Materials, Journal Year: 2025, Volume and Issue: 18(6), P. 1206 - 1206

Published: March 8, 2025

Osteoporosis and bone defects are commonly observed in postmenopausal women, often linked to decreased folic acid levels, which play a crucial role metabolism regeneration. This study investigates 3D-printed polyethylene terephthalate glycol (PETG)-based porous scaffolds impregnated with chitosan (CS), hydroxyapatite (HAp), (FA) for tissue engineering applications. The PETG-CS scaffold serves as the primary structural framework, HAp incorporated enhance bioactivity through its osteoconductive osteoinductive properties. FA was included address potential deficiencies quality stimulate cellular differentiation. were fabricated using precise 3D printing techniques, yielding structures controlled porosity. Physicochemical analyses confirmed successful integration of into matrix. Biological evaluations preosteoblast cell lines demonstrated enhanced viability, proliferation, biocompatibility scaffolds. These findings highlight promising applications PETG-CS-HAp-FA engineering, providing platform future investigations personalized regenerative therapies.

Language: Английский

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Comparison of Wound Healing Effects of Different Micro-Patterned Hydrogels on the Skin of Secondary Intention Rat Model

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 239 - 239

Published: March 24, 2025

Background: The skin acts as a barrier against external threats, and moisture is crucial for effective wound healing, it promotes epithelial cell migration. Thus, high water content supports healing by maintaining moisture, absorbing exudate, forming protective barrier. Here, we created three different micro-patterned hydrogels tested them on rat wounds. Materials Methods: Three (waves, lines, checks) hydrogel patches were using three-dimensional polymer networks. On SD skin, wounds making incisions, the applied. rats divided into experimental groups based micro-patterns. Rats without (vehicle) those with flat (no shape) considered controls. closure rate (WCR) was calculated, expression of Col1A protein measured western blot. Results: After 7 days, WCR significantly higher in treated compared to vehicle no-shape groups. Specifically, highest checks group waves lines Furthermore, evaluated at days 14, revealing significant increase after 14 Conclusions: demonstrated superior efficacy, indicated increased days. These findings highlight importance pattern design improving suggesting that optimized micro-patterns can enhance therapeutic outcomes management.

Language: Английский

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Formulation and Characterization of Teicoplanin Niosomal Gel for Healing Chronic Wounds Infected with Methicillin-Resistant Staphylococcus Aureus (MRSA)

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 230 - 230

Published: March 22, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a significant pathogen playing crucial role in causing bacterial infections of skin and soft tissues due to its high capacity for biofilm formation. Niosome-based gel systems offer potential enhancing transdermal drug delivery increasing the effectiveness loaded drugs. The current research investigates feasibility niosomal formulating topical administration teicoplanin (TEC). thin film hydration method was used niosome formulation composed nonionic surfactant, cholesterol, mPEG 2000. TEC prepared with adding hydroxypropyl methylcellulose (HPMC) Poloxamer 407 polymers system. physiochemical characteristics formulation, such particle morphology, size, zeta surface charge, homogeneity, encapsulation efficiency, vitro release, were evaluated. Also, antibacterial system analyzed. Further, we examined vivo activity synthesized on infected wounds Wister rats. We found that had anti-biofilm capabilities against MRSA isolates, could be an effective wound material preventing therapeutic problems related this superbug.

Language: Английский

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Electrospun Chitosan-Coated Recycled PET Scaffolds for Biomedical Applications: Short-Term Antimicrobial Efficacy and In Vivo Evaluation

Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1077 - 1077

Published: April 16, 2025

This study investigates the preparation of electrospun recycled polyethylene terephthalate (rPET) coated with chitosan (CS) and evaluates their antibiofilm properties in vivo response. rPET scaffolds were first fabricated via electrospinning at different flow rates (10, 7.5, 5 2.5 mL/h) subsequently chitosan. Scanning electron microscopy (SEM) revealed that fiber morphology varied parameters, influencing microbial adhesion. Antimicrobial tests demonstrated rPET@CS significantly inhibited Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans biofilm formation compared to control uncoated surfaces. Subcutaneous implantation induced a transient inflammatory response, macrophage recruitment collagen deposition supporting tissue integration. These findings highlight potential as sustainable antimicrobial biomaterials for applications infection-resistant coatings biomedical implants.

Language: Английский

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Easy-to-Apply Hydrogel Patch for Field Treatment and Monitoring of Equine Wounds

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 328 - 328

Published: April 27, 2025

The cicatrization process, which is critical to equine health, directly affects overall well-being by preventing infection, minimizing tissue damage, and restoring optimal function. Herein, we present a case of 5-year-old sorrel mare with torn skin wound on the dorsal aspect metatarsal region left hind limb, treated locally an antibiotic-free transparent hydrogel-based patch while monitoring its healing process. induced pink granulation in area after 42 days, keloid formation was observed untreated area. Wound measurements showed reduction over time treatment, complete achieved at 116 days. Capillary velvety appearance were day 80. Histological analysis revealed mature tissue, fibrocyte formation, abundant capillaries, organized collagen fibrils, development type III Interestingly, no inflammatory response during treatment. hydrogel not only accelerated healing, but also controlled excessive formation. This treatment represents innovative approach management that updates applications for owners reducing costs.

Language: Английский

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Zinc Alginate Hydrogel-Coated Wound Dressings: Fabrication, Characterization, and Evaluation of Anti-Infective and In Vivo Performance

Gels, Journal Year: 2025, Volume and Issue: 11(6), P. 427 - 427

Published: June 1, 2025

The delayed healing and infection risks associated with chronic wounds burns pose significant clinical challenges. Traditional dressings provide basic coverage but lack the bioactive properties needed for tissue regeneration antimicrobial protection. In this study, we developed zinc alginate hydrogel-coated traditional wound (WD@AlgZn) evaluated their physicochemical properties, performance, in vivo efficacy. Scanning electron microscopy (SEM) revealed a uniform coating of network on dressing fibers, while Fourier-transform infrared spectroscopy (FT-IR) confirmed successful incorporation ions. Antimicrobial assays further demonstrated that WD@AlgZn reduced bacterial loads (CFU/mL counts) by several orders magnitude both Staphylococcus aureus Escherichia coli compared to uncoated controls. An rat burn model exhibited accelerated closure when using conventional care approaches, achieving 90.75% rate day 21, significantly outperforming silver sulfadiazine (52.32%), uncoated-dressing (46.58%), spontaneous-healing (37.25%) groups. Histological analysis enhanced re-epithelialization, neovascularization, inflammation WD@AlgZn-treated tissues. findings suggest offers promising alternative advanced management, combining structural robustness support efficient control. These results valuable insights into potential applications metal-ion cross-linked biopolymeric hydrogel next-generation strategies.

Language: Английский

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