ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(1), P. 1207 - 1225
Published: Jan. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
This
study
provides
a
bibliometric
and
bibliographic
review
of
emerging
applications
micro-
nanotechnology
in
treating
ocular
diseases,
with
primary
focus
on
glaucoma.
We
aim
to
identify
key
research
trends
analyze
advancements
devices
drug
delivery
systems
for
treatments.
The
methodology
involved
analyzing
385
documents
indexed
the
Web
Science
using
tools
such
as
VOSviewer
Bibliometrix.
results
show
marked
increase
scientific
output,
highlighting
prominent
authors
institutions,
England
leading
field.
Key
findings
suggest
that
holds
potential
address
limitations
conventional
treatments,
including
low
bioavailability
adverse
side
effects.
Nanoparticles,
nanovesicles,
polymer-based
appear
promising
prolonged
controlled
release,
potentially
offering
enhanced
therapeutic
efficacy.
In
conclusion,
could
transform
disease
treatment,
although
challenges
remain
concerning
biocompatibility
scalability
these
devices.
Further
clinical
studies
are
necessary
establish
innovations
within
context
ophthalmology.
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 990 - 990
Published: March 14, 2025
The
use
of
agro-industrial
by-products
and
processing
residues,
which
are
rich
in
carbohydrates,
proteins,
lipids,
the
production
lipases
allows
sustainable
these
reducing
environmental
impacts.
In
this
study,
immersion
water
lentils,
soybeans,
textured
soy
protein
was
evaluated
as
carbon
nitrogen
sources
whole-cell
lipases,
resulting
biomass
used
hydrolysis
residual
soybean
oil
with
conventional
heating
ultrasound.
results
showed
that
best
culture
medium
one
50%
protein,
reaching
values
149.04
U/g
hydrolytic
activity,
12.92
g/L
concentration,
144.17
U
total
specific
volumetric
productivities
2.07
U/g·h
20.02
U/L·h,
respectively.
positive
effect
adding
frying
to
crop
observed,
increased
cell
activity.
obtained
potential
for
ultrasound-assisted
vegetable
oils,
approximately
43.36%
7
h
reaction,
an
initial
rate
31.03
mmol/h.
It
is
concluded
a
viable
candidate
replace
traditional
sources,
being
economically
attractive
alternative
due
its
wide
generation
restaurants.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Microfabrication
technology
has
advanced
scientific
understanding
and
expanded
our
molecular
control
capabilities,
enabling
the
development
of
3D
models
in
micrometer
structures.
The
sizes
fluidic
channels
are
arranged
descending
order,
starting
with
macro-,
followed
by
meso-,
micro-,
nanoscale.
These
advances
bring
advantages
speed
up
biological
chemical
experimental
processes.
Such
miniaturized
systems
show
significant
advances,
particularly
meso-
microreactors,
through
high-throughput
screening.
This
work
proposes
a
bibliometric
analysis
applications
Web
Science
(WoS)
database,
analyzing
main
highlights
publications,
indicators,
impact
on
knowledge
production.
In
past
20
years,
approximately
3,934
documents
published
cited,
mainly
major
world
powers
micro-
mesofluidic
systems,
increasingly
expanding
academic
industrial
sectors.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 29, 2025
Microbial
lipases
could
be
used
to
hydrolyze
or
recombine
fats
and
oils,
had
great
applications
in
food
processing,
bioenergy
chemical
industry.
Mucor
circinelloides
was
an
important
gamma-linolenic
acid
producing
strain,
its
genome
predicted
contain
a
large
number
of
genes
encoding
lipases,
the
key
enzymes
lipid
metabolism.
In
present
study,
potential
lipase
WJ_23
from
WJ11
cloned
for
first
time
heterologously
expressed
purified
homogeneity
Pichia
pastoris.
By
SDS-PAGE
analysis,
molecular
weight
recombinant
estimated
~
34
kDa.
The
optimal
temperature
pH
were
50
°C
9.0,
respectively.
good
thermal
stability
at
with
broad
6.0
11.0.
After
incubation
37
24
h,
activity
remained
over
95%
between
7.0
9.0.
possessed
preference
long
chain
substrates.
Using
p-NPP
as
substrate,
measured
kinetic
parameters
Vmax
Km
94.34
U/mg
6.37
mmoL/L,
addition,
not
affected
obviously
by
various
metal
ions,
it
exhibited
certain
tolerance
towards
several
kinds
organic
solvents.
This
research
might
provide
basis
further
industrial
application
M.
lipase.
ChemBioEng Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Abstract
Enzyme
immobilization
has
propelled
the
pharmaceutical
sector
forward
by
playing
a
critical
role
in
chemical
synthesis;
therefore,
biocatalyst
reuse
industries
received
significant
attention
due
to
its
eco‐friendly
nature
and
potential
for
streamlining
future
utilization.
In
particular,
nitrilases
have
emerged
as
biocatalysts
synthesizing
intermediates
active
ingredients
(APIs).
created
platform
nitrilase
that
significantly
improved
thermal
stability
reusability,
increasing
commercial
value
industry.
The
current
article
provides
comprehensive
analysis
of
recent
advances
continuous
flow
systems,
focusing
on
how
this
approach
contributes
efficiency
sustainability
exploitation
advantages
immobilization,
such
stability,
ease
isolation,
along
with
biocatalysts,
proven
be
an
invaluable
tool
pursuit
more
environment‐friendly
efficient
synthesis.
