Leveraging Optical Anisotropy of the Morpho Butterfly Wing for Quantitative, Stain‐Free, and Contact‐Free Assessment of Biological Tissue Microstructures

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Changes in the density and organization of fibrous biological tissues often accompany progression serious diseases ranging from fibrosis to neurodegenerative diseases, heart disease cancer. However, challenges cost, complexity, or precision faced by existing imaging methodologies materials pose barriers elucidating role tissue microstructure disease. Here, we leverage intrinsic optical anisotropy Morpho butterfly wing introduce Morpho-Enhanced Polarized Light Microscopy (MorE-PoL), a stain- contact-free platform that enhances quantifies birefringent material properties tissues. We develop mathematical model, based on Jones calculus, which describes organization. As representative example, analyzed collagen-dense collagen-sparse human breast cancer sections our technique assess microstructural distinct regions interest. compare results with conventional Hematoxylin Eosin (H&E) staining procedures second harmonic generation (SHG) microscopy for fibrillar collagen detection. Our findings demonstrate MorE-PoL provides robust, quantitative, accessible route toward analyzing microstructures, great potential application broad range materials.

Language: Английский

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Ultrafast Photonic PCR with All‐Solution‐Processed Ti₃C₂T_x‐Based Perfect Absorbers

Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Polymerase chain reaction (PCR) is a critical tool for nucleic acid amplification in molecular diagnosis and genetic analysis. Point‐of‐care (POC) devices are essential controlling the spread of infectious diseases, but developing cost‐effective chip‐based PCR systems remains challenge. This study introduces photonic chip featuring perfect metamaterial absorber made Ti 3 C 2 T x MXene, silicon dioxide (SiO ), gold nanoparticles (GNP) metal‐insulator‐metal (MIM) configuration. Fabricated via solution‐processing approach, demonstrates 98% light absorption without need expensive lithographic methods. Utilizing 940 nm infrared (IR) LED, achieves efficient photothermal effects with heating rates ≈8.3 °C s⁻¹ cooling ≈7.2 during 30 cycles λ‐DNA SARS‐CoV‐2 amplification, transitioning from 65 to 95 °C. The low cost high efficiency MXene‐based absorbers highlight their potential as key components ultrafast, energy‐efficient diagnostic chips suitable on‐site applications.

Language: Английский

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Ultrahigh-Q Quasi-BICs via Precision-Controlled Asymmetry in Dielectric Metasurfaces

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Achieving ultrahigh quality factor optical resonances is crucial for advancing low-threshold lasers, high-sensitivity sensors, and nonlinear photonics. While dielectric metasurfaces supporting quasi-bound states in the continuum (qBICs) show great potential, their experimental realization has been challenging due to difficulty of precisely controlling symmetry-breaking at nanoscale. Here, we introduce a precision-controlled symmetry-protected qBIC method using angular perturbations tune asymmetry, ensuring both high precision reproducibility Q-factors. In contrast traditional SP-qBIC excitation, which relies on uncontrolled our offers more accurate consistent control by tuning instead structural variations. Additionally, approach defines lower limit achievable Q-factors, providing reliable bound. The demonstration SP-qBICs composite nanoslit achieves record-breaking Q-factor 1.1 × 105-the highest reported date. These findings offer promising platform designing ultrahigh-Q resonators next-generation photonic-applications.

Language: Английский

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Nanofabrication for Nanophotonics

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Nanofabrication, a pivotal technology at the intersection of nanoscale engineering and high-resolution patterning, has substantially advanced over recent decades. This enables creation nanopatterns on substrates crucial for developing nanophotonic devices other applications in diverse fields including electronics biosciences. Here, this mega-review comprehensively explores various facets nanofabrication focusing its application nanophotonics. It delves into techniques like focused ion beam electron lithography, methods 3D complex structure fabrication, scalable manufacturing approaches, material compatibility considerations. Special attention is given to emerging trends such as utilization two-photon lithography structures materials phase change substances 2D with excitonic properties. By highlighting these advancements, review aims provide insights ongoing evolution nanofabrication, encouraging further research creating functional nanostructures. work encapsulates critical developments future perspectives, offering detailed narrative state-of-the-art tailored both new researchers seasoned experts field.

Language: Английский

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Inverse design of nanophotonic devices enabled by optimization algorithms and deep learning: recent achievements and future prospects

Nanophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Nanophotonics, which explores significant light–matter interactions at the nanoscale, has facilitated advancements across numerous research fields. A key objective in this area is design of ultra-compact, high-performance nanophotonic devices to pave way for next-generation photonics. While conventional brute-force, intuition-based forward methods have produced successful solutions over past several decades, recent developments optimization and artificial intelligence offer new potential expand these capabilities. In review, we delve into latest progress inverse devices, where AI are leveraged automate enhance process. We discuss representative commonly employed design, including various meta-heuristic algorithms such as trajectory-based, evolutionary, swarm-based approaches, addition adjoint-based optimization. Furthermore, explore state-of-the-art deep learning techniques, involving discriminative models, generative reinforcement learning. also introduce categorize notable inverse-designed their respective methodologies. Additionally, summarize open-source tools commercial foundries. Finally, provide our perspectives on current challenges while offering insights future directions that could further advance rapidly evolving field.

Language: Английский

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Thermostable terahertz metasurface enabled by graphene assembly film for plasmon-induced transparency

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 29, 2025

Language: Английский

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Ultra-narrowband dielectric metasurfaces for surface-enhanced infrared absorption

Applied Physics Letters, Journal Year: 2025, Volume and Issue: 126(9)

Published: March 1, 2025

Quasi-bound states in the continuum (QBICs) mid-infrared region have been widely explored to enhance light–matter interactions for biochemical sensing. However, their steep dispersion bands often limit Q-factor stability under focused light. Here, we design and experimentally demonstrate a super QBIC within flatband by introducing lateral geometric perturbations square lattice of etched holes high-index Ge films, enabling strong coupling between energy bands. The achieves theoretical two orders magnitude higher than conventional QBICs, with nearly zero group velocity, supports ultra-narrowband resonances slow light effect. Experimentally, report robust ∼270 at tilted angle, full width half maximum ∼22 nm, field enhancement ∼23 accessible optical cavities. Vibrational is achieved mode C=O vibrational polymethylmethacrylate molecules, Rabi splitting 24.2 cm−1 detuning. Differential transmission spectra reveal fivefold molecular absorption due localization. These results potential metasurfaces advancing surface-enhanced infrared micrometer scale.

Language: Английский

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Recent advances in dynamic single-molecule analysis platforms for diagnostics: advantages over bulk assays and miniaturization approaches

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 278, P. 117361 - 117361

Published: March 10, 2025

Language: Английский

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Intelligent nanophotonics: when machine learning sheds light

eLight, Journal Year: 2025, Volume and Issue: 5(1)

Published: April 11, 2025

Language: Английский

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Synergy between AI and Optical Metasurfaces: A Critical Overview of Recent Advances

Photonics, Journal Year: 2024, Volume and Issue: 11(5), P. 442 - 442

Published: May 9, 2024

The interplay between two paradigms, artificial intelligence (AI) and optical metasurfaces, nowadays appears obvious unavoidable. AI is permeating literally all facets of human activity, from science arts to everyday life. On the other hand, metasurfaces offer diverse sophisticated multifunctionalities, many which appeared impossible only a short time ago. use for optimization general approach that has become ubiquitous. However, here we are witnessing two-way process—AI improving but some also AI. helps design, analyze utilize while ensure creation all-optical chips. This ensures positive feedback where each enhances one: this may well be revolution in making. A vast number publications already cover either first or second direction; modest includes both. an attempt make reader-friendly critical overview emerging synergy. It succinctly reviews research trends, stressing most recent findings. Then, it considers possible future developments challenges. author hopes broad interdisciplinary will useful both dedicated experts scholarly audience.

Language: Английский

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