Langmuir,
Journal Year:
2025,
Volume and Issue:
41(5), P. 3583 - 3591
Published: Jan. 30, 2025
Since
the
outbreak
of
novel
coronavirus
(SARS-CoV-2),
world
has
suffered
significant
losses.
At
present,
pneumonia
disease
caused
by
SARS-CoV-2
virus
not
been
eliminated,
and
a
high
mutation
rate,
its
variant
strains
also
have
prevalence
which
always
threatened
health
all
mankind.
This
study
aims
to
develop
rapid
sensitive
method
complement
existing
diagnostic
tools
utilizing
surface-enhanced
Raman
spectroscopy
(SERS)
for
direct
detection
intrinsic
SERS
signal
from
S
proteins
variants
(Omicron
Delta)
within
5
min
using
portable
spectrometer.
The
linear
range
protein
Wild-type,
Omicron
Delta
ranged
1.0
×
10-7
10-3
g·mL-1,
limits
(LOD)
were
down
∼10-8
g·mL-1
level.
Our
proposed
uses
spectrometer
detection,
is
characterized
simplicity,
rapidity,
portability,
wide
applicability.
It
enables
simultaneous
diverse
mutated
targets,
thereby
playing
pivotal
role
in
early
diagnosis
viral
diseases.
Moreover,
it
holds
promising
prospects
fields
chemistry,
biology,
medicine.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(10), P. 5118 - 5148
Published: Jan. 1, 2024
3D
cancer
models
recapitulate
the
tumor
microenvironment
and
serve
as
a
platform
to
study
cell
behavior,
drug
discovery
early
diagnosis,
which
can
be
monitored
chemically
with
subcellular
resolution
in
real
time,
via
SERS.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(50)
Published: Sept. 30, 2022
Nucleic
acids
are
remarkable
molecules.
In
addition
to
Watson-Crick
base
pairing,
the
different
structural
motifs
of
these
molecules
can
bind
non-nucleic
acid
targets
or
catalyze
chemical
reactions.
Additionally,
nucleic
easily
modified
with
functional
groups.
These
properties
make
acids,
particularly
DNA,
ideally
suited
for
use
in
electrochemical
biosensors,
both
as
biorecognition
elements
and
redox
reporter
probes.
this
Minireview,
we
will
review
historical
evolution
probes
biosensors.
We
then
specific
examples
nucleic-acid-based
biosensors
that
have
been
evaluated
clinical
areas
infectious
disease,
cancer,
cardiovascular
health.
Lab on a Chip,
Journal Year:
2023,
Volume and Issue:
23(13), P. 2899 - 2921
Published: Jan. 1, 2023
This
tutorial
review
has
comprehensively
discussed
the
design
of
microfluidic
device
to
integrate
SERS
with
it,
and
addressed
key
features
challenges
integrated
platform
in
study
cancer-derived
small
extracellular
vesicles
(sEVs).
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
An
entropy-driven
catalysis
(EDC)
strategy
is
appealing
for
amplified
bioimaging
of
microRNAs
in
living
cells;
yet,
complex
operation
procedures,
lacking
cell
selectivity,
and
insufficient
accuracy
hamper
its
further
applications.
Here,
we
introduce
an
ingenious
all-in-one
DNA
nanomachine
(termed
as
AIO-EDN),
which
can
be
triggered
by
endogenous
apurinic/apyrimidinic
endonuclease
1
(APE1)
to
achieve
tumor
cell-selective
dual-mode
imaging
microRNA.
Compared
with
the
traditional
EDC
strategy,
integrated
design
AIO-EDN
achieves
autocatalytic
signal
amplification
without
extra
fuel
strands.
Moreover,
leverages
APE1
overexpressed
cancer
cells
activate
reaction,
which,
however,
exerts
no
target
sensing
activity
normal
cells.
Combining
fluorescence-
surface-enhanced
Raman
scattering
(FL/SERS)
techniques,
this
exhibits
significantly
improved
selectivity
microRNA
This
study
provides
a
new
paradigm
develop
EDC-based
platform
shows
great
potential
in-depth
diagnosis
high
precision.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(45), P. 51468 - 51475
Published: Nov. 2, 2022
Benefiting
from
the
electromagnetic
enhancement
of
noble
metal
nanoparticles
(NPs)
and
capture
ability
organic
frameworks,
plasmonic
metal-organic
framework
(MOF)
structures
have
greatly
promoted
development
gas
detection
by
surface-enhanced
Raman
spectroscopy
(SERS).
In
those
detections,
kinetic
process
gaseous
molecules
in
plasmonic-MOF
has
a
great
influence
on
SERS
spectra,
which
is
still
lacking
intensive
investigation
previous
reports.
this
work,
processes
thiophenol
compounds
(TPC)
Zeolitic
Imidazolate
Framework
(Ag@ZIF)
core-shell
NPs
are
studied
spectra.
The
experimental
data
demonstrate
that
intensities
TPC
could
be
enhanced
once
more
an
H2
mixed
environment
with
different
functional
groups
TPC.
Further
results
reveal
two-step
not
only
related
to
thicknesses
MOF
shell
but
also
affected
ambient
gas.
To
understand
novel
phenomenon,
binding
energy
between
molecule
ZIF
calculated
based
first-principles
computation.
combination
properties
Ag
core,
molecular
collision
model
introduced
here
show
distribution
ZIF,
responsible
for
interesting
intensities.
Furthermore,
assisted
p-aminothiophenol
(PATP)
analyzed
classical
pseudo-first-order
model,
consistent
our
data.
Our
work
reveals
phenomenon
improve
spectra
enriches
understanding
microcosmic
optimize
storage.
Chemosensors,
Journal Year:
2023,
Volume and Issue:
11(2), P. 110 - 110
Published: Feb. 3, 2023
Precision
cancer
medicine
necessitates
a
personalized
treatment
plan
for
each
individual
patient.
Given
cancer’s
heterogeneity
and
dynamic
nature,
the
plot
of
patient-specific
signatures
composed
multiple
circulating
biomarkers
is
useful
to
reveal
complete
tumor
landscape
guiding
precision
medicine.
As
an
emerging
new
technology,
surface-enhanced
Raman
scattering
(SERS)
shows
intrinsic
advantage
performing
multiplexed
detection
with
extremely
narrow
spectral
line
widths.
In
this
review,
we
first
discuss
design
principle
SERS
nanotags
enable
biomarkers,
highlighting
important
roles
plasmonic
nanostructures
triple
bond-modulated
reporters.
Following
this,
detail
use
isotropic
anisotropic
as
enhancement
substrates
amplifying
signals
in
multi-biomarker
detection.
Furthermore,
present
molecules
reporters
expand
multiplexing
capability
biomarker
measurements.
Finally,
offer
critical
insights
into
challenges
perspectives
diagnosis,
particularly
from
aspect
future
clinical
transition.
It
expected
that
review
can
facilitate
more
functional
high
sensitivity
assist
early
accurate
screening.
We
also
believe
our
will
be
interest
fields
molecular
imaging,
biomedicine,
analytical
chemistry.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(8), P. 10450 - 10458
Published: Feb. 15, 2024
Surface-enhanced
Raman
spectroscopy
has
emerged
as
a
powerful
technique
for
detection
with
its
capacity
label-free,
nondestructive
analysis,
and
ultrasensitive
characterization.
High-performance
surface-enhanced
scattering
(SERS)
substrates
homogeneity
low
cost
are
the
key
factors
in
chemical
biomedical
analysis.
In
this
study,
we
propose
of
atomic
force
microscopy
(AFM)
scratching
nanoskiving
to
prepare
periodic
folded
gold
(Au)
nanostructures
SERS
substrates.
Initially,
Au
tunable
nanogaps
structures
created
through
films
by
AFM,
deposition
Ag/Au
films,
cutting
epoxy
resin,
reducing
fabrication
operational
complexity.
Periodic
show
three-dimensional
nanofocusing
effect,
hotspot
standing
wave
effect
generate
an
extremely
high
electromagnetic
field.
As
typical
molecule
be
tested,
p-aminothiophenol
lowest
limit
up
10-9
M,
owing
balance
between
field
energy
concentration
transmission
loss
nanostructures.
Finally,
precisely
controlling
periods
nanogap
widths
nanostructures,
synergistic
surface
plasmon
resonance
is
optimized
shows
good
properties,
providing
new
strategy
preparation
plasmonic
