Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 16, 2025
Abstract
The
rapidly
advancing
field
of
theranostics
aims
to
integrate
therapeutic
and
diagnostic
functionalities
into
a
single
platform
for
precision
medicine,
enabling
the
simultaneous
treatment
monitoring
diseases.
Photo‐energy
conversion‐based
nanomaterials
have
emerged
as
versatile
that
utilizes
unique
properties
light
activate
with
high
spatial
temporal
precision.
This
review
provides
comprehensive
overview
recent
developments
in
photo‐energy
conversion
using
nanomaterials,
highlighting
their
applications
disease
theranostics.
discussion
begins
by
exploring
fundamental
principles
including
types
materials
used
various
light‐triggered
mechanisms,
such
photoluminescence,
photothermal,
photoelectric,
photoacoustic,
photo‐triggered
SERS,
photodynamic
processes.
Following
this,
delves
broad
spectrum
emphasizing
role
diagnosis
major
diseases,
cancer,
neurodegenerative
disorders,
retinal
degeneration,
osteoarthritis.
Finally,
challenges
opportunities
technologies
are
discussed,
aiming
advance
personalized
medicine.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: May 6, 2023
Abstract
Surface-Enhanced
Raman
Scattering
(SERS)
technology,
as
a
powerful
tool
to
identify
molecular
species
by
collecting
spectral
signals
at
the
single-molecule
level,
has
achieved
substantial
progresses
in
fields
of
environmental
science,
medical
diagnosis,
food
safety,
and
biological
analysis.
As
deepening
research
is
delved
into
SERS
sensing,
more
high-performance
or
multifunctional
substrate
materials
emerge,
which
are
expected
push
sensing
application
fields.
Especially
field
analysis,
intrinsic
extrinsic
schemes
have
been
widely
used
explored
due
their
fast,
sensitive
reliable
advantages.
Herein,
recent
developments
substrates
applications
biomolecular
detection
(SARS-CoV-2
virus,
tumor
etc.),
imaging
pesticide
summarized.
The
concepts
(including
its
basic
theory
mechanism)
important
strategies
(extending
from
nanomaterials
with
tunable
shapes
nanostructures
surface
bio-functionalization
modifying
affinity
groups
specific
biomolecules)
for
improving
biosensing
performance
comprehensively
discussed.
For
data
analysis
identification,
machine
learning
methods
software
acquisition
sources
diagnosing
discussed
detail.
In
conclusion,
challenges
perspectives
future
presented.
Nano Convergence,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Aug. 17, 2024
Surface-enhanced
Raman
scattering
(SERS)
remains
a
significant
area
of
research
since
it's
discovery
50
years
ago.
The
surface-based
technique
has
been
used
in
wide
variety
fields,
most
prominently
chemical
detection,
cellular
imaging
and
medical
diagnostics,
offering
high
sensitivity
specificity
when
probing
quantifying
chosen
analyte
or
monitoring
nanoparticle
uptake
accumulation.
However,
despite
its
promise,
SERS
is
mostly
confined
to
academic
laboratories
not
recognised
as
gold
standard
analytical
technique.
This
due
the
variations
that
are
observed
measurements,
mainly
caused
by
poorly
characterised
substrates,
lack
universal
calibration
methods
uncorrelated
results.
To
convince
wider
scientific
community
should
be
routinely
technique,
field
now
focusing
on
will
increase
reproducibility
signals
how
validate
results
with
more
well-established
techniques.
review
explores
difficulties
experienced
users,
adopted
reduce
variation
suggestions
best
practices
strategies
if
one
achieve
absolute
quantification.
Chemical Engineering Journal,
Journal Year:
2023,
Volume and Issue:
470, P. 144023 - 144023
Published: June 8, 2023
Pesticide
residues
in
food
products
cause
human
health
concerns
through
contamination,
thereby
necessitating
their
rapid
and
facile
detection.
Although
surface-enhanced
Raman
scattering
(SERS)
technique
can
rapidly
reliably
detect
pesticide
residues,
its
application
safety
diagnostics
is
restricted
by
high
expense,
low
scalability,
reproducibility
of
the
necessary
sensors.
Herein,
we
present
a
low-cost,
large-scale,
highly
reproducible
nanofabrication
route
for
SERS
nano-sensors,
based
on
thermophoresis-assisted
direct
deposition
plasmonic
core–shell
structured
Ag-SiO2
nanoparticles
produced
gas
phase,
temperature-controlled
inexpensive
glass
substrates.
The
high-performance
substrates
were
fabricated
at
laboratory
production
rate
100
samples/hour,
demonstrating
scalability
cost-effectiveness
our
aerosol
manufacturing
strategy.
Our
sensitive
quantitatively
detected
fresh
orange,
indicating
practical
applicability
diagnostics.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Nov. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 5, 2024
Nanotechnology
has
emerged
as
a
pivotal
tool
in
biomedical
research,
particularly
developing
advanced
sensing
platforms
for
disease
diagnosis
and
therapeutic
monitoring.
Since
gold
nanoparticles
are
biocompatible
have
special
optical
characteristics,
they
excellent
choices
surface-enhanced
Raman
scattering
(SERS)
devices.
Integrating
fluorescence
characteristics
further
enhances
their
utility
real-time
imaging
tracking
within
biological
systems.
The
synergistic
combination
of
SERS
enables
sensitive
selective
detection
biomolecules
at
trace
levels,
providing
versatile
platform
early
cancer
drug
In
detection,
AuNPs
facilitate
the
specific
targeting
biomarkers,
allowing
early-stage
personalized
treatment
strategies.
enhanced
sensitivity
SERS,
coupled
with
tunable
properties
AuNPs,
offers
powerful
identification
cells
microenvironment.
This
dual-mode
not
only
improves
diagnostic
accuracy
but
also
monitoring
response
progression.
integrating
provides
robust
identifying
quantifying
pharmaceutical
compounds.
unique
spectral
fingerprints
obtained
through
enable
discrimination
molecules
even
complex
matrices.
Furthermore,
property
makes
it
easier
to
track
medication
distribution
real-time,
maximizing
effectiveness
reducing
adverse
effects.
review
explores
role
photodynamic
therapy
(PDT).
By
using
complementary
effects
targeted
release
light-induced
cytotoxicity,
SERS-guided
delivery
(PDT)
can
increase
against
cells.
conclusion,
utilization
conjunction
holds
tremendous
potential
revolutionizing
analysis,
therapy.
capabilities
these
nanomaterials
provide
multifaceted
approach
address
challenges
diagnosis,
monitoring,
medicine,
thereby
advancing
landscape
applications.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
100, P. 106007 - 106007
Published: Aug. 5, 2024
Globally,
cancer
is
regarded
as
a
severe
health
issue.
Among
these
breast
(BC),
the
second
most
common
kind
in
women
after
skin
cancer.
According
to
statistical
data
from
NIH
Cancer
Institute,
expected
number
of
cases
was
around
3
lakh
people,
with
7.1
%
fatality
rate.
The
rise
multidrug
resistance
(MDR)
British
Columbia
issue
it
lowers
effectiveness
existing
treatments.
Traditional
MDR
treatment
approaches
BC
have
drawbacks,
including
toxicity,
high
cost,
early
discharge,
restricted
drug
load
before
target,
and
poor
effectiveness.
Preventing
has
depended
heavily
on
developing
innovative
therapy
delivery
methods
utilizing
nanomedicine
new
diagnosing
treating
BC.
This
review
discusses
its
pathophysiology
relation
tumor
kinetics.
It
focuses
latest
therapeutic
over
traditional
like
Surgery,
Chemotherapy,
Nanomedicine,
Phototherapy,
Immunotherapy,
Gene
therapy.
also
describes
diagnostic
techniques
using
MRI/PET,
Mammography,
Microwave
Sensing,
In-silico
methods,
Molecular
techniques,
AI-machine
learning-based
tools.
discussed
limitations
nanoparticles
article
aims
identify
efficient
ways
diagnose
treat
prevent
recurrence.
