Nanotechnology,
Journal Year:
2024,
Volume and Issue:
35(29), P. 295502 - 295502
Published: April 11, 2024
Abstract
Numerous
efforts
have
been
undertaken
to
mitigate
the
Debye
screening
effect
of
FET
biosensors
for
achieving
higher
sensitivity.
There
are
few
reports
that
show
sub-femtomolar
detection
biomolecules
by
mechanisms
but
they
either
suffer
from
significant
background
noise
or
lack
robust
control.
In
this
aspect,
deformed/crumpled
graphene
has
recently
deployed
other
researchers
various
biomolecule
like
DNA,
COVID-19
spike
proteins
and
immunity
markers
IL-6
at
levels.
However,
chemical
vapor
deposition
(CVD)
approach
fabrication
suffers
surface
contamination
while
transfer
process
induces
structural
defects.
paper,
an
alternative
methodology
proposed
where
glass
substrate
initially
texturized
wet
etching
through
sacrificial
layer
synthesized
silver
nanoparticles,
obtained
annealing
thin
films
leading
solid
state
dewetting.
Graphene
subsequently
deposited
thermal
reduction
technique
oxide
solution.
The
resulting
deformed
structure
exhibits
sensor
response
towards
glial
fibrillary
acidic
protein
(GFAP)
with
respect
flat
owing
combined
reduced
area
receptor
immobilization.
Additionally,
another
interesting
aspect
reported
work
lies
in
capture
dielectrophoretic
(DEP)
transport
on
crests
convex
surfaces
a
coplanar
gated
topology
which
resulted
10
aM
28
limits
GFAP
buffer
undiluted
plasma
respectively,
within
15
min
application
analyte.
limit
is
almost
four
decades
lower
than
documented
using
expected
pave
way
advancing
based
sensors
ultrasensitive
point-of-care
diagnosis
GFAP,
biomarker
traumatic
brain
injury.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(18), P. 18629 - 18640
Published: Sept. 13, 2023
The
SARS-CoV-2
pandemic
has
highlighted
the
need
for
devices
capable
of
carrying
out
rapid
differential
detection
viruses
that
may
manifest
similar
physiological
symptoms
yet
demand
tailored
treatment
plans.
Seasonal
influenza
be
exacerbated
by
COVID-19
infections,
increasing
burden
on
healthcare
systems.
In
this
work,
we
demonstrate
a
technology
based
liquid-gated
graphene
field-effect
transistors
(GFETs),
and
ultraprecise
sensing
differentiation
surface
protein.
Most
distinctively,
device
consists
4
onboard
GFETs
arranged
in
quadruple
architecture,
where
each
quarter
is
functionalized
individually
(with
either
antibodies
or
chemically
passivated
control)
but
measured
jointly.
sensor
platform
was
tested
against
range
concentrations
viral
proteins
from
both
with
lowest
detected
concentration
at
∼50
ag/mL,
88
zM
227
Flu,
which
5-fold
lower
than
values
reported
previously
platform.
Unlike
classic
real-time
polymerase
chain
reaction
test,
turnaround
time
few
hours,
presents
an
ultrafast
response
∼10
s
even
complex
clinically
relevant
media
such
as
saliva.
Thus,
have
developed
multianalyte,
highly
sensitive,
fault-tolerant
diagnostic
contemporary,
emerging,
future
pandemics.
Small Structures,
Journal Year:
2023,
Volume and Issue:
4(10)
Published: July 8, 2023
Graphene
is
a
2D
honeycomb
lattice
consisting
of
single
layer
carbon
atoms.
has
become
one
the
most
preferred
materials
for
sensor
development
due
to
its
exceptional
electrical,
mechanical,
and
thermal
characteristics.
Nonetheless,
little
consideration
given
production
use
crumpled
graphene.
Specifically,
graphene
structure
good
choice
enhancing
sensors’
sensitivity
structural
deformability
by
reducing
interfacial
stress,
avoiding
electrical
failure,
surface
areas.
This
review
article
provides
an
overview
various
synthesis
processes
using
specifies
brief
idea
control
formation
in
sensing
applications
recent
years.
Furthermore,
it
summarizes
problems
encountered
previously
published
research
articles
during
fabrication
performance
sensors
with
discussion
fundamental
mechanics
topological
aspects
concerning
crumpling
patterns
performance.
It
also
highlights
current
status
techniques
their
effects
on
developing
different
existing
methods,
controlled
designs,
methodologies
future
applications.
Nanotechnology,
Journal Year:
2024,
Volume and Issue:
35(29), P. 295502 - 295502
Published: April 11, 2024
Abstract
Numerous
efforts
have
been
undertaken
to
mitigate
the
Debye
screening
effect
of
FET
biosensors
for
achieving
higher
sensitivity.
There
are
few
reports
that
show
sub-femtomolar
detection
biomolecules
by
mechanisms
but
they
either
suffer
from
significant
background
noise
or
lack
robust
control.
In
this
aspect,
deformed/crumpled
graphene
has
recently
deployed
other
researchers
various
biomolecule
like
DNA,
COVID-19
spike
proteins
and
immunity
markers
IL-6
at
levels.
However,
chemical
vapor
deposition
(CVD)
approach
fabrication
suffers
surface
contamination
while
transfer
process
induces
structural
defects.
paper,
an
alternative
methodology
proposed
where
glass
substrate
initially
texturized
wet
etching
through
sacrificial
layer
synthesized
silver
nanoparticles,
obtained
annealing
thin
films
leading
solid
state
dewetting.
Graphene
subsequently
deposited
thermal
reduction
technique
oxide
solution.
The
resulting
deformed
structure
exhibits
sensor
response
towards
glial
fibrillary
acidic
protein
(GFAP)
with
respect
flat
owing
combined
reduced
area
receptor
immobilization.
Additionally,
another
interesting
aspect
reported
work
lies
in
capture
dielectrophoretic
(DEP)
transport
on
crests
convex
surfaces
a
coplanar
gated
topology
which
resulted
10
aM
28
limits
GFAP
buffer
undiluted
plasma
respectively,
within
15
min
application
analyte.
limit
is
almost
four
decades
lower
than
documented
using
expected
pave
way
advancing
based
sensors
ultrasensitive
point-of-care
diagnosis
GFAP,
biomarker
traumatic
brain
injury.
