Imaging Wireless Electrode Reactions by Bipolar Electrochemiluminescence DOI Creative Commons
Elena Villani

Electrochemistry, Journal Year: 2024, Volume and Issue: 92(10), P. 101007 - 101007

Published: Aug. 6, 2024

The coupling between bipolar electrochemistry and electrochemiluminescence (ECL) technologies has resulted in a fascinating field of the academic research, because advantages both techniques are often emphasized their combined form.For instance, light emission resulting from an electrochemical reaction typical ECL process can be exploited for reporting redox events occurring on wireless electrode (BPE).After introducing concept electrochemiluminescence, this comprehensive paper summarizes most recent research results author aforementioned area at Tokyo Institute Technology during her multi-year stay as overseas researcher.These include development analytical tool based imaging to map potential distribution different types cells, characterization conducting polymer materials ability promote reaction.Such findings assessed relation current literature scenario, whereas future perspectives also discussed end manuscript.

Language: Английский

Iridium Complex with Specific Intercalation in the G-Quadruplex: A Phosphorescence and Electrochemiluminescence Dual-Mode Homogeneous Biosensor for Enzyme-Free and Label-Free Detection of MicroRNA DOI
Haiyin Li, Qiaoting Yang, Zhixin Wang

et al.

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(4), P. 1529 - 1535

Published: March 24, 2023

Design and exploitation of high-property multifunctional emitters for achieving immobilization-free, label-free, enzyme-free, dual-mode determination microRNA (miRNA) with high sensitivity selectivity are particularly urgent but remain a huge challenge. Herein, the first time, we reported an Ir3+-based N-heterocyclic complex, namely, IrPyPt, ascertained its phosphorescence electrochemiluminescence (ECL) dual-emission behavior in homogeneous solution, discovered turn-up signal-off ECL response to G-quadruplex DNA over other DNAs. Inspired by this, IrPyPt was pioneered as emitter combine nucleic acid probes (ON1 ON2) developing biosensor, which applied highly sensitive, credible analysis miRNA-21 used target analyte. triggered hybridization chain reaction ON1 ON2 generate abundant G-quadruplexes, caught yield IrPyPt@G-quadruplex, intramolecular rotary motion inhibited unable diffuse electrode, contributing boosted emission sharply declined emission. With this design, achieved limits detection down 1.40 0.18 pM, respectively. Furthermore, biosensor triumphantly determine concentration cancer cell lysates thus provided great potential alternative miRNA-related diseases' early accurate diagnosis.

Language: Английский

Citations

72
Electrochemiluminescence from Single Molecule to Imaging DOI
Jinrun Dong, Jiandong Feng

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(1), P. 374 - 387

Published: Jan. 10, 2023

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTElectrochemiluminescence from Single Molecule to ImagingJinrun DongJinrun DongLaboratory of Experimental Physical Biology, Department Chemistry, Zhejiang University, Hangzhou, 310027, ChinaMore by Jinrun DongView Biography and Jiandong Feng*Jiandong FengLaboratory China*Email: [email protected]More FengView Biographyhttps://orcid.org/0000-0002-2143-3986Cite this: Anal. Chem. 2023, 95, 1, 374–387Publication Date (Web):January 10, 2023Publication History Received22 October 2022Published online10 January 2023Published inissue 10 2023https://pubs.acs.org/doi/10.1021/acs.analchem.2c04663https://doi.org/10.1021/acs.analchem.2c04663review-articleACS PublicationsCopyright © 2023 American Chemical SocietyRequest reuse permissionsArticle Views2204Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electrodes,Fluorescence imaging,Imaging,Microscopy,Molecules Get e-Alerts

Language: Английский

Citations

25
Recent advances on electrochemistry of diamond related materials DOI
Siyu Yu, Shetian Liu, Xin Jiang

et al.

Carbon, Journal Year: 2022, Volume and Issue: 200, P. 517 - 542

Published: Sept. 17, 2022

Language: Английский

Citations

37
Quantitative Single‐Molecule Electrochemiluminescence Bioassay DOI
Wenxin Zhu, Jinrun Dong, Guo-Xiang Ruan

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(7)

Published: Dec. 12, 2022

A single-molecule electrochemiluminescence bioassay is developed here which allows imaging and direct quantification of single biomolecules. Imaging biomolecules realized by localizing the events labeled molecules. Such an system mapping spatial distribution with contains quantitative insights. We further quantify spatiotemporally merging repeated reactions at one molecule site then counting clustered The proposed used to detect carcinoembryonic antigen, showing a limit detection 67 attomole concentration 10 000 times better than conventional bioassays. This resolution sensitivity enable new toolbox for both specific bioimaging ultrasensitive analysis.

Language: Английский

Citations

36
Detection of COVID-19: A Smartphone-Based Machine-Learning-Assisted ECL Immunoassay Approach with the Ability of RT-PCR CT Value Prediction DOI
Ali Firoozbakhtian, Morteza Hosseini, Mahsa Sheikholeslami

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(47), P. 16361 - 16368

Published: Nov. 16, 2022

The unstoppable spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely threatened public health over the past years. current ubiquitously accepted method for its diagnosis provides sensitive detection virus; however, it is relatively time-consuming and costly, not to mention need highly skilled personnel. There a clear develop novel computer-based diagnostic tools provide rapid, cost-efficient, time-saving in places where massive traditional testing practical. Here, we an electrochemiluminescence (ECL)-based system whose results are quantified as reverse transcriptase polymerase chain reaction (RT-PCR) cyclic threshold (CT) values. A concentration-dependent signal generated upon introduction virus electrode recorded with smartphone camera. ECL images used train machine learning algorithms, model using artificial neural networks (ANNs) 45 samples was developed. demonstrated more than 90% accuracy 50 unknown real samples, detecting up CT value 32 limit (LOD) 10–12 g mL–1 samples.

Language: Английский

Citations

35
Recent development of electrochemical and optical aptasensors for detection of antibiotics in food monitoring applications DOI
Muhammad Ihda H.L. Zein, Ari Hardianto,

Irkham Irkham

et al.

Journal of Food Composition and Analysis, Journal Year: 2023, Volume and Issue: 124, P. 105644 - 105644

Published: Sept. 1, 2023

Language: Английский

Citations

18
Unravelling microstructure-electroactivity relationships in free-standing polycrystalline boron-doped diamond: A mapping study DOI Creative Commons
Zhichao Liu, Simona Baluchová, Ziyu Li

et al.

Acta Materialia, Journal Year: 2024, Volume and Issue: 266, P. 119671 - 119671

Published: Jan. 12, 2024

In this work, four different techniques were concurrently applied to study the interplay between local electroactivity and electrode surface characteristics of free-standing, polycrystalline boron-doped diamond (BDD). Scanning electron microscopy, back-scatter diffraction, Raman mapping scanning electrochemical microscopy used probe morphology, grain orientation boundaries, composition, activity, respectively. Both nucleation growth BDD surfaces together with cross-section area carefully investigated for first time in a single using combination all techniques. This enabled us obtain significant insights into highly heterogeneous nature material. Notably, boron dopants confirmed be non-uniformly distributed over material, which is characterized by distinct columnar structure composition grains various orientations. Particularly, highest activity was recorded on doped (111) crystal orientation. contrast, averagely (100)-oriented facet showed non-conductive nature. highlights that strongly grain-dependent most factors governing obtained responses are crystallographic doping. Moreover, increased sp2 carbon content boundary regions recognized mapping. However, such localized enrichment impurities did not translate enhanced implies atoms at inter-grain areas predominantly inactive. Finally, it crucial consider including orientation, particularly relevant if micro- nanoscale probing intended.

Language: Английский

Citations

7
From theory to practice: understanding the challenges in the implementation of electrogenerated chemiluminescence for analytical applications DOI Creative Commons

Gabriele Giagu,

Alessandro Fracassa, Andrea Fiorani

et al.

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(6)

Published: May 31, 2024

Electrogenerated chemiluminescence (ECL) stands out as a remarkable phenomenon of light emission at electrodes initiated by electrogenerated species in solution. Characterized its exceptional sensitivity and minimal background optical signals, ECL finds applications across diverse domains, including biosensing, imaging, various analytical applications. This review aims to serve comprehensive guide the utilization Beginning with brief exposition on theory basis generation, we elucidate systems employed initiate ECL. Furthermore, delineate principal utilized for generation contexts, elucidating both advantages challenges inherent their use. Additionally, provide an overview different electrode materials novel ECL-based protocols tailored purposes, specific emphasis biosensing

Language: Английский

Citations

7
Enhancing electrochemiluminescence intensity through emission layer control DOI Creative Commons
Chiara Mariani, Sara Bogialli, Francesco Paolucci

et al.

Electrochimica Acta, Journal Year: 2024, Volume and Issue: 489, P. 144256 - 144256

Published: April 9, 2024

Electrochemiluminescence (ECL), an intriguing luminescent phenomenon induced by electrochemical stimulation, has evolved from studying electron transfer reactions to a powerful analytical method and imaging technique. ECL can be generated through annihilation or co-reactant methods, with recent advancements integrating it into devices for diverse applications. This review traces the evolution of its early applications developments in technology. Notably, utilization charge-coupled (CCD) multiplying (EMCCD) microscopy revolutionized capabilities, making cost-effective option point-of-care testing. The explores heterogeneous mechanism, emphasizing limitations challenges visualizing objects away electrode surface. synergy between is highlighted, showcasing contributions understanding mechanisms improving use biological contexts. Finally, encapsulates innovative approaches material design, surface modification, architecture, providing comprehensive overview strategies control active layer advance microscopy.

Language: Английский

Citations

6
Recent advances in electrochemiluminescence immunosensing DOI Creative Commons
Jing Yu, Dalibor M. Stanković, Jasmina Vidić

et al.

Sensors & Diagnostics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Herein, we review the recent developments and applications of ECL for immunosensing in different areas, such as detection biomarkers, bead-based bacteria cell analysis, provide future perspectives new developments.

Language: Английский

Citations

6