Cited by Ultrasensitive 2,4,6-trinitrophenol nanofluidic sensor inspired by olfactory sensory neurons in sniffer dogs

Jun‐Ge Li,

Yi‐Lun Ying, Yi‐Tao Long

et al.

Accounts of Chemical Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ConspectusIons are the crucial signaling components for living organisms. In cells, their transportation across pore-forming membrane proteins is vital regulating physiological functions, such as generating ionic current signals in response to target molecule recognition. This ion transport affected by confined interactions and local environments within protein pore. Therefore, can efficiently transduce characteristics of each into ion-transport-mediated with high sensitivity. Inspired nature, various pores have been developed high-throughput label-free nanopore sensors single-molecule detection, enabling rapid accurate readouts. particular, aerolysin, a key virulence factor Aeromonas hydrophila, exhibits sensitivity fingerprints detecting subtle differences sequence, conformation, structure DNA, proteins, polypeptides, oligosaccharides, other molecules. Aerolysin features cap that approximately 14 nm wide on cis side central pore about 10 long minimum diameter around 1 nm. Its lumen, 11 charged rings at two entrances neutral amino acids between, facilitates dwelling single analyte characteristic enables rich between well-defined residues analyte. As result, signal offers unique molecular fingerprint, extending beyond traditional volume exclusion model sensing. 2006, aerolysin was first reported discriminate conformational peptides, opening door rapidly growing field electrochemistry. Over years, mutant nanopores emerged, associated advanced instrumentation data analysis algorithms, simultaneous identification over 30 targets number still increasing. electrochemistry particular allows time-resolved qualitative quantitative ranging from DNA sequencing, proteomics, enzyme kinetics, reactions potential clinical diagnostics. Especially, feasibility dynamic would revolutionize omics studies level, paving way promising temporal omics. Despite success this approach so far, it remains challenging understand how correlate distinguishable signatures. Recent attempts added correction terms account variations mobility caused Account, we revisit origin blockade induced molecules inside nanopore. We highlight contributions noncovalent sensing ability through corrected conductance model. Account then describes design interaction networks nanopore, including electrostatic, hydrophobic, hydrogen-bonding, cation−π, ion–charged acid interactions, ultrasensitive biomolecular quantification. Finally, provide an outlook further understanding network improving manipulating fine-tuning toward broad range practical applications.

Language: Английский

Citations

PNA-Functionalized, Silica Nanowires-Filled Glass Microtube for Ultrasensitive and Label-Free Detection of miRNA-21 DOI

Shiwei Xu,

Guofeng Wang,

Yueyue Feng

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(19), P. 7470 - 7478

Published: May 2, 2024

MicroRNAs (miRNAs) are endogenous and noncoding single-stranded RNA molecules with a length of approximately 18–25 nucleotides, which play an undeniable role in early cancer screening. Therefore, it is very important to develop ultrasensitive highly specific method for detecting miRNAs. Here, we present bottom-up assembly approach modifying glass microtubes silica nanowires (SiNWs) label-free sensing platform miRNA-21 detection. The three-dimensional (3D) networks formed by SiNWs make them abundant accessible sites binding peptide nucleic acid (PNA). As receptor, PNA has no phosphate groups exhibits overall electrically neutral state, resulting relatively small repulsion between RNA, can improve the hybridization efficiency. SiNWs-filled microtube (SiNWs@GMT) sensor enables ultrasensitive, detection limit as low 1 aM at range aM–100 nM. Noteworthy, still detect 102–108 fM complex solutions containing 1000-fold homologous interference high anti-interference performance specifically recognize target presence other miRNAs distinguish 1-, 3-mismatch nucleotide sequences. Significantly, able lysate breast cell lines (e.g., MCF-7 cells MDA-MB-231 cells), indicating that good potential screening cancers.

Language: Английский

Citations

Iontronic Sensing Based on Confined Ion Transport DOI

Saud Asif Ahmed, Ying Liu, Tianyi Xiong

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8056 - 8077

Published: April 25, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTIontronic Sensing Based on Confined Ion TransportSaud Asif AhmedSaud AhmedBeijing National Laboratory for Molecular Science, CAS Key of Analytical Chemistry Living Biosystems, Institute Chemistry, Chinese Academy Sciences, Beijing 100190, ChinaMore by Saud AhmedView BiographyView Biography, Ying LiuYing LiuBeijing ChinaUniversity Liu, Tianyi XiongTianyi XiongBeijing Xiong, Yueru ZhaoYueru ZhaoBeijing Zhao, Boyang XieBoyang XieBeijing Xie, Cong PanCong PanBeijing Pan, Wenjie MaWenjie MaBeijing Ma, and Ping Yu*Ping YuBeijing China*[email protected]More Yuhttps://orcid.org/0000-0002-6096-1933Cite this: Anal. Chem. 2024, 96, 20, 8056–8077Publication Date (Web):April 25, 2024Publication History Received12 March 2024Accepted15 April 2024Revised12 2024Published online25 inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.4c01354https://doi.org/10.1021/acs.analchem.4c01354review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views638Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Charge transport,Ions,Nanoparticles,Nanopores,Sensors Get e-Alerts

Language: Английский

Citations

Olfactory-Inspired Separation-Sensing Nanochannel-Based Electronics for Wireless Sweat Monitoring DOI

Yuge Wu,

Qi Wang, Xin Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Human sweat has the potential to be sufficiently utilized for noninvasive monitoring. Given complexity of secretion, sensitivity and selectivity monitoring should further improved. Here, we developed an olfactory-inspired separation-sensing nanochannel-based electronic sensitive selective monitoring, which was simultaneously endowed with interferent separation target detection performances. The special strategy imparts functional composite membranes a high 113 mV dec–1 potassium detection. excellent mechanical properties conformability Kevlar aramid nanofiber layer bring well-wearing performances realize continuous wireless recognition between molecules ions is proved at molecular level in detail article. replacement proves universality performance enhancement intricate biofluid analysis systems.

Language: Английский

Citations

Microfluidic synthesis of highly disordered lanthanum tellurate for the selective electrochemical detection of imidacloprid DOI

Natarajan Karikalan,

Annamalai Yamuna,

Tae Yoon Lee

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160265 - 160265

Published: Feb. 1, 2025

Language: Английский

Citations

Improving compound identification results by automatically recognizing in-source fragment ions in HRMS with AntDAS: a study on accurate pesticide screening in complex food samples DOI

Hui Ma,

Meng Zhai,

Lihua Tang

et al.

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1746, P. 465806 - 465806

Published: Feb. 20, 2025

Language: Английский

Citations

Dual signal output detection of acetamiprid residues in medicine and food homology products via nanopore biosensor DOI

Yao Li,

Jiyuan Tu, Hong Wang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144030 - 144030

Published: March 1, 2025

Language: Английский

Citations

A Portable Electrochemical Biosensor Based on an Amino-Modified Ionic Metal–Organic Framework for the One-Site Detection of Multiple Organophosphorus Pesticides DOI

Qi Wu, Yifei Wang, Linxia Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Constructing stable, portable sensors and revealing their mechanisms is challenging. Ion metal-organic frameworks (IMOFs) are poised to serve as highly effective electrochemical for detecting organophosphorus pesticides (OPs), leveraging unique charge properties. In this work, an amino-modified IMOF was constructed combined with near-field communication (NFC) technology develop a portable, touchless, battery-free biosensor

Language: Английский

Citations

Asymmetric Nanopore Sensor for Logic Detection of Dam and M.SssI Methyltransferases in Combination of DNA Walker and Autocatalytic Hybridization Reaction DOI

Siqi Zhang,

Huahao Shao,

Wei Shi

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(41), P. 16415 - 16424

Published: Oct. 3, 2024

The detection of DNA methyltransferase (MTase) was crucial for understanding gene expression regulation, cancer mechanisms, and various biological processes, contributing significantly to disease diagnosis drug development. Herein, a nanopore sensor based on cascaded signal amplification walker autocatalytic hybridization reaction (AHR) developed the ultrasensitive determination MTases. In presence Dam MTase, hairpin structure H

Language: Английский

Citations

Bioinspired solid-state nanochannel for molecules analysis DOI

Xin Li, Congcong Zhu,

Yuge Wu

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

The acute sensory behaviour in living organisms relies on the highly efficient transport of ions biological nanochannels, which has inspired design and applications artificial solid-state nanochannels field sensitive analysis. application for analysis is now widely investigated, a variety sensors have been developed. By coupling reliable nanochannel fabrication techniques with multitude surface modification strategies, novel customized sensing capabilities are generated by integration recognition elements nanochannels. altered physicochemical properties these will be manifested steady-state currents when they affected target analyte. In this mini-review, we focus emerging based different processes such as electron-beam etching, anodic oxidation, ion track self-assembly. Also, modifications discussed, including nucleic acids, proteins, small molecules, responsive materials. key factors during detection also reviewed, charge, channel size, wettability. bioinspired exploration molecules (gas drug molecules) concisely presented. Furthermore, discuss future developments challenges.

Language: Английский

Citations