Talanta, Journal Year: 2024, Volume and Issue: 286, P. 127475 - 127475
Published: Dec. 26, 2024
Language: Английский
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 206 - 206
Published: March 15, 2025
Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.
Language: Английский
Citations
1
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Although "hotspots" have been utilized to enhance Raman signals for detecting various biomolecules, precisely regulating "hotspot" dimensions within enhancement substrates remains a significant challenge. This study introduces novel, easily fabricated surface-enhanced spectroscopy sensor, T6(OH⁻)/Ag@CC. platform employs single-stranded DNA of adjustable lengths mediate the self-assembly silver nanoparticles (Ag NPs), resulting in uniformly enhanced substrate with spatially organized metal-organic frameworks architecture. The DNA-mediated exhibits pH-responsive characteristics, enabling precise control over distribution. Comprehensive characterization and experiments demonstrate that optimal signal amplification are achieved under alkaline conditions. sensor demonstrates excellent reproducibility sensitivity, label-free detection folic acid limit as low 0.1 ng mL-1. Validation using real-world food biological samples highlights its ability accurately detect identify fingerprints spinach, chicken liver, human fluids, including breast milk, serum, erythrocytes, urine. analysis characteristic peak intensities underscores potential this method versatile unified approach across diverse sample matrices.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Since the 1980s, surface enhanced Raman scattering (SERS) has been used for rapid and sensitive detection of biomolecules. Whether a label-free or labeled assay is adopted, SERS demonstrated low limits in variety biological matrices. However, analysis confined to laboratory due several reasons such as reproducibility scalability, both which have discussed at length literature. Another possible issue with lack widespread adoption that its application point use (POU) testing only now being fully explored advent portable spectrometers. Researchers are investigating how can be output on POU platforms lateral flow assays, wearable sensors, volatile organic compound (VOC) human healthcare monitoring, favorable results rival gold standard approaches. obstacle faces interpretation wealth information obtained from platform. To combat this, machine learning shown provide quick accurate generated data, leading discrimination many clinically relevant This review will discuss advancements combined strength bring produce powerful platform monitoring.
Language: Английский
Citations
0
Journal of Pharmaceutical and Biomedical Analysis Open, Journal Year: 2025, Volume and Issue: unknown, P. 100074 - 100074
Published: March 1, 2025
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
With the goal of impacting patient quality life and outcomes, sensor science offers significant potential to revolutionize healthcare by providing advances in detection molecular biomarkers for personalized clinical technologies. The community has achieved technical advancements that can impact diagnostics, health monitoring, disease treatment; however, many innovations remain confined laboratory, failing bridge translational gap between research real-world applications. This perspective presents a new direction community, where development centers on needs experiences primary beneficiaries: patients. We provide guidelines resources researchers engage with patients early continuously throughout process inform specifications better align technologies needs, improving their adoption impact. also present examples implementing patient-centered approach planning engagement research. In design impactful sensors patients, must expand focus beyond embrace approach, which will likely lead opportunities collaboration evolution community.
Language: Английский
Citations
0
Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 41
Published: April 3, 2025
Language: Английский
Citations
0
Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 128225 - 128225
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 3, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156130 - 156130
Published: Sept. 1, 2024
Language: Английский
Citations
3
Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 719 - 719
Published: Nov. 7, 2024
Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent transformative advancement management of diseases through non-invasive drug delivery. These innovative devices consist micrometer-sized needles made native or crosslinked hydrophilic polymers, capable penetrating stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling form hydrogel conduit that enables efficient transport directly into microcirculation. The nature enhances patient compliance by eliminating pain and discomfort associated with traditional hypodermic needles. This allows delivery wide range drugs, including macromolecules biomacromolecules, which are often difficult administer dermally due their size polarity. Moreover, provide controlled regulated release profiles, enabling sustained effects while minimizing systemic side effects. Additionally, can be used both real-time fluid monitoring, valuable insights disease states treatment responses. dual functionality positions versatile dermatology tool effectively addressing complications. review explores use polymeric biomaterials HFMN fabrication application major disorders, such acne, psoriasis, other skin Furthermore, highlights MN-based treatments, underscoring reduce improve adherence, supported recent literature.
Language: Английский
Citations
3