Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Language: Английский

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Simplified Biochemical Analysis Using p-Block Metals and Their Compounds with Silver─Surface Enhancement from the Point of View of Electronic Structure

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

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Streamlined Flow Synthesis of Plasmonic Nanoparticles and SERS Detection of Uremic Toxins with Trace-Level Liquid Volumes in a Microchamber

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(46), P. 63268 - 63283

Published: Nov. 8, 2024

Rapid detection of uremic toxins is crucial due to their severe health risks, including oxidative stress, inflammation, neurotoxicity, cardiovascular complications, and progression chronic kidney disease. Surface-enhanced Raman spectroscopy (SERS) may provide sensitive, fast, clinical-grade real-time monitoring these toxins, enabling effective management with timely dialysis treatments. This study introduces a 3D-printed microchamber that integrates the fabrication plasmonic metal nanoparticles for in-flow biological pharmaceutical drugs using SERS, making it ideal on-site diagnostics in clinical settings. The supports quantitative highly reproducible liquid volumes under 100 μL, which trace-level biomarker minimizing cross-contamination. It employs tunable solvent exchange method situ synthesis silver (AgNPs) on flexible PDMS or rigid Si wafer substrates, avoiding costly nanofabrication techniques. Ultralow limits were achieved two model compounds three drugs: 10–11 M rhodamine 6G, 10–7 adenine, 10–6 drugs. A total 13 neurotransmitters, one neuromodulator, five amino acids, polyamines, urea cycle metabolites, detected ranging from 10–3 M, all below permissible levels aligning physiological conditions. SERS within microchambers facilitates rapid analysis, proving personalized monitoring, point-of-care diagnostics, environmental pollution assessment.

Language: Английский

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Contribution of Nobel Laureate and Physicist Sir CV Raman in Oncosurgery

Indian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

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