Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions

ChemSusChem, Journal Year: 2022, Volume and Issue: 15(17)

Published: July 21, 2022

Mechanochemical transformations have made chemists enter unknown territories, forcing a different chemistry perspective. While questioning or revisiting familiar concepts belonging to solution chemistry, mechanochemistry has broken new ground, especially in the panorama of organic synthesis. Not only does it foster "thinking outside box", but also opened reaction paths, allowing overcome weaknesses traditional exactly where use well-established solution-based methodologies rules out progress. In this Review, reader is introduced an intriguing research subject not yet fully explored and waiting for improved understanding. Indeed, study mainly focused on that, although impossible solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation expanding chemical space.

Language: Английский

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Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(11), P. 4243 - 4260

Published: Jan. 1, 2022

Reactive extrusion provides a scale-up opportunity to turn mechanochemical process from ball-mill into continuous flow. This tutorial review summarises some of the early ground-breaking work in this area.

Language: Английский

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Green metrics in mechanochemistry

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(19), P. 6680 - 6714

Published: Jan. 1, 2023

The quantitative assessment of the greenness mechanochemical processes for green metrics were calculated is herein reported. A general introduction to topic, variables influencing reaction outcome and, an outlook are also provided.

Language: Английский

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Tinkering with Mechanochemical Tools for Scale Up

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(44)

Published: April 28, 2023

Mechanochemistry provides an environmentally benign platform to develop more sustainable chemical processes by limiting raw materials, energy use, and waste generation while using physically smaller equipment. A continuously growing research community has steadily showcased examples of beneficial mechanochemistry applications at both the laboratory preparative scale. In contrast solution-based chemistry, mechanochemical have not yet been standardized, thus scaling up is still a nascent discipline. The purpose this Minireview highlight similarities, differences challenges various approaches that successfully applied for range scales. We hope provide discussion starting point those interested in further developing commercial use and/or industrialisation.

Language: Английский

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Mechanochemical Transformations of Biomass into Functional Materials

ChemSusChem, Journal Year: 2022, Volume and Issue: 15(7)

Published: Feb. 9, 2022

Abstract Biomass is one of the promising alternatives to petroleum‐derived materials and plays a major role in our fight against climate change by providing renewable sources chemicals materials. Owing its chemical structural complexity, transformation biomass into value‐added products requires profound understanding composition at different scales innovative methods such as combining physical processes. In this context, use mechanochemistry valorization currently growing owing potentials an efficient, sustainable, environmentally friendly approach. This review highlights latest advances (i. e., chitin, cellulose, hemicellulose, lignin, starch) functional using mechanochemical‐assisted methods. We focused here on methodology processing, influencing factors, resulting properties with emphasis achieving rather than breaking down biopolymer chains smaller molecules. Opportunities limitations associated were discussed accordingly for future directions.

Language: Английский

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Life cycle assessment and techno-economic analysis of nitrogen recovery by ammonia air-stripping from wastewater treatment

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159499 - 159499

Published: Oct. 17, 2022

Language: Английский

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Methods for Monitoring Milling Reactions and Mechanistic Studies of Mechanochemistry: A Primer

Crystal Growth & Design, Journal Year: 2022, Volume and Issue: 22(9), P. 5726 - 5754

Published: Aug. 21, 2022

Mechanochemistry by ball milling is garnering significant attention as an efficient and versatile means of chemical synthesis which minimizes the need for solvents reduces amount energy required to conduct many molecular transformations. Understanding reactions often requires monitoring reaction solid forms, with little or ideally no disruption process. Herein, we provide a broad but succinct summary how different ex situ more recently developed in techniques have been applied monitor mechanochemical reactions, revealing pathways mechanisms driving solid-state materials transformations milling. The rapidly evolving field has already revolutionized our understanding complex self-assembled phases intermediates catalytic other types through multitude reported investigating are touched upon this summary, promise dramatically increase pace development chemistry.

Language: Английский

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Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing

Organic Process Research & Development, Journal Year: 2023, Volume and Issue: 27(3), P. 409 - 422

Published: Feb. 13, 2023

Recently, pharmaceutical cocrystals have gained immense interest because of their potential to tune mechanical, pharmacokinetic, and physicochemical properties active ingredients (APIs) while keeping therapeutic action intact. In this review, cocrystallization is raised as a viable strategy toward commercialized manufacturing, where attention has been paid solid-state cocrystal preparation methods opportunities challenges in overall product process development. A comparative study the form mechanical energy demonstrated with aid SELECT criteria qualitatively evaluate synthetic route selection scalable mechanochemical methods. Remedies alternatives for that arise synthesis are presented highlighting commercial perspectives sustainable, eco-friendly, less toxic

Language: Английский

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Mechanochemical-assisted decarboxylative sulfonylation of α,β-unsaturated carboxylic acids with sodium sulfinate salts

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(5), P. 2721 - 2729

Published: Jan. 1, 2024

Herein, we report a mechanochemical-assisted decarboxylative sulfonylation of α,β-unsaturated carboxylic acids with sodium sulfinate salts using potassium iodide as an activator under water-assisted grinding conditions.

Language: Английский

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Assessing the Greenness of Mechanochemical Processes with the DOZN 2.0 Tool

ACS Sustainable Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 10(16), P. 5110 - 5116

Published: March 10, 2022

As the demand increases for more sustainable chemical production, mechanochemical processes have been proposed as greener alternatives to traditional manufacturing methods. To support transition processes, quantitative assessment methods must be developed measure and compare greenness of processes. MilliporeSigma's DOZN 2.0 Green Chemistry Evaluator was utilized quantify adherence 12 Principles synthesis Active Pharmaceutical Ingredient (API) nitrofurantoin in batch continuous Through this analysis, SPEX mill twin-screw extrusion (TSE) were shown compared a commercial solution-based process. This conclusion result scores which demonstrated TSE having increased energy efficiency, improved resources use, reduced human environmental hazards other

Language: Английский

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