Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(5), P. 2684 - 2691
Published: Jan. 1, 2024
Herein,
we
demonstrate
a
solvent-free
mechanochemical
approach
involving
one-pot-double-step
procedure
mediated
by
solid
sodium
hypochlorite
(NaOCl·5H
2
O)
for
the
synthesis
of
sulfonamides.
ChemSusChem,
Journal Year:
2022,
Volume and Issue:
15(17)
Published: July 21, 2022
Mechanochemical
transformations
have
made
chemists
enter
unknown
territories,
forcing
a
different
chemistry
perspective.
While
questioning
or
revisiting
familiar
concepts
belonging
to
solution
chemistry,
mechanochemistry
has
broken
new
ground,
especially
in
the
panorama
of
organic
synthesis.
Not
only
does
it
foster
"thinking
outside
box",
but
also
opened
reaction
paths,
allowing
overcome
weaknesses
traditional
exactly
where
use
well-established
solution-based
methodologies
rules
out
progress.
In
this
Review,
reader
is
introduced
an
intriguing
research
subject
not
yet
fully
explored
and
waiting
for
improved
understanding.
Indeed,
study
mainly
focused
on
that,
although
impossible
solution,
become
possible
under
mechanochemical
processing
conditions,
simultaneously
entailing
innovation
expanding
chemical
space.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(11), P. 4243 - 4260
Published: Jan. 1, 2022
Reactive
extrusion
provides
a
scale-up
opportunity
to
turn
mechanochemical
process
from
ball-mill
into
continuous
flow.
This
tutorial
review
summarises
some
of
the
early
ground-breaking
work
in
this
area.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(19), P. 6680 - 6714
Published: Jan. 1, 2023
The
quantitative
assessment
of
the
greenness
mechanochemical
processes
for
green
metrics
were
calculated
is
herein
reported.
A
general
introduction
to
topic,
variables
influencing
reaction
outcome
and,
an
outlook
are
also
provided.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(44)
Published: April 28, 2023
Mechanochemistry
provides
an
environmentally
benign
platform
to
develop
more
sustainable
chemical
processes
by
limiting
raw
materials,
energy
use,
and
waste
generation
while
using
physically
smaller
equipment.
A
continuously
growing
research
community
has
steadily
showcased
examples
of
beneficial
mechanochemistry
applications
at
both
the
laboratory
preparative
scale.
In
contrast
solution-based
chemistry,
mechanochemical
have
not
yet
been
standardized,
thus
scaling
up
is
still
a
nascent
discipline.
The
purpose
this
Minireview
highlight
similarities,
differences
challenges
various
approaches
that
successfully
applied
for
range
scales.
We
hope
provide
discussion
starting
point
those
interested
in
further
developing
commercial
use
and/or
industrialisation.
ChemSusChem,
Journal Year:
2022,
Volume and Issue:
15(7)
Published: Feb. 9, 2022
Abstract
Biomass
is
one
of
the
promising
alternatives
to
petroleum‐derived
materials
and
plays
a
major
role
in
our
fight
against
climate
change
by
providing
renewable
sources
chemicals
materials.
Owing
its
chemical
structural
complexity,
transformation
biomass
into
value‐added
products
requires
profound
understanding
composition
at
different
scales
innovative
methods
such
as
combining
physical
processes.
In
this
context,
use
mechanochemistry
valorization
currently
growing
owing
potentials
an
efficient,
sustainable,
environmentally
friendly
approach.
This
review
highlights
latest
advances
(i.
e.,
chitin,
cellulose,
hemicellulose,
lignin,
starch)
functional
using
mechanochemical‐assisted
methods.
We
focused
here
on
methodology
processing,
influencing
factors,
resulting
properties
with
emphasis
achieving
rather
than
breaking
down
biopolymer
chains
smaller
molecules.
Opportunities
limitations
associated
were
discussed
accordingly
for
future
directions.
Crystal Growth & Design,
Journal Year:
2022,
Volume and Issue:
22(9), P. 5726 - 5754
Published: Aug. 21, 2022
Mechanochemistry
by
ball
milling
is
garnering
significant
attention
as
an
efficient
and
versatile
means
of
chemical
synthesis
which
minimizes
the
need
for
solvents
reduces
amount
energy
required
to
conduct
many
molecular
transformations.
Understanding
reactions
often
requires
monitoring
reaction
solid
forms,
with
little
or
ideally
no
disruption
process.
Herein,
we
provide
a
broad
but
succinct
summary
how
different
ex
situ
more
recently
developed
in
techniques
have
been
applied
monitor
mechanochemical
reactions,
revealing
pathways
mechanisms
driving
solid-state
materials
transformations
milling.
The
rapidly
evolving
field
has
already
revolutionized
our
understanding
complex
self-assembled
phases
intermediates
catalytic
other
types
through
multitude
reported
investigating
are
touched
upon
this
summary,
promise
dramatically
increase
pace
development
chemistry.
Organic Process Research & Development,
Journal Year:
2023,
Volume and Issue:
27(3), P. 409 - 422
Published: Feb. 13, 2023
Recently,
pharmaceutical
cocrystals
have
gained
immense
interest
because
of
their
potential
to
tune
mechanical,
pharmacokinetic,
and
physicochemical
properties
active
ingredients
(APIs)
while
keeping
therapeutic
action
intact.
In
this
review,
cocrystallization
is
raised
as
a
viable
strategy
toward
commercialized
manufacturing,
where
attention
has
been
paid
solid-state
cocrystal
preparation
methods
opportunities
challenges
in
overall
product
process
development.
A
comparative
study
the
form
mechanical
energy
demonstrated
with
aid
SELECT
criteria
qualitatively
evaluate
synthetic
route
selection
scalable
mechanochemical
methods.
Remedies
alternatives
for
that
arise
synthesis
are
presented
highlighting
commercial
perspectives
sustainable,
eco-friendly,
less
toxic
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(5), P. 2721 - 2729
Published: Jan. 1, 2024
Herein,
we
report
a
mechanochemical-assisted
decarboxylative
sulfonylation
of
α,β-unsaturated
carboxylic
acids
with
sodium
sulfinate
salts
using
potassium
iodide
as
an
activator
under
water-assisted
grinding
conditions.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2022,
Volume and Issue:
10(16), P. 5110 - 5116
Published: March 10, 2022
As
the
demand
increases
for
more
sustainable
chemical
production,
mechanochemical
processes
have
been
proposed
as
greener
alternatives
to
traditional
manufacturing
methods.
To
support
transition
processes,
quantitative
assessment
methods
must
be
developed
measure
and
compare
greenness
of
processes.
MilliporeSigma's
DOZN
2.0
Green
Chemistry
Evaluator
was
utilized
quantify
adherence
12
Principles
synthesis
Active
Pharmaceutical
Ingredient
(API)
nitrofurantoin
in
batch
continuous
Through
this
analysis,
SPEX
mill
twin-screw
extrusion
(TSE)
were
shown
compared
a
commercial
solution-based
process.
This
conclusion
result
scores
which
demonstrated
TSE
having
increased
energy
efficiency,
improved
resources
use,
reduced
human
environmental
hazards
other