Cytotoxicity Evaluation of Microbial Sophorolipids and Glucolipids using Normal Human Dermal Fibroblasts (NHDF) in vitro DOI Creative Commons

Sergio Oliveira Formoso,

Vincent Chaleix, Niki Baccile

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 14, P. 101862 - 101862

Published: Dec. 11, 2024

Fibroblasts are considered a key player in the wound healing process. Although this cellular family is constituted by several distinct subtypes, dermal fibroblasts crucial thanks to their ability secrete pro-regenerative growth factors, extracellular matrix (ECM) proteins and immune anti-inflammatory role. Sophorolipids (SL), sophorosides (SS) glucolipids (G), mono-unsaturated (C18:1) or saturated (C18:0), glycolipids derived from microbial fermentation of wild type engineered yeast Starmerella bombicola, constitute novel sustainable class bio-based chemicals with interesting physicochemical characteristics, which allow them form soft diverse structures hydrogels vesicles, micelles complex coacervates potential interest skin regeneration applications. In study, we first tested cytocompatibility broad set molecules on normal human (NHDF). Our results show that, up an upper threshold (0.1 % w/v), (SL-C18:1, G-C18:1, SSbola-C18:1, SL-C18:0 G-C18:0) under study were able sustain cell growth. Furthermore, selected least cytotoxic SL-C18:0) promote measuring gene expression markers (i.e. collagen, elastin, transforming factor β, fibroblast …) using qPCR. Unfortunately, none these modulated involved tissue repair. However, aims encourage community test for high-end biomedical Biosurfactants prepared natural amphiphiles growing importance, goal replacing synthetic surfactants commercial formulations. cytotoxicity profile still poorly known, especially new like single-glucose lipids bolaform sophorolipids. This wants contribute all those applications, could be developed biosurfactants contact (cosmetics, healing). We five structurally-related (C18:1 C18:0 sophorolipids, C18:1 lipids, di-sophoroside) against (NHDF) evaluate metabolic activity toxic among them. To best our knowledge, molecules, general, was never NHDF.

Language: Английский

Interpenetrated Biosurfactant–Biopolymer Orthogonal Hydrogels: The Biosurfactant’s Phase Controls the Hydrogel’s Mechanics DOI

Chloé Seyrig,

Alexandre Poirier, Javier Pérez

et al.

Biomacromolecules, Journal Year: 2022, Volume and Issue: 24(1), P. 33 - 42

Published: Dec. 28, 2022

Controlling the viscoelastic properties of hydrogels is a challenge for many applications. Low molecular weight gelators (LMWGs) like bile salts and glycolipids biopolymers chitosan alginate are good candidates developing fully biobased hybrid that combine advantages both components. Biopolymers lead to enhanced mechanics, while LMWGs add functionality. In this work, composed (gelatin, chitosan, alginate) microbial glycolipid bioamphiphiles, known as biosurfactants. Besides their biocompatibility natural origin, bioamphiphiles can present chameleonic behavior, pH ions control phase diagram in water around neutrality under strongly diluted conditions (<5 wt%). The used work behaves surfactant (micellar phase) at high or phospholipid (vesicle low pH. Moreover, neutral-to-alkaline presence calcium, it gelator (fiber phase). impact each these phases on elastic explored by means oscillatory rheology, structure studied small angle X-ray scattering. micellar vesicular reduce hydrogels, fiber has opposite effect; enhances hydrogel's strength forming an interpenetrated biopolymer–LMWG network.

Language: Английский

Citations

9
Heavy metal removal from water using the metallogelation properties of a new glycolipid biosurfactant DOI
Alexandre Poirier, Korin Ozkaya,

Julie Gredziak

et al.

Journal of Surfactants and Detergents, Journal Year: 2022, Volume and Issue: 26(2), P. 175 - 184

Published: Nov. 8, 2022

Abstract Water pollution by heavy metals is a problem in both western and developing countries. Heavy metal can be associated with human activity, such as wastewaters from processing of ore mining, but also to simple contamination metal‐rich soils. Whichever the case, chemical physical methods are generally employed depollute water. Since most chemicals themselves polluting agents, there an increasing interest finding biobased biodegradable alternative chemicals, efficient removing benign environment. Biosurfactants green produced fermentation yeasts bacteria good environmental score. Among many applications, this class compounds has been used remove contaminated Within framework, we propose new mechanism depolluting water using glucolipid biosurfactant, G‐C18:1, composed glucose (G) C18:1 fatty acid (oleic acid). This compound able form metallogel complexing cations water, thus trapping (Cu 2+ , Ni Cr Co ) gel phase. allows up 95% for cobalt 88 ± 10%, 80 3%, 59 6% Cu respectively. A dedicated structural study shows that possible because positively charged species induce gelation G‐C18:1 through micelle‐to‐wormlike phase transition, likely driven charge neutralization process. work wise control nanoscale properties strongly benefit develop sustainable future.

Language: Английский

Citations

8
In Situ Stimulation of Self-Assembly Tunes the Elastic Properties of Interpenetrated Biosurfactant–Biopolymer Hydrogels DOI

Chloé Seyrig,

Alexandre Poirier, Thomas Bizien

et al.

Biomacromolecules, Journal Year: 2022, Volume and Issue: 24(1), P. 19 - 32

Published: Dec. 27, 2022

Hydrogels are widespread soft materials, which can be used in a wide range of applications. The control over the viscoelastic properties gel is paramount importance. Ongoing environmental issues have raised consumer's concern toward use more sustainable including hydrogels. However, greener materials compatible with high functionality? In safe-by-design approach, this work demonstrates that functional hydrogels situ responsivity their elastic by external stimuli developed from entirely "sustainable" components, biobased amphiphile and biopolymers (gelatin, chitosan, alginate). bioamphiphile stimuli-responsive glycolipid obtained microbial fermentation, self-assemble into fibers, but also micelles or vesicles, water under dilution rapid variation stimuli. bioamphiphile-/biopolymer-interpenetrated modulated selectively triggering phase transition and/or biopolymer inside mean temperature pH.

Language: Английский

Citations

8
The underlying order: Isomerism as a blueprint to control the behavior of sugar-based (bio)surfactants DOI Creative Commons
Adrian Sanchez-Fernandez, Jia‐Fei Poon

Current Opinion in Colloid & Interface Science, Journal Year: 2023, Volume and Issue: 69, P. 101768 - 101768

Published: Nov. 19, 2023

Surfactants are ubiquitous in formulated products and technologies. As one of the most important commodity chemicals, their remarkable consumption leads to necessity finding sustainable alternatives. Although use renewable sources limits available chemical space for a "Green" production, great variety naturally occurring precursors, i.a., fatty acids sugars, opens myriad possibilities create biosurfactants capable replacing fatigued fossil-derived amphiphiles. Here, we visit concept isomer-directed assembly applied sugar-based surfactants, wherein amphiphile function fine-tuned through changes stereochemical regiochemical configuration molecule. such, show how isomerism define directional interactions solvation, ultimately dictating surfactants. However, general framework understand structure-function relationship these is still missing, which key realizing this divergent set tools design new

Language: Английский

Citations

4
An Encyclopedic Compendium on Chemosensing Supramolecular Metal‐organic gels DOI
Arun Sharma, Navneet Kaur, Narinder Singh

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(12)

Published: April 17, 2024

Abstract Chemosensing, an interdisciplinary scientific domain, plays a pivotal role ranging from environmental monitoring to healthcare diagnostics and (inter)national security. Metal‐organic gels (MOGs) are recognized for their stability, selectivity, responsiveness, making them valuable chemosensing applications. Researchers have explored the development of MOGs based on different metal ions ligands, allowing tailored properties sensitivities, even demonstrated applications as portable sensors such paper‐based test strips practical use. Herein, several studies related in field via UV‐visible or luminance along with electrochemical approach presented. These papers versatile materials use sensing bio analytes. This review provides foundational understanding key concepts, methodologies, recent advancements this field, fostering community.

Language: Английский

Citations

1
Efficient preparation and isolation of sophorolipids with excellent pH-regulated water solubility via environmentally friendly acid-induced chemical modifications DOI
Yang Hu,

Tianyou Cui,

Zhihong Yang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148849 - 148849

Published: Jan. 17, 2024

Language: Английский

Citations

1
Addressing the Environmental Concerns: Statistical Approach for Mg2+ and Mn2+ Mitigation in Water System Sustainability in Indonesia DOI Open Access

Mustamina Maulani

International Journal of Current Science Research and Review, Journal Year: 2024, Volume and Issue: 07(02)

Published: Feb. 26, 2024

This research aimed to determine the most effective adsorbent for reducing Mg2+ and Mn2+ levels in residential water near oil gas industry Tambun area, Bekasi, Indonesia. Bentonite was tested with varying temperature conditions. The study further compared activated charcoal bentonite as potential adsorbents, examining their efficacy under different contact times (10, 20, 30 minutes). Thus, sampling followed SNI 6989.57:2008 method surface sampling, conditioning activation initial steps. Next, adsorption experiments utilized a separating funnel, time between sample. Hence, filtrates were analyzed quantitatively using atomic absorption spectroscopy through complexometric titration.

Language: Английский

Citations

1
Harnessing Glycolipids for Supramolecular Gelation: A Contemporary Review DOI Creative Commons

Snehal Ashokrao Holey,

Rati Ranjan Nayak

ACS Omega, Journal Year: 2024, Volume and Issue: 9(24), P. 25513 - 25538

Published: June 6, 2024

Within the scope of this review, our exploration spans diverse facets amphiphilic glycolipid-based low-molecular-weight gelators (LMWGs). This journey explores glycolipid synthesis, self-assembly, and gelation with tailorable properties. It begins by examining design glycolipids their influence on gel formation. Following this, a brief several characterization techniques adds another layer to understanding these materials. The final section is dedicated unraveling various applications supramolecular gels. A meticulous analysis available correlations desired properties for distinct pivotal aspect investigation. As present moment, there exists notable absence review exclusively gelators. study aims bridge critical gap presenting an overview that provides novel insights into unique versatile applications. holistic examination seeks contribute deeper molecular design, structural characteristics, functional offering can propel advancements in converging scientific disciplines. Overall, highlights classifications glycolipid-derived particularly emphasizes capacity form

Language: Английский

Citations

1
Measuring the bending rigidity of microbial glucolipid (biosurfactant) bioamphiphile self-assembled structures by neutron spin-echo (NSE): Interdigitated vesicles, lamellae and fibers DOI Creative Commons
Niki Baccile, Vincent Chaleix, Ingo Hoffmann

et al.

Biochimica et Biophysica Acta (BBA) - Biomembranes, Journal Year: 2023, Volume and Issue: 1866(1), P. 184243 - 184243

Published: Oct. 29, 2023

Language: Английский

Citations

3
Role of Biosurfactants in Agriculture Management DOI
Asif Jamal, Muhammad Ali, Malik Badshah

et al.

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 277 - 308

Published: Jan. 1, 2023

Language: Английский

Citations

2