Dispensing Essential Oil Components through Cocrystallization: Sustainable and Smart Materials for Food Preservation and Agricultural Applications

ACS Sustainable Chemistry & Engineering, Journal Year: 2022, Volume and Issue: 10(26), P. 8388 - 8399

Published: June 24, 2022

The ever-increasing attention on environmental problems and sustainability has highlighted several related to the use of conventional pesticides in agricultural industry, e.g., toxic residues soil hazards environment human health. In search for natural antimicrobial insecticide alternatives, essential oils (EOs) their active components have emerged as promising candidates, but they suffer from some drawbacks physical properties. We exploited cocrystallization with isonicotinamide, pyrazine, 2,3,5,6-tetramethylpyrazine, 2,3-dimethylquinoxaline a workaround extend applicability carvacrol thymol pesticides, improving ambient delivery profile. cocrystals were prepared mechanochemically green solvent-free manner, purity, structure, stability investigated via powder single-crystal X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), density functional theory (DFT) calculations. Moreover, each cocrystal was also tested terms EO release by headspace–gas chromatography–mass spectrometry (GC–MS) over 14 days. report conversion new structure different stoichiometry, which seems afford delayed boost that could be very interesting food preservation applications.

Language: Английский

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Levofloxacin Cocrystal/Salt with Phthalimide and Caffeic Acid as Promising Solid-State Approach to Improve Antimicrobial Efficiency

Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 797 - 797

Published: June 13, 2022

To overcome the issue of multidrug resistant (MDR) microbes, exploration ways to improve antimicrobial efficiency existing antibiotics is one promising approaches. In search synthons with higher efficiency, in current investigations, cocrystal and amorphous salt levofloxacin hemihydrate (LEV) were developed phthalimide (PTH) caffeic acid (CFA). New materials characterized help FT-IR, Raman spectroscopy, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) thermogravimetric analysis (TGA). Shifting, attenuation, appearance/disappearance broadening bands observed FT-IR spectra as evidence required product. The PXRD pattern for LEV-PTH indicated while halo diffractogram LEV-CFA revealed nature. DSC/TG confirmed hydrated nature cocrystal/salt. dissolution rate activity against selected strains, K.pneumonia, E. coli S. typhi parent drug new material compared. zone inhibition (ZI) 5 µg was 30.4 + 0.36 (K. pneumonia), 26.33 0.35 (E. coli) 30.03 0.25 mm (S. typhi) (5 µg) same strains inhibited 33.96 ± 0.25, 31.66 27.93 0.40 mm, respectively. These novel formulations enhance well antibacterial are expected be potent MDR bacterial strains.

Language: Английский

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Crystal engineering in the development of improved pesticide products

Advanced Agrochem, Journal Year: 2022, Volume and Issue: 1(1), P. 39 - 60

Published: Sept. 1, 2022

Language: Английский

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Cocrystal engineering strategy for sustained release and leaching reduction of herbicides: a case study of metamitron

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(20), P. 8088 - 8099

Published: Jan. 1, 2022

Cocrystal engineering strategy achieved the leaching reduction and sustained release of highly water-soluble herbicides to extend their efficacy reduce groundwater contamination.

Language: Английский

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Enhancing adsorption capacity and herbicidal efficacy of 2,4-D through supramolecular self-assembly: Insights from cocrystal engineering to solution chemistry

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 469, P. 143757 - 143757

Published: June 3, 2023

Language: Английский

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A sustainable and smart fungicide release platform through cocrystal nanocapsules for improved utilization rate and environmental safety

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 473, P. 145284 - 145284

Published: Aug. 7, 2023

Language: Английский

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Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 481, P. 148407 - 148407

Published: Dec. 30, 2023

Language: Английский

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Advanced supramolecular self-assembly for lifecycle-optimized agrochemical delivery

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215953 - 215953

Published: June 1, 2024

Language: Английский

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Making Agriculture More Sustainable: An Environmentally Friendly Approach to the Synthesis of Lignin@Cu Pesticides

ACS Sustainable Chemistry & Engineering, Journal Year: 2020, Volume and Issue: 8(39), P. 14886 - 14895

Published: Sept. 8, 2020

Despite its high chemical value, most of lignin is nowadays burnt as low value fuel. It therefore important to find innovative applications for use. Copper compounds are used plant protection products more than 50 different diseases in viticulture, arable crops, hops, and horticulture, they have been 100 years. Minimization copper agriculture has become a fundamental issue due negative environmental impact. Here we present series hybrid organic–inorganic materials (lignin@Cu), deriving from the combination with brochantite, Cu4(OH)6SO4. Optimization synthetic procedures allowed us isolate lignin-based containing percentages copper, where brochantite crystals featured by morphologies dimensions. A environmentally safe synthesis lignin@Cu mechanochemistry also investigated, which reduces amount water makes easier faster isolation final materials. Tests on strawberry tomato plants greenhouse highlighted significative efficacy against pathogens at content much lower one copper-based commercial pesticides. crystal morphology–activity correlation traced out. The synergic activity ions can be reduce efficient pathogen control. Moreover, mechanochemical approach ensures greener approach, perspective sustainable agriculture.

Language: Английский

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Natural Antimicrobials Meet a Synthetic Antibiotic: Carvacrol/Thymol and Ciprofloxacin Cocrystals as a Promising Solid-State Route to Activity Enhancement

Crystal Growth & Design, Journal Year: 2020, Volume and Issue: 20(10), P. 6796 - 6803

Published: Aug. 21, 2020

The antibiotic ciprofloxacin (CIP) zwitterion has been cocrystallized via slurry and/or ball-milling with carvacrol (CAR) and thymol (THY), also known to exert antimicrobial activity, the aim of improving antibacterial activity ciprofloxacin. In case CAR, 1:4 cocrystal CIP·CAR4 appears be most stable phase, where intermediate phases CIP·CAR3 CIP·CAR2 have isolated by stepwise loss CAR. THY, 1:2 CIP·THY2 is stable, while CIP·THY4 easily loses THY yield bisadduct. All cocrystals were structurally characterized single crystal or powder diffraction: in both sheets CIP molecules are intercalated layers CAR respectively, that can released upon heating as followed DSC, TGA variable temperature XRPD. Preliminary experiments provide encouraging evidence enhanced against Escherichia coli (ATCC 25922) respect pure well physical mixtures thymol.

Language: Английский

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