Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(8), P. 4872 - 4931
Published: Jan. 1, 2021
This review comprehensively summarises stimulus-cleavable linkers from various research areas and their cleavage mechanisms, thus provides an insightful guideline to extend potential applications controlled drug release nanomaterials.
Language: Английский
Materials Science and Engineering C, Journal Year: 2017, Volume and Issue: 76, P. 1440 - 1453
Published: March 18, 2017
Language: Английский
Citations
226
Angewandte Chemie International Edition, Journal Year: 2018, Volume and Issue: 57(12), P. 3123 - 3127
Published: Jan. 31, 2018
Abstract Inflammatory cells have gained widespread attention because inflammatory diseases increase the risk for many types of cancer. Therefore, it is urgent and important to implement detection treatment methods cells. Herein, we constructed a theranostic probe with aggregation‐induced emission (AIE) characteristics, in which tetraphenylethene (TPE) was modified two tyrosine (Tyr) moieties. Owing H 2 O ‐dependent, enzyme‐catalyzed dityrosine formation, Tyr‐containing TPE ( TT ) molecules crosslink through linkages induce formation hydrophobic aggregates, activating AIE process that contain overexpress myeloperoxidase. The turn‐on resulting from crosslinking could be used distinguish between normal Moreover, massive aggregates induced mitochondria damage cell apoptosis. This study demonstrates ‐responsive peroxidase‐activated AIEgen holds great promise inflammatory‐cell selective imaging inhibition.
Language: Английский
Citations
225
Tissue Engineering Part B Reviews, Journal Year: 2020, Volume and Issue: 26(3), P. 230 - 248
Published: Jan. 13, 2020
Wound dressings are traditionally used to protect a wound and facilitate healing. Currently, their function is expanding. There an urgent need for new smart products that not only act as protective barrier but also actively support the healing process. Hydrogel example of such innovative typically by providing hospitable moist environment in which cells can thrive, while still breathe exudate be drained. These tend less painful or have soothing effect allow additional drug delivery. In this review, various strategic molecular design considerations discussed relevant developing hydrogel into dressing product. vary from material choice ease use determine dressing's final properties, application potential, benefits patient. The focus review lies on identifying explaining key aspects relevance different phases repair. Molecular targets when tailoring hydrogels toward specific scenarios. addition, potential reviewed medicine advances repair-based approach regenerative-based one. Hydrogels play role transition personal care facilitating regenerative strategies acting scaffold (stem) carrier/source bioactive molecules and/or drugs. Improved will lead better quality life around globe. It expected coincides with reduction health spending, duration treatment decreases. To achieve this, modern desired both improve comfort outcome proposed pivotal improving care, end, aims summarize made optimize purpose dressing.
Language: Английский
Citations
219
Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)
Published: Feb. 7, 2018
Colloidal gold nanoparticles (AuNPs) are of interest as non-toxic carriers for drug delivery owing to their advanced properties, such extensive surface-to-volume ratio and possibilities tailoring charge, hydrophilicity functionality through surface chemistries. To date, various biocompatible polymers have been used decoration AuNPs enhance stability, payloads capacity cellular uptake. This study describes a facile one-step method synthesize stable loaded with combination two anticancer therapeutics, -bleomycin doxorubicin. Anticancer activities, cytotoxicity, uptake intracellular localization the were demonstrated in HeLa cells. We show that therapeutic efficacy nanohybrid was strongly enhanced by active targeting nanoscale system cells significant decrease half-maximal effective concentration, blockage cancer cell cycle. These results provide rationale further progress AuNPs-assisted chemotherapy using drugs at optimized concentrations which act via different mechanisms thus decreasing development resistance, reduction systemic toxicity improvement outcomes chemotherapy.
Language: Английский
Citations
217
Matter, Journal Year: 2019, Volume and Issue: 1(2), P. 345 - 368
Published: Aug. 1, 2019
Language: Английский
Citations
217
Advances in Colloid and Interface Science, Journal Year: 2017, Volume and Issue: 242, P. 1 - 16
Published: Feb. 16, 2017
Language: Английский
Citations
213
Journal of Controlled Release, Journal Year: 2019, Volume and Issue: 319, P. 135 - 156
Published: Dec. 24, 2019
Language: Английский
Citations
209
Biomaterials Science, Journal Year: 2016, Volume and Issue: 4(3), P. 375 - 390
Published: Jan. 1, 2016
Dendrimers have shown great promise as carriers in drug delivery due to their unique structures and superior properties. However, the precise control of payload release from a dendrimer matrix still presents challenge. Stimuli-responsive dendrimers that payloads response specific trigger could offer distinct clinical advantages over those passively. These smart polymers are designed specifically at targeted regions or constant profiles for therapies. They represent an attractive alternative enable dendrimer-based therapeutics be more effective, convenient, much safer. The wide range stimuli, either endogenous (acid, enzyme, redox potentials) exogenous (light, ultrasound, temperature change), allows flexibility design stimuli-responsive dendrimers. In this review article, we will highlight recent advances opportunities development treatment various diseases, with emphasis on cancer. Specifically, applications well mechanisms intensively reviewed.
Language: Английский
Citations
198
Advanced Materials, Journal Year: 2021, Volume and Issue: 33(26)
Published: May 24, 2021
Abstract Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has shown superior performance as functional material in biomedical applications. The results multiple studies have led to the development light/hypoxia‐responsive azobenzene for use. In recent years, long‐wavelength‐responsive been developed. Matching longer wavelength absorption hypoxia‐response characteristics switch unit bio‐optical window large effective stimulus response. addition, used hypoxia‐sensitive connector via biological cleavage under appropriate conditions. This resulted on/off state switching properties such pharmacology fluorescence activity. Herein, advances design fabrication trigger biomedicine are summarized.
Language: Английский
Citations
196
ACS Nano, Journal Year: 2017, Volume and Issue: 11(12), P. 12134 - 12144
Published: Nov. 15, 2017
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration stimuli-responsive nanoparticles fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive were rationally designed to generate highly efficient agents synergistic thermo-chemotherapy. The drug-loaded polymeric selenium-inserted copolymer (I/D-Se-NPs) rapidly dissociated several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation I/D-Se-NPs such a short irradiation promoted continuous drug release. Moreover, facilitated translocation ROS-triggered lysosomal disruption thus resulted preferable distribution nucleus even 5 min postirradiation, which was further integrated with light-triggered hyperthermia achieving tumor ablation without regrowth.
Language: Английский
Citations
192