Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Bioinspired Integration of Naturally Occurring Molecules towards Universal and Smart Antibacterial Coatings

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(4)

Published: Oct. 23, 2021

Abstract Surface‐independent smart antibacterial coatings with on‐demand antibiotics release profiles have attracted increasing attention in medical instruments, delivery platforms, and implanted devices. Although several approaches been well documented, the facile preparation of onto universal substrates high loading efficiencies, tunable drug profiles, excellent performances is still met many challenges, especially related to redundant coating material synthesis selective substrate fabrication process. To resolve this issue, authors report a robust method towards surfaces on various via one‐pot integration two types naturally occurring building blocks, aminoglycosides protocatechualdehyde presence plant enzyme horseradish peroxidase. The simultaneous dynamic imine bonds formation enzymatic polymerization within system during reaction enable diverse surface‐independent coatings, which can demonstrate promising features including (i.e., pH‐responsive) properties, behaviors, efficient activities both vitro vivo. This work may offer new opportunities materials by bioinspired all natural blocks.

Language: Английский

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A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 25, 2023

Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) hypoxia-responsive prodrug multifunctional combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence photoacoustic (PA) brightness the strong light absorption ability, as well amplified type I II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating high-performance paclitaxel (PTX) into nanoparticles, further camouflaging macrophage cell membrane, tumor-targeting theranostic agent is built. integration of PA imaging helps to delineate tumor site sensitively, providing accurate guidance light-induced PDT effect could consume local oxygen lead severer hypoxia, accelerating release PTX drug. As result, chemotherapy induces immunogenic death, which not only elicit antitumor immunity suppress primary tumor, but also inhibit growth distant in 4T1 tumor-bearing female mice. strategy develop agents rational molecular design boosting

Language: Английский

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Triggered azobenzene-based prodrugs and drug delivery systems

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 475 - 493

Published: March 23, 2022

Language: Английский

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Enhancing the Release Efficiency of a Molecular Chemotherapeutic Prodrug by Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(33)

Published: June 11, 2022

Abstract Tumor‐specific, hypoxia‐activated prodrugs have been developed to alleviate the side effects of chemotherapy drugs. However, release efficiency is restricted by degree tumor hypoxia, which further leads poor cancer treatment effects. On other hand, oxygen consumed gradually in photodynamic therapy (PDT), aggravates hypoxia at site. In this study, we combined with PDT agents promote release, thereby improving their bioavailability and therapeutic As a proof concept, mitochondria‐targeted molecular prodrug, CS‐P , was designed synthesized. It can be selectively activated chemotherapeutic drugs photosensitizers, then discharge after light irradiation. The design strategy proposed paper provides new idea for enhancing prodrug real‐time monitoring release.

Language: Английский

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Stimuli-Responsive Functional Micro-/Nanorobots: A Review

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15254 - 15276

Published: Aug. 3, 2023

Stimuli-responsive functional micro-/nanorobots (srFM/Ns) are a class of intelligent, efficient, and promising microrobots that can react to external stimuli (such as temperature, light, ultrasound, pH, ion, magnetic field) perform designated tasks. Through adaptive transformation into the corresponding forms, they perfectly match demands depending on different applications, which manifest extremely important roles in targeted therapy, biological detection, tissue engineering, other fields. Promising srFM/Ns be, few reviews have focused them. It is therefore necessary provide an overview current development these intelligent clear inspiration for further this field. Hence, review summarizes advances stimuli-responsive regarding their response mechanism, achieved functions, applications highlight pros cons stimuli. Finally, we emphasize existing challenges propose possible strategies help accelerate study field promote toward actual applications.

Language: Английский

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Robust Thiazole‐Linked Covalent Organic Frameworks with Post‐Modified Azobenzene Groups: Photo‐Regulated Dye Adsorption and Separation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)

Published: March 21, 2024

Abstract Due to the intrinsic porosity and photo‐regulated pore environment, azobenzene (Azo) functionalized covalent organic frameworks (COFs) show great potential for contaminant removal. However, stability degree of functionality COFs greatly affect subsequent adsorption capacity selectivity. Herein, a highly stable thiazole‐linked COF containing phenolic hydroxyl groups (OH‐COF) is constructed by using 4,4′,4′‐(1,3,5‐triazine‐2,4,6‐triyl)trianiline 2,5‐dihydroxyterephthalaldehyde in presence sulfur, which shows high crystallinity specific surface. Azo‐functionalized ((Azo) x ‐COFs) are prepared grafting different amounts onto OH‐COF through post‐modification, whose aperture conveniently tuned grafted amount. The size ‐COFs also can be reversibly adjusted under UV visible light irradiation without affecting crystallinity. Appropriate amount Azo‐grafted 0.1 ‐COF possessed (1216.93 mg g −1 ) Congo red (CR). While 1.0 CR significantly increased 2.9 times reach 1489.96 after irradiation. selectively separate dye molecules with sizes based on size, showing excellent reversibility reusability. As such, ability photo‐regulate interception highlights their significance functioning as smart porous nanomaterials pollutant removal water purification.

Language: Английский

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Visible-Light-Activated Heteroaryl Azoswitches: Toward a More Colorful Future

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(29), P. 19609 - 19620

Published: July 11, 2024

Azobenzenes (Ph-N═N-Ph) are known as the most widely studied molecular photoswitches, and recent rise of azoheteroarenes (Het-N═N-Ph or Het-N═N-Het) offers great opportunities to advance this already mature field. A common limitation is that azo-switches generally require harmful UV light for activation, which hinders their application across various fields. Despite efforts in developing visible-light azobenzenes over past few decades, potential heteroaryl azoswitches remains largely unexplored. This Perspective summarizes state-of-the-art advancements azoswitches, covering design strategies, structure-property relationship, applications. We highlight distinctive advantages research development switches. Furthermore, we discuss challenges emerging field propose solutions address crucial issues such spectral red-shift thermal half-life. Through paper, aim provide inspiration further exploration field, anticipation growing prosperity bright future azoheteroarene photoswitches.

Language: Английский

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Light‐Responsive Materials in Droplet Manipulation for Biochemical Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 21, 2024

Miniaturized droplets, characterized by well-controlled microenvironments and capability for parallel processing, have significantly advanced the studies on enzymatic evolution, molecular diagnostics, single-cell analysis. However, manipulation of small-sized including moving, merging, trapping targeted droplets complex biochemical assays subsequent analysis, is not trivial remains technically demanding. Among various techniques, light-driven methods stand out as a promising candidate droplet in facile flexible manner, given features contactless interaction, high spatiotemporal resolution, biocompatibility. This review therefore compiles an in-depth discussion governing mechanisms underpinning manipulation. Besides, light-responsive materials, representing core light-matter interaction key character converting light into different forms energy, are particularly assessed this review. Recent advancements materials most notable applications comprehensively archived evaluated. Continuous innovations rational engineering expected to propel development manipulation, equip with enhanced functionality, broaden routine investigations.

Language: Английский

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Hypoxia‐Responsive Covalent Organic Framework Nanoplatform for Breast‐Cancer‐Targeted Cocktail Immunotherapy via Triple Therapeutic Switch Mechanisms

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia‐responsive COF designed to encapsulate the chemotherapy gambogic acid (GA) situ. Bimetallic gold‐palladium islands were grown on UiO‐66‐NH 2 (UiO) form UiO@Au‐Pd (UAPi), which encapsulated with GA through membrane formation, resulting core‐shell structure (UAPiGC). Further modification hyaluronic (HA) created @GA‐COF@HA (UAPiGCH) enhanced tumor targeting. In hypoxic microenvironment, collapses, releasing UAPi, initiating triple therapeutic response: nanozyme‐catalyzed therapy, near‐infrared II (NIR‐II) mild photothermal therapy (mild‐PTT), chemotherapy. UAPi exhibits catalase (CAT)‐like peroxidase (POD)‐like activities, generating oxygen alleviate hypoxia reactive species (ROS) destruction. acts chemotherapeutic agent inhibits heat shock protein 90 (HSP90), enhancing sensitivity. vitro vivo studies confirm UAPiGCH’s ability induce pyroptosis, stimulate dendritic cell maturation, boost T infiltration, demonstrating its potential nanoplatform. strategy integrates multiple therapies into system, offering promising applications cancer treatment.

Language: Английский

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