Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams DOI Creative Commons
Paul M. Bradley, Celeste A. Journey, Daniel T. Button

et al.

PLoS ONE, Journal Year: 2020, Volume and Issue: 15(1), P. e0228214 - e0228214

Published: Jan. 30, 2020

Human-use pharmaceuticals in urban streams link aquatic-ecosystem health to human health. Pharmaceutical mixtures have been widely reported larger due historical emphasis on wastewater-treatment plant (WWTP) sources, with limited investigation of pharmaceutical exposures and potential effects smaller headwater streams. In 2014–2017, the United States Geological Survey measured 111 compounds 308 (261 urban-gradient sites sampled 3–5 times, 47 putative low-impact once) 4 regions across US. Simultaneous multiple (pharmaceutical mixtures) were observed 91% (248 urban-gradient, 32 low-impact), 88 analytes detected all cumulative maximum concentrations up 36,142 ng/L per site. Cumulative detections correlated land use presence/absence permitted WWTP discharges, but also common 75% without WWTP. exposure-activity ratios (EAR) indicated widespread transient high probability molecular vertebrates. Considering individual interactive recognized analytical underestimation pharmaceutical-contaminant (unassessed parent compounds, metabolites, degradates) space, these results demonstrate a nation-wide environmental concern need for watershed-scale mitigation in-stream contamination.

Language: Английский

Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States DOI Creative Commons
Paul M. Bradley, Celeste A. Journey, Daniel T. Button

et al.

Environmental Science & Technology Letters, Journal Year: 2016, Volume and Issue: 3(6), P. 243 - 249

Published: May 24, 2016

Pharmaceutical contaminants are growing aquatic-health concerns and largely attributed to wastewater treatment facility (WWTF) discharges. Five biweekly water samples from 59 small Piedmont (United States) streams were analyzed for 108 pharmaceuticals degradates using high-performance liquid chromatography tandem mass spectrometry. The antidiabetic metformin was detected in 89% of at 97% sites. At least one pharmaceutical every site (median 6, maximum 45), several ≥10% sites concentrations reported affect multiple aquatic end points. Maximal cumulative (all compounds) per ranged 17 16000 ng L–1. Watershed urbanization, table depth, soil thickness, WWTF metrics correlated significantly with in-stream contamination. Comparable detections without permitted discharges demonstrate the importance non-WWTF sources need broad-scale mitigation. results highlight a fundamental biochemical link between global human-health crises like diabetes ecosystem health.

Language: Английский

Citations

99
Emerging environmental health risks associated with the land application of biosolids: a scoping review DOI Creative Commons

Elizabeth A. Pozzebon,

Lars Seifert

Environmental Health, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 21, 2023

Abstract Background Over 40% of the six million dry metric tons sewage sludge, often referred to as biosolids, produced annually in United States is land applied. Biosolids serve a sink for emerging pollutants which can be toxic and persist environment, yet their fate after application impacts on human health have not been well studied. These gaps our understanding are exacerbated by absence systematic monitoring programs defined standards protection. Methods The purpose this paper call critical attention knowledge that currently exist regarding biosolids underscore need evidence-based testing regulatory frameworks protection when A scoping review methodology was used identify research conducted within last decade, current standards, government publications applied biosolids. Results Current indicates persistent organic compounds, or pollutants, found pharmaceuticals personal care products, microplastics, per- polyfluoroalkyl substances (PFAS) potential contaminate ground surface water, uptake these from soil amended result contamination food sources. Advanced technologies remove contaminants wastewater treatment plant influent, effluent, destined along with tools detect quantify Conclusions To address risks, there needs significant investment ongoing infrastructure support advancements treatment; expanded manufacture use sustainable products; increased public communication risks associated overuse plastics; development implementation regulations protective environment.

Language: Английский

Citations

35
Cu–TiO2 nanorods with enhanced ultraviolet- and visible-light photoactivity for bisphenol A degradation DOI

Li-Fen Chiang,

Ruey‐an Doong

Journal of Hazardous Materials, Journal Year: 2014, Volume and Issue: 277, P. 84 - 92

Published: Feb. 2, 2014

Language: Английский

Citations

93
In-Stream Attenuation of Neuro-Active Pharmaceuticals and Their Metabolites DOI
Jeffrey H. Writer, Ronald C. Antweiler, Imma Ferrer

et al.

Environmental Science & Technology, Journal Year: 2013, Volume and Issue: 47(17), P. 9781 - 9790

Published: Aug. 16, 2013

In-stream attenuation was determined for 14 neuro-active pharmaceuticals and associated metabolites. Lagrangian sampling, which follows a parcel of water as it moves downstream, used to link hydrological chemical transformation processes. Wastewater loading compounds varied considerably over span several hours, thus sampling regime verify that the being sampled mechanism developed correct measured concentrations if not. 5.4-km evaluated reach could be modeled pseudo-first-order decay 11 pharmaceutical compounds, illustrating capacity streams reduce conveyance downstream. Fluoxetine N-desmethyl citalopram were most rapidly attenuated (t1/2 = 3.6 ± 0.3 h, 4.0 0.2 respectively). Lamotrigine, 10,11,-dihydro-10,11,-dihydroxy-carbamazepine, carbamazepine persistent 12 2.0 2.6 21 4.5 Parent (e.g., buproprion, carbamazepine, lamotrigine) generally more relative their Several (citalopram, venlafaxine, O-desmethyl-venlafaxine) not attenuated. It postulated primary removal these interaction with bed sediments stream biofilms, based on in biofilms column experiment using sediments.

Language: Английский

Citations

89
Mycotoxins: Diffuse and point source contributions of natural contaminants of emerging concern to streams DOI
Dana W. Kolpin,

Judith Schenzel,

Michael T. Meyer

et al.

The Science of The Total Environment, Journal Year: 2013, Volume and Issue: 470-471, P. 669 - 676

Published: Oct. 29, 2013

Language: Английский

Citations

86
An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity DOI Open Access

Adam R. Schwindt,

Dana L. Winkelman,

Kristen Keteles

et al.

Journal of Applied Ecology, Journal Year: 2014, Volume and Issue: 51(3), P. 582 - 591

Published: Feb. 20, 2014

Summary Increased need for water and projected declines in precipitation due to climate change could leave waterways increasingly dominated by wastewater effluent. Understanding how components of influence fish populations is necessary effective conservation management. Despite research demonstrating effects oestrogens, such as 17α‐ethynylestradiol ( EE 2), on physiology population failure, the generality responses uncertain underlying mechanisms affecting are unknown. 2 steroid oestrogen human contraceptive pills has been measured up 11 ng L −1 environment. We identify disrupted dynamics direct transgenerational survival fecundity. conducted a year‐long study three generations fathead minnows Pimephales promelas Rafinesque aquatic mesocosms laboratory aquaria. added environmentally relevant concentrations daily using static renewal, which approximates pulsed exposure that experience natural systems. (3·2 ) reduced F0 male 17% (48% lower than controls) juvenile production 40% compared controls. F1 continuously exposed failed reproduce, reproduction transferred clean was 70–99% less F2 larval survival, only germ cells their parents, 51–97% The indirect effect suggests possibility 2. Synthesis applications . Our results suggest 2) may not recover from exposure. Management short‐lived highly fecund fishes should be prioritized protect embryo through gonadal differentiation. Reducing effluent will possible many situations; hence, breeding rearing habitat unpolluted tributaries or reaches needed. Additionally, resource managers enhance connectivity rivers facilitate immigration. Finally, investment advanced processing technology improve removal bioactive chemicals provide baseline regulatory agencies consider when assessing ecological environmental our approach evaluating population‐level widely applied other contaminants.

Language: Английский

Citations

85
Enhanced visible-light-responsive photodegradation of bisphenol A by Cu, N-codoped titanate nanotubes prepared by microwave-assisted hydrothermal method DOI
Ruey‐an Doong,

Liao Chun-Yi

Journal of Hazardous Materials, Journal Year: 2016, Volume and Issue: 322, P. 254 - 262

Published: March 2, 2016

Language: Английский

Citations

81
Enhanced photoactivity of Cu-deposited titanate nanotubes for removal of bisphenol A DOI

Ruey-an Doong,

Sue-min Chang,

Chia-wei Tsai

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2012, Volume and Issue: 129, P. 48 - 55

Published: Sept. 16, 2012

Language: Английский

Citations

78
Whole organism responses and intersex severity in rainbow darter (Etheostoma caeruleum) following exposures to municipal wastewater in the Grand River basin, ON, Canada. Part A DOI
Paulina Bahamonde, Meghan Fuzzen,

Charles J. Bennett

et al.

Aquatic Toxicology, Journal Year: 2014, Volume and Issue: 159, P. 290 - 301

Published: Dec. 3, 2014

Language: Английский

Citations

67
Reduction of Intersex in a Wild Fish Population in Response to Major Municipal Wastewater Treatment Plant Upgrades DOI
Keegan A. Hicks, Meghan Fuzzen,

Emily K. McCann

et al.

Environmental Science & Technology, Journal Year: 2016, Volume and Issue: 51(3), P. 1811 - 1819

Published: Dec. 27, 2016

Intersex in fish downstream of municipal wastewater treatment plants (MWWTPs) is a global concern. Consistent high rates intersex male rainbow darter (Etheostoma caeruleum) have been reported for several years the Grand River, southern Ontario, Canada, close proximity to two MWWTPs. The larger MWWTP (Kitchener) recently underwent upgrades that included conversion from carbonaceous activated sludge nitrifying process. This created unique opportunity assess whether designed improve effluent quality could also remediate previously observed wild fish. Multiple (2007-2012) data on collected before at sites associated with outfall were compared postupgrade (2013-2015). These resulted reduction 70 100% incidence (preupgrade) <10% years. Although cause remains unknown, indicators including nutrients, pharmaceuticals, and estrogenicity improved after upgrades. study demonstrated investment was an immediate change biological responses receiving environment. important finding considering tremendous cost infrastructure.

Language: Английский

Citations

62