European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(32)
Published: July 25, 2022
Abstract
Halogens
play
a
crucial
part
in
synthetic
organic
chemistry.
Halo‐cyclized
products
hold
numerous
applications
the
pharmaceutical
industries,
agrochemicals,
natural
product
synthesis,
and
material
Thus,
this
review
will
discuss
role
of
various
catalysts,
such
as
from
metal‐catalysts
to
organocatalysts,
under
different
conditions
synthesize
halocyclized
products.
The
synthesis
catalytic
mechanisms
underlying
asymmetric
transformations
also
be
covered
by
emphasizing
enantioselectivities,
diastereoselectivities,
regioselectivities
existing
pieces
literature.
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
9(2), P. 499 - 516
Published: Nov. 18, 2021
Catalytic
asymmetric
halocyclization
of
olefinic
substrate
has
evolved
rapidly
and
been
well
utilized
as
a
practical
strategy
for
constructing
enantioenriched
cyclic
skeletons
in
natural
product
synthesis.
European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2021(44), P. 5946 - 5974
Published: Oct. 6, 2021
Abstract
As
a
consequence
of
the
ever‐increasing
relevance
fluorinated
drugs
in
medicinal
chemistry,
organofluorine
chemistry
has
become
hot
topic
research
area
during
last
decade.
Asymmetric
carbon‐fluorine
bond‐forming
reactions
have
enormously
developed
recent
years
with
considerable
findings
related
to
novel
and
synthetic
approaches.
These
new
efforts
contributed
access
growing
number
molecules
complex
natural
or
products
high
drug
research.
Illustrative
examples
methodologies,
including
organocatalytic
processes,
asymmetric
syntheses
phase‐transfer
catalytic
methods
for
enantioselective
incorporation
fluorine
atom(s)
into
versatile
molecular
entities,
are
covered
current
Review,
focusing
on
main
contributions
ten
years.
European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2021(29), P. 3938 - 3969
Published: June 7, 2021
Abstract
Chiral
halogenated
substances
have
many
applications
in
pharmaceuticals,
agrochemicals,
and
materials,
such
as
polymers,
liquid
crystals
intermediates
synthesis.
The
presence
of
a
halogen
atom
molecule
can
large
effect
its
properties;
for
instance,
halogens
are
used
drugs
to
improve
lipophilicity,
membrane
permeability
absorption,
even
the
blood‐brain
barrier
permeability.
As
highlighted
this
review,
there
nowadays
range
highly
selective,
versatile
halogenating
reagents,
electrophilic,
nucleophilic
or
radical
nature,
which
operate
under
mild
conditions,
allowing
late‐stage
functionalization
complex
molecules
cascade
reactions.
Recent
developments
organocatalyst
design
revealed
novel
Cinchona
alkaloids
derivatives,
chiral
phosphoric
acids,
amines,
phosphines
several
bifunctional
catalysts,
mostly
thiourea‐
squaramide‐based,
introduced
chirality,
with
high
levels
enantio‐
diastereoselection,
formation
one
multiple
centers
single
synthetic
operation,
shown.
In
review
we
survey
literature
published
field
from
2014
2020.
European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(32)
Published: July 25, 2022
Abstract
Halogens
play
a
crucial
part
in
synthetic
organic
chemistry.
Halo‐cyclized
products
hold
numerous
applications
the
pharmaceutical
industries,
agrochemicals,
natural
product
synthesis,
and
material
Thus,
this
review
will
discuss
role
of
various
catalysts,
such
as
from
metal‐catalysts
to
organocatalysts,
under
different
conditions
synthesize
halocyclized
products.
The
synthesis
catalytic
mechanisms
underlying
asymmetric
transformations
also
be
covered
by
emphasizing
enantioselectivities,
diastereoselectivities,
regioselectivities
existing
pieces
literature.
