ABC transporters are billion-year-old Maxwell Demons DOI Creative Commons
Solange Flatt, Daniel Maria Busiello, Stefano Zamuner

et al.

Communications Physics, Journal Year: 2023, Volume and Issue: 6(1)

Published: Aug. 8, 2023

Abstract ATP-Binding Cassette (ABC) transporters are a broad family of biological machines, found in most prokaryotic and eukaryotic cells, performing the crucial import or export substrates through both plasma organellar membranes, maintaining steady concentration gradient driven by ATP hydrolysis. Building upon present biophysical biochemical characterization ABC transporters, we propose here model whose solution reveals that these machines an exact molecular realization autonomous Maxwell Demon, century-old abstract device uses energy source to drive systems away from thermodynamic equilibrium. In particular, Demon does not perform any direct mechanical work on system, but simply selects which spontaneous processes allow ones forbid based information it collects processes. its version, measurement is embedded system itself. introduced here, different operations characterize Demons (measurement, feedback, resetting) features emerge structural properties revealing role allostery process information. Our framework allows us develop explicit bridge between molecular-level description higher-level language theory for transporters.

Language: Английский

Advances and opportunities in the exciting world of azobenzenes DOI
Florica Adriana Jerca, Valentin Victor Jerca, Richard Hoogenboom

et al.

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 6(1), P. 51 - 69

Published: Nov. 18, 2021

Language: Английский

Citations

296
Designing light-driven rotary molecular motors DOI Creative Commons
Daisy R. S. Pooler, Anouk S. Lubbe, Stefano Crespi

et al.

Chemical Science, Journal Year: 2021, Volume and Issue: 12(45), P. 14964 - 14986

Published: Jan. 1, 2021

Various families of light-driven rotary molecular motors and the key aspects motor design are discussed. Comparisons made between strengths weaknesses each motor. Challenges, applications, future prospects explored.

Language: Английский

Citations

151
Active mechanisorption driven by pumping cassettes DOI
Liang Feng, Yunyan Qiu, Qing‐Hui Guo

et al.

Science, Journal Year: 2021, Volume and Issue: 374(6572), P. 1215 - 1221

Published: Oct. 22, 2021

Over the past century, adsorption has been investigated extensively in equilibrium systems, with a focus on van der Waals interactions associated physisorption and electronic case of chemisorption. In this study, we demonstrate mechanisorption, which results from nonequilibrium pumping to form mechanical bonds between adsorbent adsorbate. This active mode realized surfaces metal-organic frameworks grafted arrays molecular pumps. Adsorbates are transported one well-defined compartment, bulk, another interface, thereby creating large potential gradients chemical capacitors wherein energy is stored metastable states. Mechanisorption extends, fundamental manner, scope phenomena offers transformative approach control chemistry at interfaces.

Language: Английский

Citations

134
Dissipative DNA nanotechnology DOI
Erica Del Grosso, Elisa Franco, Leonard J. Prins

et al.

Nature Chemistry, Journal Year: 2022, Volume and Issue: 14(6), P. 600 - 613

Published: June 1, 2022

Language: Английский

Citations

129
Pillararene/Calixarene-based systems for battery and supercapacitor applications DOI Creative Commons
Shuai Cao, Huacheng Zhang, Yuxin Zhao

et al.

eScience, Journal Year: 2021, Volume and Issue: 1(1), P. 28 - 43

Published: Oct. 6, 2021

Pillararene/calixarene-based functional materials have garnered significant attention for their unique topological/chemical structures and physicochemical properties, extended applications in electrochemistry given rise to a promising area of research. This review details current advance developing electrochemical energy based on pillararene/calixarene systems from the viewpoint both fundamental theoretical simulations research practical applications. First, we discuss underlying mechanisms applying pillararene/calixarene-based Second, summarize simulation studies pillarquinone calixquinone with intrinsic batteries. In addition, state-of-the-art storage devices such as lithium/sodium-ion batteries supercapacitors are highlighted. The diverse roles they play various design strategies that been investigated high-performance analyzed. Finally, prospects further developments this emerging field. not only describes recent advances but also lays firm groundwork application engineering.

Language: Английский

Citations

112
An electric molecular motor DOI Creative Commons
Long Zhang, Yunyan Qiu,

Wei-Guang Liu

et al.

Nature, Journal Year: 2023, Volume and Issue: 613(7943), P. 280 - 286

Published: Jan. 11, 2023

Macroscopic electric motors continue to have a large impact on almost every aspect of modern society. Consequently, the effort towards developing molecular

Language: Английский

Citations

90
Non-equilibrium Steady States in Catalysis, Molecular Motors, and Supramolecular Materials: Why Networks and Language Matter DOI Creative Commons
Ivan Aprahamian, Stephen M. Goldup

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(26), P. 14169 - 14183

Published: June 21, 2023

All chemists are familiar with the idea that, at equilibrium steady state, relative concentrations of species present in a system predicted by corresponding constants, which related to free energy differences between components. There is also no net flux species, matter how complicated reaction network. Achieving and harnessing non-equilibrium states, coupling network second spontaneous chemical process, has been subject work several disciplines, including operation molecular motors, assembly supramolecular materials, strategies enantioselective catalysis. We juxtapose these linked fields highlight their common features challenges as well some misconceptions that may be serving stymie progress.

Language: Английский

Citations

79
Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors DOI Creative Commons
Jorn de Jong, Jasper E. Bos, Sander J. Wezenberg

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(13), P. 8530 - 8574

Published: June 21, 2023

Anionic species are omnipresent and involved in many important biological processes. A large number of artificial anion receptors has therefore been developed. Some these capable mediating transmembrane transport. However, where transport proteins can respond to stimuli their surroundings, creation synthetic with stimuli-responsive functions poses a major challenge. Herein, we give full overview the stimulus-controlled that have developed thus far, including application membrane In addition potential operation as carriers, use recognition motifs forming responsive membrane-spanning channels is discussed. With this review article, intend increase interest among scientists working on host–guest complexes dynamic functional systems order stimulate further developments.

Language: Английский

Citations

44
Kinetic Asymmetry and Directionality of Nonequilibrium Molecular Systems DOI
R. Dean Astumian

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(9)

Published: Jan. 18, 2024

Abstract Scientists have long been fascinated by the biomolecular machines in living systems that process energy and information to sustain life. The first synthetic molecular rotor capable of performing repeated 360° rotations due a combination photo‐ thermally activated processes was reported 1999. progress designing different intervening years has remarkable, with several outstanding examples appearing last few years. Despite accomplishments, there remains confusion regarding fundamental design principles which motions molecules can be controlled, significant intellectual tension between mechanical chemical ways thinking about describing machines. A thermodynamically consistent analysis kinetics rotors pumps shows while light driven operate power‐stroke mechanism, kinetic asymmetry—the relative heights barriers—is sole determinant directionality catalysis Power‐strokes—the depths wells—play no role whatsoever determining sign directionality. These results, elaborated using trajectory thermodynamics nonequilibrium pump equality, show asymmetry governs response many non‐equilibrium phenomena.

Language: Английский

Citations

23
Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers DOI

Wen-Zhi Wang,

Li‐Bo Huang, Shao‐Ping Zheng

et al.

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(38), P. 15653 - 15660

Published: Sept. 14, 2021

A hydrophobic light-driven rotary motor is functionalized with two 18-crown-6 macrocycles and incorporated into phospholipid bilayers. In the presence of this molecular construct, fluorescence assays patch clamp experiments show formation selective alkali ion channels through membrane. Further, they reveal a strongly accelerated transport mechanism under light irradiation. This increase fractional activity (up to 400%) attributed out-of-equilibrium actuation dynamics motors, which help overcome activation energy necessary achieve translocation ions between along artificial channels.

Language: Английский

Citations

56