Supramolecular phthalocyanine assemblies‐enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Feb. 1, 2024

Abstract Phototherapeutic nanoplatforms that combine photodynamic therapy (PDT) and photothermal (PTT) with the guidance of photoacoustic (PA) imaging are an effective strategy for treatment tumors, but establishing a universal method this has been challenging. In study, we present supramolecular assembly based on Förster resonance energy transfer to construct nanostructured phototherapeutic agent (PcDA) via anion cation interaction between two water‐soluble phthalocyanine ramifications, PcD PcA. This approach promotes absorption energy, thus enhancing generation reactive oxygen species (ROS) heat by PcDA, improving its therapeutic efficacy, overcoming low photon utilization efficiency conventional PSs. Notably, after intravenous injection neoplastic sites could be clearly visualized using PA imaging, signal‐to‐liver ratio as high 11.9. Due these unique features, PcDA exhibits excellent antitumor efficacy in preclinical model at dose light irradiation. study offers general development efficient agents simultaneous effect PDT PTT against tumors assistance imaging.

Language: Английский

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Self-assembly strategies of organic small-molecule photosensitizers for photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215863 - 215863

Published: April 5, 2024

Language: Английский

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Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(37)

Published: April 23, 2024

Abstract Breast cancer stem cells (CSCs) are responsible for the occurrence, resistance, recurrence, invasion, and metastasis of tumors. However, even trace amounts CSCs may lead to tumor resistance which fundamentally reduces therapeutic efficiency numerous anticancer drugs. Thus, development a agent that can reduce tumorigenicity overcome recurrence is essential. Here novel multifunctional prodrug T‐P reported as photosensitizer, links phenothiazine drug with synthesized aggregation‐induced emission photosensitizer T‐C via an ester bond. Importantly, this found be able induce pyroptosis breast well activate their death pathway protein phosphatase 2A inhibit systemic anti‐tumor effects. rapidly target mitochondria overlap lysosomes after mitochondrial escape, it cause lysosomal dysfunction. It releases reactive oxygen species through photoactivation, triggering pyroptosis‐mediated strong immune response. On 5th day in vivo therapy cancer, primary eliminated growth distant tumors also inhibited. This research would provide impetus new strategy CSCs‐targeted photoimmunotherapy beyond.

Language: Английский

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Nitric Oxide-Producing Multiple Functional Nanoparticle Remodeling Tumor Microenvironment for Synergistic Photodynamic Immunotherapy against Hypoxic Tumor

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

The treatment of pancreatic cancer faces significant challenges due to connective tissue hyperplasia and severe hypoxia. Unlike oxygen-dependent Type II photosensitizers, I photosensitizers can produce a substantial amount reactive oxygen species, even under hypoxic conditions, making them more suitable for photodynamic therapy cancer. However, the dense extracellular matrix limits penetration efficiency presence immunosuppressive cells in tumor microenvironment reduces therapeutic effect. To address these challenges, we designed photoimmunotherapeutic M1@PAP nanoparticles composed photosensitizer anti-PD-L1 siRNA (siPD-L1), which was encapsulated into M1 macrophage membrane vesicles. In this system, pyropheophorbide-a (PPA) covalently conjugated poly-l-arginine (Arg9). Notably, it capable generating sufficient superoxide anions thereby functioning as photosensitizer. Furthermore, Arg9 acted nitric oxide (NO) donor, enhancing nanophotosensitizer by inhibiting cancer-associated fibroblast (CAF) activation decomposing matrix. Additionally, vesicles provided active targeting capabilities reeducated immunosuppressed M2 macrophages. reversal further promoted efficacy immunotherapy, showing great potential synergistic immunotherapy against tumor.

Language: Английский

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Reshaping the Tumor Immune Microenvironment Based on a Light‐Activated Nanoplatform for Efficient Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(11)

Published: Dec. 29, 2021

The immunosuppressive tumor microenvironment (TME) always causes poor antitumor immune efficacy, prone to relapse and metastasis. Herein, novel poly(vinylpyrrolidone) (PVP) modified BiFeO3 /Bi2 WO6 (BFO/BWO) with a p-n type heterojunction is constructed for reshaping the TME. Reactive oxygen species can be generated under light activation by well-separated hole (h+ )-electron (e- ) pairs owing in BFO/BWO-PVP NPs. Interestingly, h+ trigger decomposition of H2 O2 generate alleviating hypoxia, which not only sensitizes photodynamic therapy (PDT) radiotherapy (RT), but also promotes tumor-associated macrophages (TAMs) polarization from M2 M1 phenotype, beneficial decrease expression HIF-1α. Importantly, such light-activated nanoplatform, combining RT efficiently activate recruit cytotoxic T lymphocytes infiltrate tissues, as well stimulate TAMs dramatically reverse TME into an immunoactive one, further boost memory responses. Moreover, NPs present high performance computed tomography imaging contrast. Taken together, this work offers paradigm achieving self-supply inorganic nanoagents effective inhibition cancer metastasis recurrence.

Language: Английский

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