Engineering of two thiamine diphosphate-dependent enzymes for the regioselective condensation of C1-formaldehyde into C4-erythrulose

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127674 - 127674

Published: Oct. 25, 2023

Language: Английский

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Borohydride Compounds Catalyze the Selective 4e^– Reduction of CO₂ with 9-BBN

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 12187 - 12196

Published: Aug. 22, 2024

The selective double hydroboration of CO2 into bis(boryl)acetal (BBA) is a challenging yet appealing reduction process since BBA can be used as versatile C1 and Cn sources for the synthesis value-added products. In present study, we demonstrate that simple borohydride compounds are efficient catalysts when using 9-borabicyclo(3.3.1)nonane (9-BBN) reductant. experimental theoretical investigations show while species catalyzes first step formoxyborane (2e– intermediate), observed 4e– selectivity mostly due to ability 9-BBN reduce without catalyst. Notably, 0.2 mol % LiH2BBN catalyzed with reductant corresponding in 77% yield TON TOF 385 196 h–1, respectively. simplicity contrasts more elaborate catalytic systems so far CO2.

Language: Английский

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A cell-free artificial anabolic pathway for direct conversion of CO₂ to ethanol

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(22), P. 9069 - 9074

Published: Jan. 1, 2023

A cell-free anabolic pathway for direct conversion of CO 2 to ethanol in a carbon-conserved and ATP-independent manner is proposed by constructing assembling activation, formaldehyde → acetyl-CoA, synthesis modules.

Language: Английский

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A Multienzyme Cascade Pathway Immobilized in a Hydrogen‐Bonded Organic Framework for the Conversion of CO₂

Small, Journal Year: 2023, Volume and Issue: 20(14)

Published: Nov. 22, 2023

Abstract The reduction of carbon dioxide to valuable chemicals through enzymatic processes is regarded as a promising approach for the emissions. In this study, an in vitro multi‐enzyme cascade pathway constructed conversion CO 2 into dihydroxyacetone (DHA). This pathway, known FFFP, comprises formate dehydrogenase (FDH), formaldehyde (FaldDH), formolase (FLS), and phosphite (PTDH), with PTDH serving critical catalyst regenerating coenzyme NADH. Subsequently, immobilization FFFP within hydrogen‐bonded organic framework (HOF‐101) accomplished situ. A 1.8‐fold increase DHA yield observed FFFP@HOF‐101 compared free pathway. enhancement can be explained by fact that FFFP@HOF‐101, enzymes are positioned sufficiently close one another, leading elevation local concentration intermediates improvement mass transfer efficiency. Moreover, displays high degree stability. addition establishment effective production method, innovative concepts tailored synthesis fine compounds from utilization various developments generated work.

Language: Английский

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Multienzyme-catalyzed processes in asymmetric synthesis: state of the art and future trends

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 371 - 402

Published: Jan. 1, 2024

Language: Английский

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