High‐Throughput Screening and General Synthesis Strategy of Single‐Atom Nanozymes for Oral Squamous Cell Carcinoma Therapy DOI Open Access

Ji Shen,

Guan-Meng Zhang,

Zedong Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Single‐atom nanozymes (SAzymes), with their superior enzyme‐like catalytic activity, have emerged as promising candidates for oncology therapeutics. The well‐defined structures of SAzymes make them well predictable by experiences and theoretical calculation. However, the effects metal center species coordination environments on activity are variable, screening artificial experiments is challenging. High‐throughput can rapidly select optimal thus better application in tumor therapy highly desirable. Herein, a “high‐throughput screening‐SAzymes structures” system established efficient drug preparation density functional theory oxidase‐like processes screened differences brought about different metals environments. Through this process, transition (Mn, Fe, Co, Ni) active centers synthesized then tested multi‐enzyme activities. It found that SAzyme Co exhibited best further showed good anti‐oral squamous cell carcinoma properties both vitro vivo. This study opens up new avenue rational design oral cancer combining computational experimental validation.

Language: Английский

Oxygen-bridging Fe, Co dual-metal dimers boost reversible oxygen electrocatalysis for rechargeable Zn–air batteries DOI Creative Commons
Qixing Zhou, Wendan Xue, Xun Cui

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(30)

Published: July 18, 2024

Rechargeable zinc–air batteries (ZABs) are regarded as a remarkably promising alternative to current lithium-ion batteries, addressing the requirements for large-scale high-energy storage. Nevertheless, sluggish kinetics involving oxygen reduction reaction (ORR) and evolution (OER) hamper widespread application of ZABs, necessitating development high-efficiency durable bifunctional electrocatalysts. Here, we report atom–bridged Fe, Co dual-metal dimers (FeOCo-SAD), in which active site Fe–O–Co–N 6 moiety boosts exceptional reversible activity toward ORR OER alkaline electrolytes. Specifically, FeOCo-SAD achieves half-wave potential ( E 1/2 ) 0.87 V an overpotential 310 mV at density 10 mA cm –2 OER, with gap (Δ only 0.67 V. Meanwhile, manifests high performance peak power 241.24 mW −2 realistic rechargeable ZABs. Theoretical calculations demonstrate that introduction bridge dimer induced charge spatial redistribution around Fe atoms. This enhances activation optimizes adsorption/desorption dynamics intermediates. Consequently, energy barriers effectively reduced, leading strong promotion intrinsic OER. work suggests oxygen-bridging offer prospects significantly enhancing electrocatalysis creating innovative catalysts exhibit synergistic effects electronic states.

Language: Английский

Citations

21
Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity DOI Creative Commons
Shengjie Wei, Wenjie Ma, Minmin Sun

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 12, 2024

Constructing atom-pair engineering and improving the activity of metal single-atom nanozyme (SAzyme) is significant but challenging. Herein, we design Zn-SA/CNCl SAzyme by simultaneously constructing Zn-N4 sites as catalytic Zn-N4Cl1 regulator. The regulators effectively boost peroxidase-like activities sites, resulting in a 346-fold, 1496-fold, 133-fold increase maximal reaction velocity, constant efficiency, compared to Zn-SA/CN without with excellent inhibits tumor cell growth vitro vivo. density functional theory (DFT) calculations reveal that facilitate adsorption *H2O2 re-exposure thus improve rate. This work provides rational effective strategy for engineering. Designing enhancing performance nanozymes (SAzymes) through important yet difficult. Here authors develop concurrently creating regulators.

Language: Английский

Citations

19
Electroreduction-driven distorted nanotwins activate pure Cu for efficient hydrogen evolution DOI

Zhe Li,

Yueshuai Wang,

Hui Liu

et al.

Nature Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

5
Recent Advances in Single‐Atom Catalysts for Photoelectrocatalytic Water Splitting DOI Creative Commons
Jiao Yang, Xiaoyang Zheng, Syed Shoaib Ahmad Shah

et al.

Carbon Energy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

ABSTRACT Hydrogen is a highly promising energy carrier because of its renewable and clean qualities. Among the different methods for H 2 production, photoelectrocatalysis (PEC) water splitting has garnered significant interest, thanks to abundant perennial solar energy. Single‐atom catalysts (SACs), which feature well‐distributed atoms anchored on supports, have gained great attention in PEC their unique advantages overcoming limitations conventional reactions. Herein, we comprehensively review SAC‐incorporated photoelectrocatalysts efficient splitting. We begin by highlighting benefits SACs improving charge transfer, catalytic selectivity, activity, address Next, provide comprehensive overview established synthetic techniques optimizing properties SACs, along with modern characterization confirm structures. Finally, discuss challenges future directions basic research advancements, providing insights guidance this developing field.

Language: Английский

Citations

3
High‐Throughput Screening and General Synthesis Strategy of Single‐Atom Nanozymes for Oral Squamous Cell Carcinoma Therapy DOI Open Access

Ji Shen,

Guan-Meng Zhang,

Zedong Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Single‐atom nanozymes (SAzymes), with their superior enzyme‐like catalytic activity, have emerged as promising candidates for oncology therapeutics. The well‐defined structures of SAzymes make them well predictable by experiences and theoretical calculation. However, the effects metal center species coordination environments on activity are variable, screening artificial experiments is challenging. High‐throughput can rapidly select optimal thus better application in tumor therapy highly desirable. Herein, a “high‐throughput screening‐SAzymes structures” system established efficient drug preparation density functional theory oxidase‐like processes screened differences brought about different metals environments. Through this process, transition (Mn, Fe, Co, Ni) active centers synthesized then tested multi‐enzyme activities. It found that SAzyme Co exhibited best further showed good anti‐oral squamous cell carcinoma properties both vitro vivo. This study opens up new avenue rational design oral cancer combining computational experimental validation.

Language: Английский

Citations

2