Multi-Mimic Activities of Co3O4 Nanopolyhedrons and Application in Regulating the Content of Intracellular Hydrogen Peroxide/Oxygen DOI

Yu Zhu,

Jun Yan, Jing Liu

et al.

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(10), P. 15102 - 15114

Published: Oct. 10, 2022

Herein, Co3O4 nanopolyhedrons with multi-mimics of peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, and glutathione (GPx)-like activities were developed utilized in the application regulating level cellular oxygen hydrogen peroxide combined polydopamine (PDA). It was found that multi-mimic can be controlled by pH OXD- POD-like best when 4 but became weak under weakly acidic or neutral conditions. Meanwhile, CAT-like activity conditions, GPx-like better conditions than According to high especially at tumor cell microenvironment, catalytically transform H2O2 into O2 without interferences from other mimic activities. After coating PDA, Co3O4@PDA good biocompatibility dispersion also catalyzed produce microenvironment efficiency. The corresponding fluorescent probes used monitor process, main mechanisms investigated through fluorescence spectra confocal microscopy. This work not only verifies multi-enzyme properties provides a nanomaterial for regulation content cells utilizing enzyme property nanomaterial. is considered concentration variation active small molecules regulated nanoenzymes may provide some basis cancer diagnosis treatment.

Language: Английский

Universal Chiral Nanopaint for Metal Oxide Biomaterials DOI

Wookjin Jung,

Dongkyu Lee,

Hohyeon Kim

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Chirality is widespread in nature and governs the properties of various materials including inorganic nanomaterials. However, previously reported chiral have been limited to a handful compositions owing physicochemical restrictions that impart chirality. Herein, nanopaint applicable diverse presented. Various metal oxide nanoparticles (NPs) show chiroptical after coating with our nanopaint, while maintaining their properties, such as magnetic properties. The combination magnetism chirality brings biomedical functionalities NPs, anticancer hyperthermia treatment. In vitro, d-nanopainted iron NPs showed more than 50% higher cellular uptake compared l-nanopainted this was due enantiospecific interaction between receptors on cell surface NPs. vivo, 4-fold superior efficiency by improved adsorption tumors. These may provide potential synthesis strategies for biomaterials, which exhibit elaborate combinations intrinsic physical extrinsic enantioselective variety applications.

Language: Английский

Citations

0
tablePolymeric Nanocomposites-based Advanced Coatings for Antimicrobial and Antiviral Applications: A Comprehensive Overview DOI Creative Commons

Rachid Amrhar,

Jaspal Singh, Mostafa Eesaee

et al.

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100497 - 100497

Published: March 1, 2025

Language: Английский

Citations

0
Mo-ions doping impact on structural modifications and electrochemical performance of Mo-Co(OH)2 dandelion nanostructures DOI

Qurat-ul-Aain,

Ghulam Nabi,

Hammad Ali

et al.

Materials Science and Engineering B, Journal Year: 2025, Volume and Issue: 318, P. 118309 - 118309

Published: April 11, 2025

Language: Английский

Citations

0
Chiral nanomaterials: Emerging therapeutics in the field of medicinal chemistry DOI

Suresh Patnaik Pakki,

Shubhank Goyal,

Chinmay Mittal

et al.

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Multi-Mimic Activities of Co3O4 Nanopolyhedrons and Application in Regulating the Content of Intracellular Hydrogen Peroxide/Oxygen DOI

Yu Zhu,

Jun Yan, Jing Liu

et al.

ACS Applied Nano Materials, Journal Year: 2022, Volume and Issue: 5(10), P. 15102 - 15114

Published: Oct. 10, 2022

Herein, Co3O4 nanopolyhedrons with multi-mimics of peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, and glutathione (GPx)-like activities were developed utilized in the application regulating level cellular oxygen hydrogen peroxide combined polydopamine (PDA). It was found that multi-mimic can be controlled by pH OXD- POD-like best when 4 but became weak under weakly acidic or neutral conditions. Meanwhile, CAT-like activity conditions, GPx-like better conditions than According to high especially at tumor cell microenvironment, catalytically transform H2O2 into O2 without interferences from other mimic activities. After coating PDA, Co3O4@PDA good biocompatibility dispersion also catalyzed produce microenvironment efficiency. The corresponding fluorescent probes used monitor process, main mechanisms investigated through fluorescence spectra confocal microscopy. This work not only verifies multi-enzyme properties provides a nanomaterial for regulation content cells utilizing enzyme property nanomaterial. is considered concentration variation active small molecules regulated nanoenzymes may provide some basis cancer diagnosis treatment.

Language: Английский

Citations

18