Copper-based metal–organic frameworks for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 305, P. 102686 - 102686

Published: April 29, 2022

Language: Английский

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Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114643 - 114643

Published: April 7, 2023

Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, reduced performance drugs is predominantly due to inherent over expression ATP-binding cassette (ABC) transporter proteins on cell membrane, resulting deprived uptake drugs, augmenting drug detoxification, and DNA repair. In addition physiological abnormalities extensive blood flow, MDR phenotypes exhibit improved apoptotic threshold efflux efficiency. These severe consequences have substantially directed researchers fabrication advanced strategies, such as co-delivery along with generations inhibitors, augmented dosage regimens frequency administration, well combinatorial treatment options, among others. this review, we emphasize different reasons mechanisms responsible for cancer, including but not limited known mediated by permeability glycoprotein (P-gp) other pumps, uptake, altered repair, targets, Further, an emphasis specific cancers that share pathogenesis executing effluxed common provided. Then, aspects related nanomaterials-based supramolecular programmable designs (organic- inorganic-based materials), physical approaches (light- ultrasound-based therapies), are discussed, highlighting unsolved issues future advancements. Finally, summarize review interesting perspectives trends, exploring further opportunities overcome MDR.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Recent advances in metal-organic frameworks: Synthesis, application and toxicity

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 902, P. 165944 - 165944

Published: Aug. 4, 2023

Language: Английский

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Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 72, P. 101018 - 101018

Published: Nov. 11, 2023

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role copper and triggered in pathogenesis cancers have attracted attentions. has garnered enormous interest cancer research communities because its great potential for therapy. Copper-based treatment exerts an inhibiting tumor growth may open door chemotherapy-insensitive tumors. In this review, we provide critical analysis on homeostasis dysregulation development progression cancers. Then core molecular mechanisms cuproptosis discussed, followed summarizing current understanding copper-based agents (copper chelators, ionophores, complexes-based dynamic therapy) treatment. Additionally, summarize emerging data ionophores to subdue chemotherapy resistance different types We also review small-molecule compounds nanoparticles (NPs) that kill cells inducing cuproptosis, which will shed new light anticancer drugs through future. Finally, important concepts pressing questions future should be focused were discussed. This article suggests targeting could novel antitumor therapy strategy overcome drug resistance.

Language: Английский

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Potential of Copper and Copper Compounds for Anticancer Applications

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 234 - 234

Published: Feb. 3, 2023

Inducing cancer cell death has always been a research hotspot in life sciences. With the continuous deepening and diversification of related research, potential value metal elements inducing explored. Taking iron as an example, ferroptosis, mainly characterized by increasing load driving production large amounts lipid peroxides eventually leading to death, recently attracted great interest community. After iron, copper, trace element, received extensive attention especially tumor death. Copper its complexes can induce autophagy or apoptosis cells through variety different mechanisms action (activation stress pathways, arrest cycle, inhibition angiogenesis, cuproptosis, paraptosis), which are promising therapy have become new hotspots treatment research. This article reviews main applications novel copper compound-induced focusing on compounds their anticancer applications.

Language: Английский

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Surface Energy Mediated Sulfur Vacancy of ZnIn₂S₄ Atomic Layers for Photocatalytic H₂O₂ Production

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(35)

Published: May 14, 2023

Abstract Constructing rich defect active site structure for material design is still a great challenge. Herein, simple surface engineering strategy demonstrated to construct one‐unit‐cell ZnIn 2 S 4 atomic layers with the modulated energy of vacancy. Rich can regulate and control vacancy, which ensures sites, higher charge density effective carrier transport. As result, affords an obvious enhancement in H O productive rate 1592.04 µmol g −1 h , roughly 14.58 times superior that poor energy. Moreover, situ infrared diffuse reflection spectrum indicates vacancy as oxygen reduction reaction responsible critical intermediate *O − *OOH, corresponding two‐electron reaction. This study provides valuable insight guidance constructing controllably defects achieve highly efficient production.

Language: Английский

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Tumor microenvironment-oriented MOFs for chemodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 484, P. 215098 - 215098

Published: March 14, 2023

Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic (CDT) based Fenton/Fenton-like reactions a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals (OH) through exploitation of transition metal ions catalysts acidic microenvironment (TME) suitable effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise CDT account their unique properties. Among them, stimuli-responsive nature and porosity MOFs make them ideal TME-targeted cargo delivery. In addition, ability to select appropriate organic ligands makes it possible prepare intrinsic antitumor activity. This review primarily summarizes latest progress application microenvironment-oriented CDT, including or chemodynamic Furthermore, remaining challenges suggestions future applications are also presented.

Language: Английский

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Self‐Assembled Copper‐Based Nanoparticles for Glutathione Activated and Enzymatic Cascade‐Enhanced Ferroptosis and Immunotherapy in Cancer Treatment

Small, Journal Year: 2023, Volume and Issue: 19(35)

Published: April 28, 2023

As an emerging cancer treatment strategy, ferroptosis is greatly restricted by excessive glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) generation efficiency. Here, this work designs self-assembled copper-alanine nanoparticles (CACG) loaded with glucose oxidase (GOx) cinnamaldehyde (Cin) for situ activated enzymatic cascade-enhanced immunotherapy. In response to GSH-rich acidic TME, CACG allows effectively co-deliver Cu2+ , Cin, GOx into tumors. Released Cin consumes GSH through Michael addition, accompanying the reduction of Cu+ further depletion. With cascade -catalyzed Fenton reactions enzyme-catalyzed GOx, could get rid restriction insufficient hydrogen peroxide leading a robust constant ROS. high efficiency depletion ROS production, significantly enhanced vivo. Moreover, elevated oxidative stress triggers immune responses promoting dendritic cells maturation T cell infiltration. The vivo results prove that efficiently inhibit growth 4T1 tumor-bearing mouse model without causing obvious systemic toxicity, suggesting great potential enhancing immunotherapy effective treatment.

Language: Английский

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Recent progress in MOFs-based nanozymes for biosensing

Nano Research, Journal Year: 2023, Volume and Issue: 17(1), P. 39 - 64

Published: July 6, 2023

Language: Английский

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