Nanomedicine‐Enabled Chemical Regulation of Reactive X Species for Versatile Disease Treatments DOI
Xinyue Dai, Yujie Xie, Wei Feng

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 135(50)

Published: Sept. 1, 2023

Abstract Reactive X species (RXS), encompassing elements such as O, N, C, S, Se, Cl, Br, I, and H, play vital roles in cell biology physiological function, impacting cellular signal transduction, metabolic regulation, disease processes. The redox unbalance of RXS is firmly implicated an assortment pathological disorders, including cancer, diabetes, cardiovascular disease, neurodegenerative diseases. However, the intricate nature multifactorial dependence pose challenges comprehending precisely modulating their biological behavior. Nanomaterials with distinct characteristics biofunctions offer promising avenues for generating or scavenging to maintain homeostasis advance therapy. This minireview provides a tutorial summary relevant chemistry specific mechanisms governing different RXS, focusing on stress responses, role nanomedicine generation elimination. associated chemically regulating diverse treatments are further discussed along future prospects, aiming facilitate clinical translation RXS‐based open new improved therapeutic interventions.

Language: Английский

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy DOI Creative Commons

Xumeng Wu,

Ziqi Zhou, Kai Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

Citations

28
Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology DOI
Tommaso Angelone, Carmine Rocca, Vincenzo Lionetti

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 369 - 432

Published: Feb. 1, 2024

Physiological levels of reactive oxygen and nitrogen species (ROS/RNS) function as fundamental messengers for many cellular developmental processes in the cardiovascular system. ROS/RNS involved cardiac redox-signaling originate from diverse sources, their are tightly controlled by key endogenous antioxidant systems that counteract accumulation. However, dysregulated redox-stress resulting inefficient removal leads to inflammation, mitochondrial dysfunction, cell death, contributing development progression disease (CVD).

Language: Английский

Citations

18
Novel ray of hope for diabetic wound healing: Hydrogen sulfide and its releasing agents DOI Creative Commons

Xinyi Shi,

Haonan Li,

Fengrui Guo

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 58, P. 105 - 115

Published: May 27, 2023

Diabetes mellitus (DM) is a long-term metabolic disease accompanied by difficulties in wound healing placing severe financial and physical burden on patients. As one of the important signal transduction molecules, both endogenous exogenous hydrogen sulfide (H2S) was found to promote diabetic recent studies. H2S at physiological concentrations can not only cell migration adhesion functions, but also resist inflammation, oxidative stress inappropriate remodeling extracellular matrix. The purpose this review summarize current research function all stages, propose future directions. In review, first, various factors affecting under pathological conditions vivo generation pathway are briefly introduced. Second, how may improve categorized described. Finally, we discuss relevant donors new dosage forms, analyze reveal characteristics many typical donors, which provide ideas for development H2S-released agents healing.

Language: Английский

Citations

21
New Insights into Oxidative and Reductive Stress Responses and Their Relation to the Anticancer Activity of Selenium-Containing Compounds as Hydrogen Selenide Donors DOI Creative Commons
Agnieszka Krakowiak, Sylwia Pietrasik

Biology, Journal Year: 2023, Volume and Issue: 12(6), P. 875 - 875

Published: June 17, 2023

Redox balance is important for the homeostasis of normal cells, but also proliferation, progression, and survival cancer cells. Both oxidative reductive stress can be harmful to In contrast stress, therapeutic opportunities underlying mechanisms in cancer, as well how cells respond have received little attention are not characterized. Therefore, there recent interest understanding selective induction may influence treatment disease progression cancer. There question stress. Selenium compounds been shown chemotherapeutic effects against their anticancer mechanism thought related formation metabolites, including hydrogen selenide (H2Se), which a highly reactive reducing molecule. Here, we highlight reports on molecular recognize (1) through different types selenium generate H2Se (2) thus selectively affect under controlled conditions, effects.

Language: Английский

Citations

21
Taming the Dichalcogenides: Isolation, Characterization, and Reactivity of Elusive Perselenide, Persulfide, Thioselenide, and Selenosulfide Anions DOI

Keyan Li,

Lev N. Zakharov, Michael D. Pluth

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(24), P. 13435 - 13443

Published: June 9, 2023

Reactive sulfur species (RSS) and reactive selenium (RSeS) play integral roles in hydrogen sulfide (H2S) selenide (H2Se) biological signaling pathways, dichalcogenide anions are proposed transient intermediates that facilitate a variety of biochemical transformations. Herein we report the selective synthesis, isolation, spectroscopic structural characterization, fundamental reactivity persulfide (RSS-), perselenide (RSeSe-), thioselenide (RSSe-), selenosulfide (RSeS-) anions. The isolated chalcogenides do not rely on steric protection for stability have profiles analogous to cysteine (Cys). Simple reduction S8 or Se by potassium benzyl thiolate (KSBn) selenolate (KSeBn) presence 18-crown-6 afforded [K(18-crown-6)][BnSS] (1), [K(18-crown-6)][BnSeSe] (2), [K(18-crown-6][BnSSe] (3), [K(18-crown-6][BnSeS] (4). chemical structure each was confirmed X-ray crystallography solution-state 1H, 13C, 77Se NMR spectroscopy. To advance our understanding these species, demonstrated 1-4 PPh3 readily generates E═PPh3 (E: S, Se), 1, 3, 4 DTT produces HE-/H2E. Furthermore, react with CN- produce ECN-, which is consistent detoxifying effects Rhodanese enzyme. Taken together, this work provides new insights into inherent characteristics dichalcogenides relevant biology advances properties

Language: Английский

Citations

20
H2Se-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence DOI
Fan Yang, Rui Shu, Wenyu Dai

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122659 - 122659

Published: June 7, 2024

Language: Английский

Citations

5
Reactive sulfur and selenium species in the regulation of bone homeostasis DOI Creative Commons
Annie K. Gilbert, Turner D. Newton, Marian H. Hettiaratchi

et al.

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 190, P. 148 - 157

Published: Aug. 5, 2022

Language: Английский

Citations

21
S-Se-S type molecule: A bactericidal promoter against H<sub>2</sub>S-induced antibiotic resistance DOI
Mengnan Liu,

Fanqiang Bu,

Guofeng Li

et al.

The Innovation Life, Journal Year: 2024, Volume and Issue: 2(3), P. 100076 - 100076

Published: Jan. 1, 2024

<p>The hydrogen sulfide (H<sub>2</sub>S)-induced defense system is a crucial bacterial pathway that leads to antibiotic resistance. Herein, unique S-Se-S molecule, namely, 2,2’-(selenobis(sulfanediyl))diacetic acid (Se-Acid), first reported relieve H<sub>2</sub>S-induced resistance by acting as selenide (H<sub>2</sub>Se) donor. The molecular structure was formed using the carboxyl terminal an electron acceptor. After being endocytosed cells, Se-Acid effectively released H<sub>2</sub>Se molecules reacting with glutathione (GSH). increased endocytosis of antibiotics promoting membrane permeability. Moreover, reactivated respiratory flux functioning H<sub>2</sub>S disguiser. synergistic effect and Gentamicin (Gm) on antibiotic-resistant MRSA proven MRSA<sup>S+</sup> wound infection model. Our results establish type potential tools for addressing challenge reducing risk resistance.</p>

Language: Английский

Citations

4
Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? DOI Creative Commons
Cristina Morán-Serradilla, Eduardo Angulo-Elizari, Andreina Henriquez-Figuereo

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(9), P. 874 - 874

Published: Sept. 16, 2022

Selenium (Se) is an essential element for human health as it involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents the prevention and treatment some diseases. It widely recognized that activity related to multiple factors, such its chemical form, dose, metabolism. The understanding complex biochemistry necessary has been demonstrated metabolites molecules used ones exert biological activity. Therefore, aim this review summarize recent information about most remarkable acknowledged effects: hydrogen selenide (HSe−/H2Se) methylselenol (CH3SeH). In addition, special attention paid main seleno-containing precursors these derivatives their role pathologies.

Language: Английский

Citations

17
Nanomedicine‐Enabled Chemical Regulation of Reactive X Species for Versatile Disease Treatments DOI
Xinyue Dai, Yujie Xie, Wei Feng

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(50)

Published: Sept. 1, 2023

Abstract Reactive X species (RXS), encompassing elements such as O, N, C, S, Se, Cl, Br, I, and H, play vital roles in cell biology physiological function, impacting cellular signal transduction, metabolic regulation, disease processes. The redox unbalance of RXS is firmly implicated an assortment pathological disorders, including cancer, diabetes, cardiovascular disease, neurodegenerative diseases. However, the intricate nature multifactorial dependence pose challenges comprehending precisely modulating their biological behavior. Nanomaterials with distinct characteristics biofunctions offer promising avenues for generating or scavenging to maintain homeostasis advance therapy. This minireview provides a tutorial summary relevant chemistry specific mechanisms governing different RXS, focusing on stress responses, role nanomedicine generation elimination. associated chemically regulating diverse treatments are further discussed along future prospects, aiming facilitate clinical translation RXS‐based open new improved therapeutic interventions.

Language: Английский

Citations

11