ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
14(2), P. 628 - 636
Published: Dec. 28, 2023
Although
the
asymmetric
hydroalkoxylation
of
1,3-dienes
has
been
achieved
recently,
development
a
modular
and
mechanistically
distinct
strategy
for
concurrently
introducing
an
alkoxyl
group
another
chiral
moiety
into
remains
to
be
disclosed.
Presented
herein
is
palladium(0)-π-Lewis
base-catalyzed
hydroxymethylative
etherification
reaction
1,3-dienes,
isatins,
aliphatic
alcohols,
proceeding
through
cascade
vinylogous
addition
allylic
sequence.
This
three-component
exhibits
broad
substrate
scope
good
functionality
tolerance
under
mild
catalytic
conditions,
generally
furnishing
structurally
diverse
1,3-diol
derivatives
bearing
two
stereogenic
centers
with
moderate-to-high
levels
diastereo-
enantioselectivity,
which
can
further
converted
valuable
frameworks
higher
molecular
complexity.
In
addition,
few
control
experiments
were
conducted
elucidate
process.
