Shedding Light on Lysosomal Malondialdehyde Affecting Vitamin B12 Transport during Cerebral Ischemia/Reperfusion Injury DOI
Di Su, Ran Zhang, Xin Wang

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(41), P. 22609 - 22619

Published: Oct. 7, 2023

Cerebral ischemia-reperfusion injury (CIRI) is often accompanied by upregulation of homocysteine (Hcy). Excessive Hcy damages cerebral vascular endothelial cells and neurons, inducing neurotoxicity even neurodegeneration. Normally, supplementation vitamin B12 an ideal intervention to reduce Hcy. However, therapy clinically inefficacious for CIRI. Considering oxidative stress closely related CIRI, the lysosome pivotal site transport. Lysosomal might hinder transport B12. Whether lysosomal malondialdehyde (lysosomal MDA), as authoritative biomarker stress, interferes with has not been elucidated. This ascribed absence effective methods real-time in situ measurement MDA within living brains. Herein, a fluorescence imaging agent, Lyso-MCBH, was constructed specifically monitor entering brain targeting lysosome. Erupting level brains mice under CIRI first observed using Lyso-MCBH. found affect efficacy blocking from cytoplasm. More importantly, expression function transporter LMBD1 were proved be associated excessive MDA. Altogether, revealing MDA-LMBD1 axis provides cogent interpretation inefficacy which could prospective therapeutic target.

Language: Английский

Flexible near-infrared organic photodetectors for emergent wearable applications DOI Creative Commons
Zehao Wang, Simin Cheng, Kenjiro Fukuda

et al.

Wearable electronics., Journal Year: 2024, Volume and Issue: 1, P. 53 - 77

Published: May 13, 2024

With the evolution of Industry 4.0, next-generation wearable devices have come under spotlight, where organic electronics are playing an important role due to their flexible form factor, high performance, and integration capability. Designed conform soft dynamic surfaces, photodetectors (OPDs) integrated arrays stand out for application potential in non-invasive biosensing bio-imaging, with inherent advantages mitigating motion artifacts – a notable limitation traditional, rigid photodetector systems. Leveraging near-infrared (NIR) spectrum's capability deep skin penetration minimal scattering human tissues, NIR OPDs especially capable precise diagnostics enhanced signal quality. The adaptable factor further broadens applications human-environment interaction, marking shift towards more responsive intelligent technologies. This review summarizes latest challenges breakthroughs OPDs, emphasizing effective strategies toward high-performance device units We discuss remaining outlook on vast reshaping our interaction surroundings.

Language: Английский

Citations

14
Golgi-targeting viscosity probe for the diagnosis of Alzheimer’s disease DOI Creative Commons
Wenjing Wu,

Lingyu Zhao,

Yuanyuan Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 16, 2024

Abstract Early diagnosis and intervention of Alzheimer’s disease (AD) are particularly important to delay the pathological progression. Although fluorescent probes have been widely employed for investigating diagnosing AD, their biological applications significantly restricted due low penetration ability blood–brain barrier (BBB) in vivo. In this study, we reported first Golgi-targeted two-photon (TP) probe, DCM-DH, detecting viscosity Golgi apparatus. The probe was rationally designed exhibit superior analytical performance including high sensitivity, specific Golgi-targeting, efficient BBB ability, deep tissue (247 μm) brains AD model mice. Using demonstrated that fluorescence intensity human liver cancer cell (HepG2 cells) higher than normal (LO2 cells), brain mice increased significantly. We anticipate competent tool could be easily extended other biomarkers fundamental research on detrimental disease.

Language: Английский

Citations

10
Intramolecular Repulsive Interactions Enable High Efficiency of NIR-II Aggregation-Induced Emission Luminogens for High-Contrast Glioblastoma Imaging DOI

Fulong Ma,

Zhiyuan Gao, Qian Jia

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Strategies to acquire high-efficiency luminogens that emit in the second near-infrared (NIR-II, 1000-1700 nm) range are still rare due impediment of energy gap law. Herein, a feasible strategy is pioneered by installing large-volume encumbrances confined space intensify repulsive interactions arising from overlapping electron densities. The experimental results, including smaller coordinate displacement, reduced reorganization energy, and suppressed internal conversion, demonstrate assist inhibition radiationless deactivation. Meanwhile, configuration hybridization form donor units transformed along with interactions, bringing about improved oscillator strength. A 3.8-fold higher luminescence efficiency realized via synergistic effect. Furthermore, endow NIR-II fluorophores highly twisted conformation, superior AIE activity, cascaded improvement fluorescence emission isolated molecules aggregates. By utilizing brain-targeting peptide functionalize nanoparticles, accurate detection high-contrast imaging orthotopic glioblastoma realized. This work not only explores fundamental principle handle intractable law but also provides potential applications bioimaging detection.

Language: Английский

Citations

1
Amphiphilic hemicyanine molecular probes crossing the blood-brain barrier for intracranial optical imaging of glioblastoma DOI Creative Commons
Wei Qin,

Honghui Li,

Jiali Chen

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(3)

Published: Jan. 15, 2025

Intracranial optical imaging of glioblastoma (GBM) is challenging due to the scarcity effective probes with blood-brain barrier (BBB) permeability and sufficient depth. Herein, we describe a rational strategy for designing crossing BBB based on an electron donor-π-acceptor system adjust lipid/water partition coefficient molecular weight probes. The amphiphilic hemicyanine dye (namely, IVTPO), which exhibits remarkable properties permeability, chosen as efficient fluorescence/photoacoustic probe in vivo real-time orthotopic GBM high resolution through intact skull. Abnormal leakage IVTPO adjacent developing tumor unambiguously observed at early stage development prior impairment integrity, assessed by commercial Evans blue (EB). Compared EB, demonstrates enhanced capability improved tumor-targeting efficacy. These results offer encouraging insights into medical diagnosis intracranial GBM.

Language: Английский

Citations

1
Exploring photo-excited states of aromatic sulfones for efficient near-infrared-activated photothermal cancer therapy DOI
Kazuya Yoshida, Toshiaki Suzuki, Yasuko Osakada

et al.

Bulletin of the Chemical Society of Japan, Journal Year: 2025, Volume and Issue: 98(1)

Published: Jan. 1, 2025

Abstract Near-infrared light activation enhances phototherapeutic efficacy due to deep-tissue penetration and minimal invasion. While near-infrared-phototherapeutic agents are widely studied, conventional designs often increase molecular size, affecting pharmacokinetics. This study elucidates the photo-excited states of sulfone-containing aromatic compounds as efficient near-infrared-activated photothermal for cancer therapy. We synthesized sulfone-rosamine (3 4) exhibiting strong optical absorption around 700 nm, attributed a unique orbital in LUMO. Compound 4, 35% smaller than near-infrared-dye molecules, such Cy5.5 (0.86 nm3/molecule), intracellular mobility. Upon photoexcitation, 4 undergoes rapid non-radiative relaxation, resulting remarkable effects photostability. Transient spectroscopy density functional theory calculations revealed mechanism involving deactivation after illumination, efficiently converting heat. The near-infrared-induced effect effectively killed various cell lines, including HeLa, MDA-MB-231, PCI-55. provides guidelines designing novel photodrugs with improved mobility, near-infrared responsiveness, photostability, introduces advancement treatment.

Language: Английский

Citations

1
A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF DOI Creative Commons
Lu Cao, Cong Meng, Yuying Li

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 12, 2024

Abstract To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression connective tissue growth factor (CTGF) in AD brain an upstream regulator amyloid-beta (Aβ) plaque, thus CTGF could be diagnostic biomarker than Aβ plaque. Herein, we develop a peptide-coated gold nanocluster that specifically targets with high affinity (KD ~ 21.9 nM). The probe can well penetrate blood-brain-barrier (BBB) APP/PS1 transgenic mice at early-stage (earlier 3-month-old) vivo, allowing non-invasive NIR-II imaging when there no appearance plaque deposition. Notably, this also applied to measuring on postmortem sections by multimodal analysis, including fluorescence imaging, peroxidase-like chromogenic and ICP-MS quantitation, which enables distinguishment between brains patients healthy people. This possesses great potential for precise before formation.

Language: Английский

Citations

8
Injectable‐Hydrogel‐Based Tissue Sealant for Hemostasis, Bacteria Inhibition, and Pro‐Angiogenesis in Organ Bleeding Wounds and Therapeutic Outcome Monitoring Via NIR‐II Optical Imaging DOI
Lihe Sun, Juan Ouyang,

Zunpan She

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 28, 2024

Abstract Sudden hemorrhage stemming from internal organ wounds poses a grave and potentially fatal risk if left untreated. Injectable‐hydrogel‐based tissue sealants featuring multiple actions, including fit‐to‐shape in situ gelation, rapid hemostasis, pro‐angiogenic, anti‐bacterial outcome tracking, are ideal for the management of trauma wounds. Herein, an injectable‐hydrogel sealant AN@CD‐PEG&TQ which consists four‐arm 4‐arm poly(ethylene glycol) (PEG‐SC) succinimidyl carbonate), AN@CD nanoprobe, two bioactive peptides (anti‐microbial peptide Tet213 pro‐angiogenic QK) is developed. Among them, nanoparticles form through host/guest complexation amino‐group‐containing β‐cyclodextrin adamantyl group, enabling biomarker (NO)‐activatable optoacoustic/NIR‐II: Near‐infrared second biological window fluorescent imaging. The ample ─NH2 groups on surface readily engage cross‐linking with ester located at ends PEG‐SC. This expedites gelation process without necessitating additional initiators or agents; thus, significantly enhancing both hydrogel's application convenience biocompatibility. Bioactive (Tet213 safeguard against possible bacterial infections, facilitate angiogenesis, eventually, improve healing. hydrogel‐based demonstrates superior therapeutic bioimaging performance various mouse models liver hemorrhage, gastric perforation, bacterial‐infected skin wound models, highlighting its potential as high‐performance bleeding management.

Language: Английский

Citations

7
Engineering aggregates of julolidine-substituted aza-BODIPY nanoparticles for NIR-II photothermal therapy DOI

Lulu Cao,

Yikun Li, Dongxiang Zhang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(12), P. 109735 - 109735

Published: March 8, 2024

Language: Английский

Citations

7
Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease DOI
Lei Wang, Tianyu Sun,

Tengfei Zhen

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 6793 - 6809

Published: March 28, 2024

Butyrylcholinesterase (BChE) is a promising biomarker and effective therapeutic target for Alzheimer's disease (AD). Herein, we designed BChE-activated near-infrared (NIR) probe,

Language: Английский

Citations

7
Acceptor-engineering tailored type-I photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics DOI
Jiangao Li, Niu Niu, Deliang Wang

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(8), P. 2647 - 2660

Published: June 26, 2024

Language: Английский

Citations

7