Hydrogel Wound Dressings Accelerating Healing Process of Wounds in Movable Parts

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6610 - 6610

Published: June 15, 2024

Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives

Language: Английский

---

Homo‐Dyad with Outer Hydration Layer Approach for Developing NIR‐II Chromophore of High Stability and Water‐Solubility as Injectable and Sprayable Optical Probe

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 8, 2024

Dyes with extended conjugate structures are the focus of extensive design and synthesis efforts, aiming to confer unique improved optical electronic properties. Such advancements render these dyes applicable across a wide spectrum uses, ranging from second-window near-infrared (NIR-II) bioimaging organic photovoltaics. Nevertheless, inherent benefits long conjugation often accompanied by persistent challenges like aggregation, fluorescence quenching, absorption blueshift, low stability poor water solubility. Herein, structural strategy termed "homo-dyad outer hydration layer" is introduced address problems, tailored for development imaging probes exhibiting absorption/emission wavelengths. This approach involves bringing two heptamethine cyanines together through flexible linker, forming homo-dyad structure, while strategically attaching four polyethylene glycol (PEG9) chains terminal heterocycles. imparts excellent solubility, biocompatibility, enhanced chemical, photo-, spectral dyes. Utilizing this strategy, biomarker-activatable probe (HD-FL-4PEG9-N) NIR-II fluorescent 3D multispectral optoacoustic tomography developed, its effectiveness in disease visualization. It can not only serve as an injectable acute kidney injury due high but also sprayable bacterial-infected wounds.

Language: Английский

---

Versatile hydrogel-based drug delivery platform for multimodal cancer therapy from bench to bedside

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102341 - 102341

Published: July 22, 2024

Language: Английский

---

Microneedle System with Biomarker-Activatable Chromophore as Both Optical Imaging Probe and Anti-bacterial Agent for Combination Therapy of Bacterial-Infected Wounds and Outcome Monitoring

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Wounds infected with bacteria, if left untreated, have the potential to escalate into life-threatening conditions, such as sepsis, which is characterized by widespread inflammation and organ damage. A comprehensive approach treating bacterial-infected wounds, encompassing control of bacterial infection, biofilm eradication, regulation, holds significant importance. Herein, a microneedle (MN) patch (FM@ST MN) has been developed, silk fibroin (SF) tannic acid-based hydrogel serving matrix. Encapsulated within MNs are AIEgen-based activatable probe (FQ-H2O2) NLRP3 inhibitor MCC950, optical reporter/antibacterial agent regulator, respectively. When applied onto in FM@ST MN penetrate biofilms gradually degrade, releasing FQ-H2O2 MCC950. The released responds endogenously overexpressed reactive oxygen species (H2O2) at wound site, generating chromophore FQ-OH emits noticeable NIR-II fluorescence optoacoustic signals, enabling real-time imaging for outcome monitoring; this also exhibits potent antibacterial capability due its dual positive charges shows negligible resistance. However, upon release, suppresses activation inflammasomes, thereby mitigating triggered infections facilitating healing. Furthermore, SF aids tissue repair regeneration promoting proliferation epidermal cells fibroblasts collagen synthesis. This system, free from antibiotics, promise solution monitoring bacterially wounds without associated risk antimicrobial

Language: Английский

---

Robust Luminescent Pyrene-Based Metal–Organic Framework Hydrogel as a pH-Responsive Fluorescence Emitter for Sensitive Immunoassay of Cardiac Troponin I

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(37), P. 15042 - 15049

Published: Sept. 2, 2024

Despite many luminescent advantages including outstanding absorption coefficient and high quantum yield, pyrene its derivatives have been suffering from a dramatic aggregation-caused quenching (ACQ) effect. Although the ACQ effect of pyrene-based fluorophores has restrained in pyrene-doped metal-organic frameworks (MOFs), low loading fluorescent (FL) units substantially impedes improved behaviors. Herein, MOFs hydrogel was synthesized with as unique organic linker blocks instead dopant MOFs. The gel matrix contributed to rigidifying location FL emitters achieving intensive emission stability therefore efficiently overcoming Furthermore, protonation remarkably decreased intensity, which endowed highly pH-responsive activity broad range (pH 4-10). Interestingly, glucose oxidase immobilized into ZIF-8 efficient quencher, catalyzing form gluconic acid thus drastically signal hydrogel. emitter-quencher pair successfully employed develop an ultrasensitive immunoassay platform for cardiac troponin I (as model analyte). limit detection 5.2 pg/mL (3σ). proof-of-principle study demonstrated thrilling auxiliary tailorable on boosting feasibility aqueous insoluble chromophores trace analysis.

Language: Английский

---

Acid-responsive contractile hyaluronic acid-based hydrogel loaded with ginsenoside Rg1 for hemostasis and promotion of gastric wound healing

Biomaterials, Journal Year: 2025, Volume and Issue: 321, P. 123320 - 123320

Published: April 5, 2025

Language: Английский

---

Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections

Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1042 - 1042

Published: Nov. 4, 2024

The extensive use of antibiotics during recent years has led to antimicrobial resistance development, a significant threat global public health. It is estimated that around 1.27 million people died worldwide in 2019 due infectious diseases caused by antibiotic-resistant microorganisms, according the WHO. 700,000 die each year worldwide, which expected rise 10 2050. Therefore, new and efficient antimicrobials against resistant pathogenic bacteria are urgently needed. Antimicrobial peptides (AMPs) present broad spectrum antibacterial effects considered potential tools for developing novel therapies combat infections. However, their clinical application currently limited instability, low selectivity, toxicity, bioavailability, resulting narrow therapeutic window. Here we describe an overview AMPs bacterial infections through nanoformulation. evaluates metal, polymeric, lipid AMP delivery systems as promising treatment infections, offering solution aforementioned limitations.

Language: Английский

---