Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(8)
Published: Nov. 21, 2023
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function-oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF-based
anticancer
nanomedicines
bringing
closer
to
trials.
Journal of Materials Chemistry A,
Journal Year:
2024,
Volume and Issue:
12(8), P. 4752 - 4760
Published: Jan. 1, 2024
We
report
herein
a
novel
pyrene-based
two-dimensional
supramolecular
organic
framework
(SOF)
in
water
via
host–guest
interactions,
which
exhibits
regulation
of
ROS
and
high
photocatalytic
efficiency.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(47), P. 32161 - 32205
Published: Nov. 18, 2024
Covalent
organic
frameworks
(COFs)
are
created
by
the
condensation
of
molecular
building
blocks
and
nodes
to
form
two-dimensional
(2D)
or
three-dimensional
(3D)
crystalline
frameworks.
The
diversity
with
different
properties
functionalities
large
number
possible
framework
topologies
open
a
vast
space
well-defined
porous
architectures.
Besides
more
classical
applications
materials
such
as
absorption,
separation,
catalytic
conversions,
interest
in
optoelectronic
COFs
has
recently
increased
considerably.
electronic
both
their
linkage
chemistry
can
be
controlled
tune
photon
absorption
emission,
create
excitons
charge
carriers,
use
these
carriers
photocatalysis,
luminescence,
chemical
sensing,
photovoltaics.
In
this
Perspective,
we
will
discuss
relationship
between
structural
features
properties,
starting
connectivity,
layer
stacking
2D
COFs,
control
over
defects
morphology
including
thin
film
synthesis,
exploring
theoretical
modeling
structural,
electronic,
dynamic
discussing
recent
intriguing
focus
on
photocatalysis
photoelectrochemistry.
We
conclude
some
remarks
about
present
challenges
future
prospects
powerful
architectural
paradigm.
