Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
In
the
face
of
escalating
antibiotic
resistance
crisis,
world
is
embroiled
in
a
silent
“antibacterial
war”.
Scientists
are
actively
searching
for
innovative
antibacterial
materials
that
can
be
used
as
effective
weapons
against
bacterial
infections.
As
promising
new
crystalline
porous
polymer
materials,
covalent
organic
frameworks
(COFs)
gradually
revealing
their
vast
potential
applications.
This
study
investigates
classification
COF‐based
agents,
provides
comprehensive
overview
applications
and
research
advancements,
explores
strategies
employed
by
COF
materials.
Furthermore,
challenges
outlined
lie
ahead
future
application
agents
insights
into
prospects
within
field
offered.
Through
these
efforts,
aim
to
accelerate
advancements
COFs
manufacturing
technology,
promote
innovation
applications,
contribute
public
health.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Cryosurgery
represents
a
transformative
approach
in
the
treatment
of
resistant
tumors,
utilizing
extreme
cold
to
selectively
ablate
malignant
tissue.
However,
clinical
success
this
technique
is
constrained
by
limited
ability
current
imaging
techniques
differentiate
effectively
between
cancerous
and
healthy
tissues
with
high
spatial
resolution.
To
overcome
challenge,
we
present
nanoscale
Covalent
Organic
Framework,
nTG-DFP-COF,
specifically
designed
enhance
fluorescence-guided
cryo-imaging.
This
framework
exhibits
unique
temperature-dependent
luminescence,
that
results
enhanced
fluorescence
emission
under
cryogenic
conditions,
enabling
precise
tissue
differentiation
during
surgical
procedures.
Engineered
for
biocompatibility
water
dispersibility,
nTG-DFP-COF
demonstrates
minimal
cytotoxicity
exceptional
specificity
toward
cancer
cells.
Comprehensive
vitro,
vivo,
ex
vivo
evaluations
confirm
its
structural
stability
functional
efficacy
conditions.
innovation
not
only
enhances
precision
safety
cryosurgical
procedures
but
also
advances
integration
diagnostic
therapeutic
functionalities
into
unified
platform.
By
substantially
improving
tumor
targeting
accuracy,
use
will
reduce
need
repeat
surgeries,
facilitate
faster
recovery,
minimize
healthcare
costs,
thus
setting
new
standard
oncologic
intervention.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
In
situ
personalized
tumor
vaccines
are
produced
directly
at
the
primary
site
by
killing
cancer
cells
and
stimulating
immune
cells,
they
effective
against
individuals
bypass
complexity
high
cost
of
in
vitro
vaccine
production.
However,
their
clinical
application
is
hindered
insufficient
efficiency
inducing
immunogenic
cell
death
(ICD)
systemic
inflammation
caused
adjuvants.
Here,
constructed
for
melanoma
immunotherapy
based
on
bioorthogonal
catalytic
microneedles,
which
enable
release
prodrugs
sites
mediate
strong
ICD
an
enhanced
response
while
avoiding
storms
toxic
side
effects.
By
incorporating
TiO2
nanosheets
supported
Pd
into
swellable
microneedles
to
catalyze
depropargylation
reaction
doxorubicin
(DOX)
prodrug
imiquimod
(IMQ)
situ.
The
activated
DOX
subcutaneous
induced
released
tumor-associated
antigens.
Concurrently,
IMQ
acts
as
a
Toll-like
receptor
(TLR7)
agonist,
enhancing
anti-tumor
response.
vivo
experiments
demonstrate
that
this
achieves
≈97%
inhibition
tumors
effectively
inhibits
untreated
distant
(≈94%
inhibition)
lung
metastasis
(≈92%
inhibition).
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Covalent
organic
framework
(COF)-derived
carbon
materials
seamlessly
inherit
the
periodic
porous
architecture
and
high
specific
surface
area
of
their
precursors,
while
simultaneously
enabling
confinement
nanoparticles
in
designated
regions.
This
unique
feature
mitigates
agglomeration,
enhances
intrinsic
properties,
imparts
novel
functionalities
to
resulting
materials.
Consequently,
COF-derived
have
garnered
significant
attention
across
diverse
fields,
including
energy,
environmental
remediation,
biomedical
applications.
Despite
this
burgeoning
interest,
a
comprehensive
review
encompassing
synthesis,
classification,
multifaceted
applications
these
remains
scarce.
In
context,
state-of-the-art
advancements
are
reviewed
systematically
here.
It
categorizes
materials,
delineates
primary
synthesis
strategies,
highlights
versatile
catalysis,
electrochemical
energy
storage,
water
treatment,
sensing,
cancer
therapy.
Lastly,
fresh
insights
into
challenges
future
prospects
paving
way
for
expanded
exploration
utilization
offered
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 1, 2025
The
creation
and
development
of
classical
multifunctional
nanomaterials
are
crucial
for
the
advancement
nanotherapeutic
treatments
tumors.
Currently,
metal–organic
frameworks
(MOFs)
modified
with
polydopamine
(PDA)
at
forefront
nanomedicine
research,
particularly
in
tumor
diagnostics
therapy,
owing
to
their
exceptional
biocompatibility,
expansive
specific
surface
area,
multifaceted
functionalities,
superior
photothermal
properties,
which
led
significant
advancements
anti-tumor
research.
Consequently,
a
range
anti-cancer
strategies
has
been
devised
by
leveraging
capabilities
MOFs,
including
intelligent
drug
delivery
systems,
photodynamic
tailored
microenvironment.
In
order
gain
deeper
insight
into
role
MOFs@PDA
cancer
diagnosis
treatment,
it
is
essential
conduct
comprehensive
review
existing
research
outcomes
promptly
analyze
challenges
associated
biological
applications.
This
will
provide
valuable
perspectives
on
potential
clinical
settings.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
Abstract
Depression
is
a
significant
global
health
concern
with
limited
effective
treatment
strategies
to
date.
Elevated
homocysteine
identified
as
critical
factor
contributing
the
severity
of
depression
by
aggravating
neuroinflammation.
Herein,
this
study
develops
diverse
array
homocysteine‐stimulated
responsive
covalent
organic
frameworks
(COFs)
novel
therapeutic
agents.
Using
Schiff‐base
condensation
reactions
between
cystamine/selenocystamine
and
various
C
2
‐
3
‐symmetric
aryl
aldehydes,
it
successfully
synthesized
library
20
COFs.
The
sensitivity
specificity
resultant
COFs
for
clearance
are
validated
using
serum
samples
from
patients
mouse
model.
Non‐targeted
metabolomics
transcriptomics
analyses
revealed
that
these
not
only
exogenously
directly
scavenge
but
also
synergistically
enhance
transsulfuration
pathway
within
endogenous
metabolic
cycle
efficient
clearance.
Furthermore,
mitigated
neuroinflammation
inhibiting
inflammatory
responses,
scavenging
reactive
oxygen
species,
modulating
neuronal
microglial
activity.
They
activated
neuroactive
ligand‐receptor
signaling
pathways
preserved
mitochondrial
function,
thereby
maintaining
oxidative
phosphorylation.
Collectively,
mechanisms
resulted
in
improvements
anxiety
depressive
behaviors
mice.
This
pioneers
application
homocysteine‐responsive
treatment,
opening
up
tremendous
opportunities
biomedical
applications
