Artificial Polymerizations in Living Organisms for Biomedical Applications DOI
Yun Chen,

Brynne Shu Ni Tan,

Yu Cheng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract Within living organisms, numerous nanomachines are constantly involved in complex polymerization processes, generating a diverse array of biomacromolecules for maintaining biological activities. Transporting artificial polymerizations from lab settings into contexts has expanded opportunities understanding and managing events, creating novel cellular compartments, introducing new functionalities. This review summarizes the recent advancements polymerizations, including those responding to external stimuli, internal environmental factors, that polymerize spontaneously. More importantly, cutting‐edge biomedical application scenarios polymerization, notably safeguarding cells, modulating improving diagnostic performance, facilitating therapeutic efficacy highlighted. Finally, this outlines key challenges technological obstacles remain as well offers insights potential directions advancing their practical applications clinical trials.

Language: Английский

Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply DOI Creative Commons
Chenghao Pan,

Xiuxian Jiang,

Junchao Wei

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 20, 2025

Nutrient competition with indigenous microbes or pathogens presents a significant challenge for oral probiotic efficacy. To address this issue, we develop an ameba-inspired food-carrying strategy (AIFS) by prebinding ginger-derived exosome-like nanoparticles (GELNs) onto probiotics as food depots. AIFS enables to efficiently and exclusively consume GELNs in situ, even the presence of competing bacteria. This results up 21 times higher uptake efficiency compared unengineered probiotics, dramatically accelerating proliferation. Meanwhile, potentiates probiotics' resistance multiple GI stressors. In murine model colitis, can improve abundance inhibit pathogens, maintaining intestinal flora homeostasis. Additionally, it upregulate anti-inflammatory IL-10, reduce proinflammatory IL-1β, repair damaged mucus. Thereby, displays potently elevated prophylactic therapeutic efficacy colitis mice. work provides method microbial engineering, broad implications microbiotherapy gut health.

Language: Английский

Citations

0
Engineered Hollow Nanocomplex Combining Photothermal and Antioxidant Strategies for Targeted Tregs Depletion and Potent Immune Activation in Tumor Immunotherapy DOI Open Access
Qi Sun, Mengling Liu,

Hetian Ren

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract In the tumor immunosuppressive microenvironment (TIME), regulatory T cells (Tregs) critically suppress anticancer immunity, characterized by high expression of glucocorticoid‐induced TNF receptor (GITR) and sensitivity to reactive oxygen species (ROS). This study develops a near‐infrared (NIR)‐responsive hollow nanocomplex (HPDA‐OPC/DTA‐1) using polydopamine nanoparticles (HPDA), endowed with thermogenic antioxidative properties, specifically targeting Tregs activate antitumor immunity. The GITR agonist DTA‐1, combined antioxidant oligomeric proanthocyanidins (OPC) deplete Tregs. However, depletion alone may not sufficiently trigger robust immune responses. HPDA nanocarrier enhances capacities, supporting photothermal immunotherapy. HPDA‐OPC/DTA‐1 demonstrates NIR responsiveness for both therapy (PTT) OPC release, while facilitating via DTA‐1 reducing ROS levels, thereby reviving Notably, intratumoral CD4 + CD25 FOXP3 exhibited 4.08‐fold reduction alongside 49.11‐fold increase in CD8 cells/Tregs relative controls. Enhanced dendritic (DCs) maturation immunogenic cell death (ICD) induction further demonstrate that alleviates immunosuppression activates Ultimately, observed inhibitory effect (tumor volume: 6.75‐fold versus control) an over 80% survival rate highlight therapeutic potential combining targeting, strategy, immunotherapy effective cancer treatment.

Language: Английский

Citations

0
Hydrogel-Based Bioactive Synthetic Skin Stimulates Regenerative Gas Signaling and Eliminates Interfacial Pathogens to Promote Burn Wound Healing DOI
Haifeng Zhang, Wei Zhou, Haibing Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Skin burn wounds (SBWs) are common clinical injuries due to excessive exposure factors including heat, radiation, chemical agents, etc. However, the efficient healing of SBWs is still challenging persistent inflammation and high risk local infection. To meet these challenges, we report a hydrogel-based bioactive synthetic skin (HBSS) from biocompatible components as dressing materials for wound treatment, which mediated localized H2S release stimulate tissue regeneration while preventing bacterial infection inflammation. Here, donor (N-(benzoyl mercapto) benzamide) was first coassembled with thioketal (TK)-ligated dopamine dimer form nanoscale assemblies (DDNs), were then integrated into Schiff base-cross-linked hyaluronic acid-carboxymethyl chitosan hydrogels. The elevated acidity in would trigger hydrogel degradation DDNs, further activated by ROS-induced cleavage TK linkers gas attenuating ROS stress self-immolative manner, thus promoting angiogenesis through activating AMPK RAS-MAPK-AP1 prohealing pathways, enabling M1-to-M2 macrophage reprogramming ERK1/2 NRF2 signaling. Meanwhile, network could inhibit colonization at site prevent These merits acted cooperative manner enable accelerated robust healing, offering an approach treatment clinic.

Language: Английский

Citations

0
In situ polymer synthesis within living systems for cancer immunotherapy DOI
Yun Chen, Wei Zhu

Published: April 1, 2025

Language: Английский

Citations

0
Hydrogen bond-induced elastic polyzwitterion electrolytes constructed by mussel-inspired autopolymerization for zinc-ion battery DOI
Shi Wang, Xinyi Wu, Chao Liu

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 3438 - 3449

Published: Aug. 16, 2024

Language: Английский

Citations

3
Trojan Horse Strategy for Wireless Electrical Stimulation-Induced Zn2+ Release to Regulate Neural Stem Cell Differentiation for Spinal Cord Injury Repair DOI

Shuwei Han,

Dapeng Zhang,

Yanbing Kao

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(47), P. 32517 - 32533

Published: Nov. 11, 2024

Due to the uncertain differentiation of neural stem cells (NSCs), replenishing lost neurons by endogenous repair spinal cord injury (SCI) remains challenging. The electrical stimulation-induced drug release is a promising approach for localized and controlled drugs regulate NSCs into neurons. Here, we developed Zn-PDA@BT nanoparticles acted as Trojan Horse enter through endocytosis Zn

Language: Английский

Citations

3
Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme DOI

Changyu Cao,

Da Bao Zha,

Chencheng Sun

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 398 - 407

Published: Dec. 14, 2024

Language: Английский

Citations

3
Administration sequence- and formation-dependent vaccination using acid-degradable polymeric nanoparticles with high antigen encapsulation capability DOI

Yeon Su Choi,

Jiin Felgner,

Sharon Jan

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(27), P. 6577 - 6586

Published: Jan. 1, 2024

Acid-degradable polymeric nanoparticles with a high capability of GFP encapsulation demonstrate efficient antibody production in combination booster injection free antigens.

Language: Английский

Citations

2
Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications DOI Creative Commons
Xia Lin, Rong Jiao, Haowen Cui

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 12, 2024

With the comprehensive understanding of microorganisms and rapid advances physiochemical engineering bioengineering technologies, scientists are advancing rationally-engineered bacteria as emerging drugs for treating various diseases in clinical disease management. Engineered specifically refer to advanced or genetic technologies combination with cutting edge nanotechnology physical which have been validated play significant roles lysing tumors, regulating immunity, influencing metabolic pathways, etc. However, there has no specific reviews that concurrently cover physiochemically- genetically-engineered their derivatives yet, let alone distinctive design principles functions applications. Herein, applications physiochemically bacteria, classify discuss breakthroughs an emphasis on methods objective different uses beyond cancer is described. The combined strategies developing vivo biotherapeutic agents based these bacterial derivatives, elucidated how they repress other also underlined. Additionally, challenges faced by translation future development directions discussed. This review expected provide overall impression enlighten more researchers.

Language: Английский

Citations

2
Ultrasound-Induced In Situ Dopamine Polymerization and Deep Mucosal Penetration for Intraluminal Drug Administration DOI
Yang Li, Qianqian Zhang, Yuzhu Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20611 - 20623

Published: July 26, 2024

Prolonging the residence time of drugs in lumen and propelling them into deep lesions are highly desired for intraluminal drug administration. However, rapid efflux caused by dynamic contents limits sustained concentrations, causing poor pharmaceutical absorption reduced efficacy. Here, we combined theory experiments to demonstrate a distinctive delivery strategy using clinically available medical ultrasound technology. Through ultrasound-induced vivo dopamine polymerization rapidly high-energy shock waves, resultant formulations can tolerate variable environment penetrate mucosa. As result, this ultrasound-mediated situ adhesion self-propelled technique signal secure universal coating functional layers vivo. Theoretically, is applicable any hollow tissue, where accessible.

Language: Английский

Citations

2