Catalysts,
Journal Year:
2024,
Volume and Issue:
14(4), P. 219 - 219
Published: March 22, 2024
In
the
past
few
decades,
N-heterocyclic
carbenes
(NHCs)
have
opened
new
field
of
organocatalysis
in
synthetic
organic
chemistry.
This
review
highlights
dramatic
progress
NHC-catalyzed
C–O
bond
formation
based
on
activation
aldehyde
C(sp2)–H
bonds.
The
oxidative
and
redox
transformations
for
synthesis
various
molecules
with
structural
diversity
complexity
are
summarized.
Furthermore,
methods
strategies
NHC
catalysis
emerging
continuously;
thus,
cooperative
Brønsted
acid,
hydrogen-bonding
catalyst,
transition-metal
photocatalyst
also
described.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(13), P. 2898 - 2918
Published: May 18, 2024
Abstract
Converting
any
desired
C−H
bond
to
the
intended
C−Z
in
a
given
organic
molecule
could
be
final
peak
of
functionalization
methodology.
Among
three
types
bonds,
ubiquitous
C(
sp
3
)−H
has
gained
particular
attention,
especially
last
two
decades.
There
are
different
ways
transform
bonds
into
bonds.
The
use
chlorine
radicals
is
one
these
methods
with
promising
future.
literature
review
shows
that
sources
have
been
used
for
chlorine,
including
chloride
ions
(HCl
or
salts),
coordinated
chlorides
(transition
metal
complexes),
and
(organochlorine
compounds).
However,
HCl
FeCl
most
attention
among
sources.
major
convert
from
radicals:
1)
oxidation
hydrogen
salts,
2)
photolysis
chloride,
3)
transition
insertion
C−Cl
This
summarizes
published
research
papers
on
functionalization.
Therefore,
chlorination
reactions
which
do
not
play
direct
role
cleavage
within
scope
this
review.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 20, 2024
Photocatalysis
holds
a
pivotal
position
in
modern
organic
synthesis,
capable
of
inducing
novel
reactivities
under
mild
and
environmentally
friendly
reaction
conditions.
However,
the
merger
photocatalysis
transition-metal-catalyzed
asymmetric
C-H
activation
as
an
efficient
sustainable
method
for
construction
chiral
molecules
remains
elusive
challenging.
Herein,
we
develop
cobalt-catalyzed
enantioselective
enabled
by
visible-light
photoredox
catalysis,
providing
synergistic
catalytic
strategy
dearomatization
indoles
with
high
levels
enantioselectivity
(96
%
to
>99
ee).
Mechanistic
studies
indicate
that
excited
photocatalyst
was
quenched
divalent
cobalt
species
presence
Salox
ligand,
leading
formation
catalytically
active
Co(III)
complex.
Moreover,
stoichiometric
reactions
cobaltacycle
intermediate
indole
suggest
irradiation
visible
light
also
play
critical
role
step.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 14, 2024
Abstract
The
direct
alkenylation
with
simple
alkenes
stands
out
as
the
most
ideal
yet
challenging
strategy
for
obtaining
high-valued
desaturated
alkanes.
Here
we
present
a
asymmetric
dehydrogenative
α
-C(sp
3
)-H
of
carbonyls
based
on
synergistic
photoredox-cobalt-chiral
primary
amine
catalysis
under
visible
light.
ternary
catalytic
system
enables
coupling
β
-keto-carbonyls
and
through
cooperative
radical
addition-dehydrogenation
process
involving
chiral
-imino
Co(II)-metalloradical
intermediate.
A
H-transfer
nitrobenzene
is
engaged
to
quench
in
situ
generated
cobalt
hydride
species,
ensuring
chemoselective
good
yields
high
enantioselectivities.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
paper
reviews
progress
in
the
photochemical/electrochemical
construction
of
heterocyclic
compounds
using
CO
2
,
differentiating
between
various
reaction
types
and
elucidating
their
underlying
mechanisms
as
well
potential
applications.
Direct
enantioselective
functionalization
of
C(sp3)–H
bonds
in
organic
molecules
could
fundamentally
transform
the
synthesis
chiral
molecules.
In
particular,
oxidation
these
would
dramatically
change
production
alcohols
and
esters,
which
are
prevalent
natural
products,
pharmaceuticals,
fine
chemicals.
Remarkable
advances
have
been
made
construction
carbon-carbon
carbon-nitrogen
through
bond
functionalization.
However,
direct
formation
carbon-oxygen
from
remains
a
considerable
challenge.
We
herein
report
highly
oxidative
coupling
with
carboxylic
acids
using
molecular
copper
catalyst
activated
by
blue
light.
The
method
applies
to
allylic
propargyl
C–H
more
importantly
employs
various
as
oxygenating
agents.
By
this
method,
we
successfully
synthesized
range
esters
directly
readily
available
alkenes
alkynes,
greatly
simplifying
related
alcohols.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 25, 2024
Due
to
the
high
reactivity
and
versatility
of
benzenesulfonothioates,
significant
advancements
have
been
made
in
constructing
C-S
bonds.
However,
there
are
certain
limitations
synthesis
S-thiosulfonates
SS-thiosulfonates,
especially
when
dealing
with
substantial
steric
hindrance,
which
poses
a
challenge.
Herein,
we
present
an
innovative
approach
for
assembling
unsymmetric
SS-thiosulfonates
through
integration
dual
copper/photoredox
catalysis.
Moreover,
also
realized
one-pot
strategy
by
directly
using
carboxylic
acids
as
raw
materials
in-situ
activation
them
access
without
further
purification
presynthesis
NHPI
esters.
The
envisaged
utilization
these
reagents
poised
pioneer
pathway
fabricating
versatile
spectrum
mono-,
di-,
polysulfide
compounds.
Furthermore,
they
introduce
class
potent
sulfenylating
reagents,
empowering
intricate
unsymmetrical
disulfides
that
were
previously
challenging
access.
conventional
method
synthesizing
thioether
compounds
typically
relies
on
thiol,
disulfide,
sulfinyl
halide
initial
substances,
suffering
from
strong
odors,
limited
availability,
issues.
Here,
authors
catalysis
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(75), P. 10378 - 10381
Published: Jan. 1, 2024
Here
we
report
a
visible-light
facilitated
radical
addition
strategy
for
the
preparation
of
various
natural
or
unnatural
α-amino
acids
from
readily
available
glycine
derivatives
and
alkenes.
A
key
aspect
in
achieving
this
side
carbon
chain
introduction
reaction,
while
circumventing
well-documented
cyclization
pathway,
was
employment
radical-polar
crossover
under
redox
neutral
conditions.
Bulletin of the Korean Chemical Society,
Journal Year:
2024,
Volume and Issue:
45(9), P. 738 - 758
Published: Sept. 1, 2024
Abstract
Halogenation
is
one
of
the
most
important
transformations
in
organic
synthesis.
Halogenated
compounds
are
employed
many
reactions
to
prepare
useful
molecules.
Many
methods
have
been
developed
introduce
halogens
into
different
compounds.
Visible
light‐mediated
efficient,
low‐toxic,
and
mild‐condition
applied
for
various
chemistry
transformations.
Remarkably,
there
has
an
increasing
development
application
visible
light‐induced
halogenation
recent
years.
Herein,
we
present
a
comprehensive
summary
including
chlorination,
bromination,
iodination
under
light
irradiation
since
2020.
