Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110808 - 110808
Published: Dec. 1, 2024
Language: Английский
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(12), P. 8500 - 8507
Published: March 14, 2024
The selective transmembrane permeation of sodium ions achieved by biomimetic chemistry shows great potential to solve the problem ion transport blockade in diseases, but its implementation faces enormous difficulties. Herein, we design and synthesize a series helically folded nanopores employing quinoline-oxadiazole structural sequence finely replicate pentahydrate structure ions. Surprisingly, these are capable achieving with selectivity at level natural channels, as observed rationally designed (M1–M5) Na+/K+ ratio up 20.4. Moreover, slight variations nanopore structures can switch modes between channel carrier. We found that, compared carrier mode, mode not only transports faster also has higher during conduction, clearly illustrating that trade-off phenomenon activity does occur two At same time, spatial position numbers coordination sites crucial for nanopores. M1 reported this work is totally superior commercial Na+ ETH2120, especially terms selectivity, thus being potentially practical Our study provides new paradigm on rational sodium-specific synthetic nanopores, which will open possibility application artificial biomedicine disease treatment.
Language: Английский
Citations
9
Analytical Chemistry, Journal Year: 2025, Volume and Issue: 97(1), P. 613 - 621
Published: Jan. 2, 2025
The research of chiral separation technology is great significance for understanding the origin life and promoting application molecules. Herein, anionic pillar[6]arene cationic were designed synthesized, a membrane was constructed by layer-by-layer assembly through electrostatic interactions. transport rates l-Ala d-Ala in this channel 14.33 1.86 μM cm–2 h–1, respectively, rate 7.7 times that d-Ala. In experiment Ala racemate, ee value permeate after single 62%, indicating has certain ability. effects method, number layers, driving force on effect further studied, selective mechanism explored host–guest interaction at molecular level theoretical simulation. This strategy provides new template expanding pillar[n]arenes field separation.
Language: Английский
Citations
1
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 22, 2024
The importance of molecular docking in drug discovery lies the precise recognition between potential compounds and their target receptors, which is generally based on computational method. However, it will become quite interesting if rigid cavity structure supramolecular macrocycles can precisely recognize a series guests with specific fragments by mimicking through co-crystallization experiments. Herein, we report phenylphosphine oxide-bridged aromatic macrocycle, F[3]A1-[P(O)Ph]
Language: Английский
Citations
7
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: May 11, 2025
Transmembrane selective transport of metabolites controls essential biological functions. During the last two decades, artificial channels have been developed and cyclic peptides emerged as ideal platforms for efficient ion, sugar, nucleic acid channel translocation. Despite these tremendous developments, eluded water transport. Herein, we report formation narrow β-helical tubules with diameters ranging from 2.80 to 3.25 Å that selectively control translocation, akin natural aquaporin channels. The tubular assemblies resulted metal-driven folding assembly minimal heterochiral metal-binding 3-pyridyl-terminated peptides. bent ultrashort peptide ligand coordinates Ag+ metal ions in a head-to-tail manner, which undergoes subsequent polymerization into structure stabilized by interstrand hydrogen bonds (H-bonds) between β-strands π-π staking interactions terminal pyridyl moieties. Furthermore, sequence engineering ion coordination tailored enabled distinct synthetic double β-barrel assemblies, molecules encapsulated hydrophilic core tubes. These water-encapsulated tubes were further explored lipid bilayers. Our findings suggest such achieve single-channel permeability 106 molecules/second/channel, is within 1-2 orders magnitude lower than aquaporins, rather good ability sterically reject prevent proton present significant potential membranes purification separation sciences.
Language: Английский
Citations
0
ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(4), P. 1080 - 1096
Published: March 28, 2024
The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among challenges posed, biofilms stand out due to their formidable resistance conventional antibiotics. This review delves burgeoning potential pillar[n]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. is structured two main sections, each dedicated exploring distinct facets pillar[n]arene applications. first section scrutinizes functionalized pillar[n]arenes with particular emphasis on cationic derivatives. analysis reveals significant efficacy inhibiting biofilm formation, underscoring pivotal role specific chemical attributes combating microbial communities. second shifts its focus inclusion complexes, elucidating how serve encapsulation platforms for enhances stability antibiotics and enables controlled release, thereby amplifying antibacterial activity. examination complexes provides valuable insights synergy between traditional antibiotics, offering novel avenue overcoming resistance. comprehensive highlights escalating threat infections urgent need innovative strategies counteract biofilms. unique properties both molecules complex hosts, position them candidates quest effective exploration mechanisms opens new avenues research development ongoing battle against biofilm-related challenges.
Language: Английский
Citations
3
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Nov. 15, 2024
Natural channel proteins allow the selective permeation of ions, water or other nutritious entities across bilayer membranes, facilitating various essential physiological functions in living systems. Inspired by nature, chemists endeavor to simulate structural features and transport behaviors through biomimetic strategies. In this review, we start from introducing inherent traits such as their crystal structures, mechanisms. Subsequently, different kind synthetic ion channels including design principles, dynamic regulations therapeutic applications were carefully reviewed. Finally, potential challenges opportunities research field also discussed. It is anticipated that review could provide some inspiring ideas future directions towards construction novel bionic with higher-level properties, practical applications.
Language: Английский
Citations
2
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Sept. 20, 2024
Artificial water channels (AWCs) have been extensively explored to mimic natural proteins, which enables effectively transport while blocking ions. As one of the first AWCs, self-assembled I-quartets (HCx) showcased high water-permselectivity that can be enhanced by improving their distribution and stability within membrane. The use long alkyl chains (n>8) is constrained low solubility aggregation. Herein, we considered cycloalkyl moieties, for increase favoring partition and/ self-assembly behaviors resulting formation effective stable water-channels with increased permeability in bilayer membranes. This class cycloalkyl-ureido-ethyl-imidazole amphiphilic (CxUH) channel could serve as a new reference design artificial channels, it may give rise applications desalination or treatment.
Language: Английский
Citations
1
Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 145, P. 155178 - 155178
Published: July 1, 2024
During the last years diverse Pillar[n]arenes have been intensively used as molecular systems for recognition and synthons self-assembly, toward construction of highly selective supramolecular materials or functional devices. They present an electron-rich cavity, well reactive rims that can be decorated with specific groups, resulting in formation tubular pillar shape architectures. For this reasons pillar[n]arenes are excellent candidates artificial water, ionic, proton, channels through bilayer polymeric membranes membrane separations. This review integrate most recent examples synthetic to elaborate nanodevices water translocation, ion proton rectification useful important application environmental sciences purification medicine.
Language: Английский
Citations
0
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 19, 2024
Nature has ingeniously developed specialized water transporters that effectively reject ions, including protons, while transporting across membranes. These natural channels, known as aquaporins (AQPs), have inspired the creation of Artificial Water Channels (AWCs). However, replicating superfast transport with synthetic molecular structures exclude salts and protons is a challenging task. This endeavor demands coexistence suitable water-binding site selective filter for precise transportation. Here, we present small-molecule hydrazides 1 b-1 d self-assemble into rosette-type nanochannel assembly through intermolecular hydrogen bonding π-π stacking interactions, selectively molecules lipid bilayer The experimental analysis demonstrates notable permeability rates c derivative, enabling approximately 3.18×10
Language: Английский
Citations
0
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 19, 2024
Abstract Nature has ingeniously developed specialized water transporters that effectively reject ions, including protons, while transporting across membranes. These natural channels, known as aquaporins (AQPs), have inspired the creation of Artificial Water Channels (AWCs). However, replicating superfast transport with synthetic molecular structures exclude salts and protons is a challenging task. This endeavor demands coexistence suitable water‐binding site selective filter for precise transportation. Here, we present small‐molecule hydrazides 1 b–1 d self‐assemble into rosette‐type nanochannel assembly through intermolecular hydrogen bonding π‐π stacking interactions, selectively molecules lipid bilayer The experimental analysis demonstrates notable permeability rates c derivative, enabling approximately 3.18×10 8 to traverse channel per second. rate about one order magnitude lower than AQPs. Of particular significance, ensures exclusive passage blocking protons. MD simulation studies confirmed stability properties inside membranes at ambient conditions.
Language: Английский
Citations
0