Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post-PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo-triggered
porphyrin
polyelectrolyte
nanoassembling
(photo-triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal-ligand
coordination.
The
polyelectrolyte-based
PPN
exhibits
good
biocompatibility,
bestows
unique
"confining
isolated"
inner
microenvironment
fully
overcoming
π-π
stacking
porphyrins
with
significant
efficiency
(123-fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed-form,
could
use
light
as
specific
trigger
modulate
closed-
open-form,
manipulate
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 15, 2024
Abstract
High‐performance
theranostic
systems
are
of
paramount
importance
for
achieving
precise
image‐guided
cancer
immunotherapy.
Here,
a
novel
nanoplatform
is
presented
that
integrates
aggregation‐induced
emission
luminogen
(AIEgen)
with
prussian
blue
(PB)
nanocatalyzer
robust
The
AIEgen
dimethylamine
substitution
demonstrates
compelling
near‐infrared
(NIR)
light‐induced
photothermal
conversion
and
photodynamic
therapy
(PDT)
capabilities.
By
incorporating
into
porous
PBNPs,
further
enveloped
within
M1
macrophage
membrane,
tumor‐specific
nanoagent
constructed.
This
strategic
integration
effectively
constrains
the
molecular
motion
AIEgen,
leading
to
amplified
NIR‐II
fluorescence
brightness
PDT
attributes.
Moreover,
PBNPs
can
catalyze
tumor‐overexpressed
H
2
O
generate
oxygen
boost
efficacy,
PB's
NIR
absorption
also
intensifies
photoacoustic
imaging
effect.
provides
comprehensive
information
photoimmunotherapy
in
orthotopic
breast
cancer‐bearing
mice.
Leveraging
its
potent
immunogenic
cell
death
effect,
not
only
significantly
inhibits
growth,
but
generates
whole‐cell
therapeutic
vaccine
protect
mice
from
tumor
rechallenge.
In
highly
malignant
post‐surgery
models,
enables
both
accurate
identification
residual
tumors
efficient
inhibition
postoperative
recurrence
pulmonary
metastasis.
study
will
offer
valuable
insights
creating
efficacious
multifaceted
protocols.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(7), P. 4620 - 4631
Published: Feb. 8, 2024
Pancreatic
cancer
is
highly
lethal.
New
diagnostic
and
treatment
modalities
are
desperately
needed.
We
report
here
that
an
expanded
porphyrin,
cyclo[8]pyrrole
(CP),
with
a
high
extinction
coefficient
(89.16
L/g·cm)
within
the
second
near-infrared
window
(NIR-II),
may
be
formulated
αvβ3-specific
targeting
peptide,
cyclic-Arg-Gly-Asp
(cRGD),
to
form
cRGD-CP
nanoparticles
(cRGD-CPNPs)
promising
NIR-II
photothermal
(PT)
therapeutic
photoacoustic
(PA)
imaging
properties.
Studies
ring-array
PA
tomography
system,
coupled
analysis
of
control
lacking
element
(CPNPs),
revealed
cRGD
conjugation
promoted
delivery
NPs
through
abnormal
vessels
around
tumor
solid
core.
This
proved
true
in
both
subcutaneous
orthotopic
pancreatic
mice
models,
as
confirmed
by
immunofluorescent
studies.
In
combination
laser
photoirradiation,
cRGD-CPNPs
provided
near-baseline
growth
inhibition
PTT
vitro
vivo.
Notably,
present
photoirradiation
was
found
inhibit
intra-abdominal
metastases
mouse
model.
The
also
displayed
good
biosafety
profiles,
inferred
from
tomography,
blood
analyses,
H&E
staining.
They
thus
appear
for
use
combined
PT
cancer.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(3), P. 1088 - 1112
Published: Jan. 29, 2024
Cancer
immunotherapy,
aimed
at
reinvigorating
the
immune
system
to
induce
a
lasting
anticancer
response,
has
emerged
as
promising
approach
for
counteracting
evasive
tactics
of
cancer
cells.
This
study
delves
into
innovative
realm
stimuli-responsive
polymeric
nanomedicines
in
context
immunotherapy.
By
capitalizing
on
intricate
landscape
tumor
microenvironment
(TME),
which
orchestrates
suppression
and
progression,
offer
tailored
strategy
enhance
therapeutic
interventions.
The
aberrant
features
TME,
include
factors
such
low
pH,
inflammation,
oxidative
stress,
enzyme
overexpression,
serve
triggers
intelligent
delivery
systems
facilitated
by
functional
polymers.
dynamic
potential
overcome
challenges
faced
traditional
nanoparticle-based
immunotherapy
techniques,
presenting
platform
precisely
optimize
drug
within
locale.
As
synergistic
interaction
between
TME
unfolds,
novel
horizon
emerges
advance
efficacy
while
mitigating
its
associated
limitations.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(12), P. 8547 - 8556
Published: March 18, 2024
Photocatalysis
has
found
increasing
applications
in
biological
systems,
for
example,
localized
prodrug
activation;
however,
high-energy
light
is
usually
required
without
giving
sufficient
efficiency
and
target
selectivity.
In
this
work,
we
report
that
ion
pairing
between
photocatalysts
prodrugs
can
significantly
improve
the
photoactivation
enable
tumor-targeted
activation
by
red
light.
This
exemplified
a
gold-based
(1d)
functionalized
with
morpholine
moiety.
Such
modification
causes
1d
to
hydrolyze
aqueous
solution,
forming
cationic
species
tightly
interacts
anionic
photosensitizers
including
Eosin
Y
(EY)
Rose
Bengal
(RB),
along
significant
bathochromic
shift
of
absorption
tailing
far-red
region.
As
result,
high
EY
or
RB
under
low-energy
was
found,
leading
an
effective
release
active
gold
living
cells,
as
monitored
gold-specific
biosensor
(GolS-mCherry).
Importantly,
moiety,
pKa
∼6.9,
brings
highly
pH-sensitive
preferential
ionic
interaction
slightly
acidic
condition
over
normal
physiological
pH,
enabling
irradiation
vitro
vivo.
Since
similar
change
other
morpholine/amine-containing
clinic
drugs,
photocages,
precursors
reactive
labeling
intermediates,
it
believed
ion-pairing
strategy
could
be
extended
targeted
different
mapping
microenvironment
Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
The
development
of
stable
organic
dye
radicals
that
exhibit
intense
and
redox-switchable
absorption
in
the
short-wavelength
infrared
(SWIR)
region
is
highly
desirable
but
remains
a
significant
challenge.
Herein,
we
present
two
neutral
nickel(II)
radical
complexes
tetradentate-type
azadipyrromethene
(ADP),
which
demonstrate
exceptional
stability
under
aerobic
conditions
high
photostability.
nature
stable,
newly
synthesized
[NiII(ADP.)]
was
verified
through
electron
paramagnetic
resonance
spectroscopy,
displayed
predominant
character
with
at
g
=
2.003.
These
SWIR
absorptions
maximum
wavelength
(λmax)
around
1260
nm.
can
be
readily
oxidized
to
corresponding
cations
or
reduced
less
anions,
all
maintain
characteristics.
electronic
configuration,
redox
characteristics,
spectra
developed
systems
were
systematically
investigated
supported
by
theoretical
calculations,
indicating
spin
density
delocalized
across
tetradentate
ADP
core
nickel
atom.
Furthermore,
exhibited
photothermal
conversion
efficiency
60.1%
irradiation
1064
nm
laser,
highlighting
its
potential
for
applications
therapy.
