Precisely Prepared Hierarchical Micelles of Polyfluorene‐block‐Polythiophene‐block‐Poly(phenyl isocyanide) via Crystallization‐Driven Self‐Assembly DOI
Y. Pan,

Chen-Chen Ye,

Silin Huang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract The precise preparation of hierarchical micelles is a fundamental challenge in modern materials science and chemistry. Herein, poly(di‐n‐hexylfluorene)‐ block ‐poly(3‐tetraethylene glycol thiophene) (poly( 1 m ‐ b 2 n )) diblock copolymers polyfluorene‐ ‐polythiophene‐ ‐poly(phenyl isocyanide) triblock were synthesized using one‐pot process via the sequential addition corresponding monomers Ni(II) complex as single catalyst for living/controlled polymerization. crystallization‐driven self‐assembly amphiphilic conjugated poly( ) led to formation nanofibers with controlled lengths narrow dispersity. exhibited white, yellow, red emissions different states. By uniform seeds, introducing polymer unimer seed growth process, adjusting structure poly(phenyl polarity solvent, A−B−A micelles, multiarm branched raft prepared.

Language: Английский

Artificial Phages with Biocatalytic Spikes for Synergistically Eradicating Antibiotic‐Resistant Biofilms DOI
Sutong Xiao, Lan Xie, Yang Gao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 5, 2024

Antibiotic-resistant pathogens have become a global public health crisis, especially biofilm-induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)-adaptive therapeutic strategies are urgently demanded to combat antibiotic-resistant biofilms. Here, inspired by the fascinating biological structures functions of phages, de novo design spiky Ir@Co

Language: Английский

Citations

18
Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles DOI Creative Commons
Jie Zhang, Yi Chen, Guijun Li

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract L1 0 -FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of patterns with hyperfine bit islands is still challenging, especially target miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors solution-processable patterning subsequent generation demanding FePt dots by situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate predefined cells precisely, then intrinsic self-assembly phase-separated further drove formation accurate islands. Benefiting from synergistic effect top-down lithographic approach bottom-up self-assembly, customizable could be achieved large-scale mass targeted areas, high-density isolated also accurately aligned along patterned features after self-assembly. This reliable strategy would provide good avenue precisely construct data storage devices.

Language: Английский

Citations

1
Biocompatible two-dimensional platelets with tunable sizes from polycarbonate-based block copolymers DOI Creative Commons
Chuanqi Zhao, Hannah Schnicke, J. Diego Garcia-Hernandez

et al.

Polymer Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Controlled living crystallization driven self-assembly (CDSA) of poly(dimethyltrimethylene carbonate)- b -poly(ethylene glycol) (PDTC- -PEG) yields uniform two-dimensional (2D) platelets with excellent biocompatibility.

Language: Английский

Citations

1
Nanozyme Cascade Self-Powered H2O2 Strategy for Chemiluminescence Array Sensor to Monitor and Deactivate Multiple Bacteria DOI
Feng Shi,

Haibing Zhu,

Guiling Li

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Early warning and deactivation of multiple bacteria are highly desirable to prevent pathogen-responsible bacterial infectious illnesses. Here, we developed a nanozyme cascade self-powered H2O2 strategy for chemiluminescence (CL) array immunosensor enable high-throughput simultaneous monitoring as well their deactivation. Specifically, novel ZIF-67@CoFePBA yolk–shell was synthesized through dissociation re-coordination mechanism, exhibiting significantly enhanced peroxidase (POD)-like activity due the confinement synergistic effects. utilized immobilize glucose oxidase (GOx) constructing system. can catalyze in-situ produce hydroxyl radicals (·OH), resulting in stable glow-type CL construct immunosensors without exogenous H2O2. The sensor exploited simultaneously detect numerous with wide linear ranges 1.5×10–1.5×107 CFU/mL Staphylococcus aureus 1.5×102–1.5×107 Escherichia coli. Furthermore, generated ·OH destroy internal structure effectively eliminate them. This study provides promising insight into design sensors detection subsequent

Language: Английский

Citations

1
Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection DOI Creative Commons

Xuanxuan Ma,

Na Yang, Ruoyu Mao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 30, 2024

The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited clinical application. Here, self-assembled AMPs composed multiple modules based on the principle associating natural marine peptide N6 with ß-sheet-forming were designed. It is noteworthy that one designed peptides, FFN could self-assemble into nanoparticles at 35.46 µM achieve dynamic transformation from nanofibers in presence bacteria, resulting increase stability trypsin tissues by 1.72-57.5 times compared N6. Additionally, exhibits broad spectrum antibacterial activity against multidrug-resistant (MDR) gram-positive (G

Language: Английский

Citations

6
Bactericidal and Antifouling Coatings with the “Killing–Repelling–Killing” Triple Function Based on Cationic Copolymers with Structure Conversion and Capsaicin Analogue Release DOI
Xiuhua Sun,

Zhiren Guo,

Qingmei Huang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

The capsaicin analogue

Language: Английский

Citations

4
Control over Aspect Ratio and Polymer Spatial Distribution of 2D Platelets via Living Crystallization-Driven Self-Assembly DOI Creative Commons
Tianlai Xia, Laihui Xiao, Kaiwen Sun

et al.

Macromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

Citations

4
Presenting Antimicrobial Peptides on Poly(ethylene glycol): Star-Shaped vs Comb-Like Architectures DOI Creative Commons

Zixian Cui,

Elliot A. Brna,

Matthew A. Crawford

et al.

Macromolecules, Journal Year: 2025, Volume and Issue: 58(4), P. 2073 - 2084

Published: Feb. 5, 2025

Conjugating antimicrobial peptides (AMPs) to nonlinear polymers is a promising strategy overcome the translational challenges of AMPs toward treating infections caused by antibiotic-resistant bacteria. Nonlinear polymers, and therefore conjugates, can be prepared with various architectures (e.g., star-shaped, comb-like, hyperbranched, etc.), however, effects polymer architecture on performance related properties, like size morphology in solution secondary structure, are not yet well-understood. Here, we compare conjugates human chemokine-derived AMP stapled P9 poly(ethylene glycol) (PEG) two major architectures: star-shaped comb-like. At comparable molecular weights compositions (peptide wt %), comb-like afford increased helicity, solubility, activity, proteolytic stability compared analogs. We then leveraged expansive design space prepare different backbone lengths PEG side chain lengths, shorter chains leading potentially less shielding from degradation longest furnishing most potent activity. Both display high zeta potential, indicating that cationic were accessible for electrostatic interactions bacterial membranes. Yet, showed higher fraction unimolecular structures indicative lower propensity supramolecular assembly could encumbering desired AMP-bacteria conjugates. Together, our work shows AMP-polymer outperform analogous while adding flexibility access an range monomer chemistries, distributions, modulate performance-determining properties ultimately furnish effective suite materials as alternatives conventional antibiotics combatting infections.

Language: Английский

Citations

0
Antibacterial Polymers Based on Two Orthogonal Binding Motifs Coalesce with Bacterial Matter DOI
Esteban Bautista,

Eduardo Estrada,

Jacob Deyell

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Addressing the growing concern about antibiotic-resistant bacteria, we have developed a series of polymers exhibiting intrinsic antibacterial activities with dual-targeting system that induces physical lysis upon copolymer coalescence bacterial matter. These are equipped two orthogonal binding motifs form electrostatic interactions and dynamic covalent complexes on surfaces exhibit potent activity against Gram-positive Gram-negative bacteria. The effect chemical composition architecture copolymers incorporating phenylboronic acid quaternary ammonium groups antimicrobial was systematically examined. This work expands current repertoire to combat resistance by intrinsically unique mode action.

Language: Английский

Citations

0
Scalable and precise synthesis of polymer nanoparticles DOI
Chun Feng

Nature Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

0