Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 2, 2024
Abstract
The
efficient
construction
of
chalcogen‐atom‐based
chiral
compounds
remains
a
challenge,
despite
the
importance
organoselenium
and
organosulfur
in
life
materials
science.
Chalcogen
atoms
can
form
net
attractive
interactions
called
chalcogen
bonds,
but
it
is
an
undeveloped
tool
to
assist
asymmetric
catalysis.
Herein,
we
report
enantioselective
insertion
platform
install
stereogenic
center
bearing
selenyl
thiocyano
functional
groups.
Our
method
operates
by
synergistic
catalysis
guanidine
achiral
dirhodium
complex
three‐component
or
four‐component
reaction,
through
Se−S
bond
into
carbene
species,
competing
successfully
with
spontaneous
racemic
process
showing
high
regioselectivity.
As
elucidated
spectroscopic
experiments
computational
studies,
unique
mechanism
involving
as
well
hydrogen
bonding
was
established
account
for
enantiocontrol.
stereoselectivity
holds
broad
array
selenylthiocyanatopropanoates,
which
showed
excellent
anti‐inflammatory
toward
IL‐1β
low
cytotoxicity.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(27)
Published: May 21, 2024
Abstract
The
direct
functionalization
of
quinones
has
always
fascinated
research
communities
due
to
their
biological
and
redox
activities
subsequent
application.
Quinone
motifs
play
a
vital
role
as
precursors
for
many
bioactive
compounds
materials;
hence,
ingenious
methodologies
have
been
elaborated
exploring
these
units.
A
significant
part
the
synthetic
strategies
towards
functionalized
achieved
by
installing
substituents
on
hydroquinones,
phenols,
or
quinone
itself
different
oxidative
coupling
reactions
via
radical
pathways
with
without
utilization
metal
catalysts.
simple
C−H
bond
remains
challenging
inherited
electronic
nature
high
dissociation
energy.
This
review
article
summarizes
recent
advancement
made
through
quinones.
Our
primary
focus
will
be
approaches
mechanistic
that
appeared
in
last
two
decades,
along
short
historical
importance
family.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 11, 2024
The
electrochemical
hydrogen
evolution
reaction
(HER)
is
currently
recognized
as
a
prospective
way
to
obtain
clean
energy.
electrocatalysts
used
are
dominantly
based
on
transition
metals.
In
this
work,
we
have
demonstrated
diazaphospholene
(
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 480 - 480
Published: Jan. 22, 2025
Selenium
reagents
are
useful
for
selenoenzyme-mimicking
reactions,
as
well
organic
synthesis.
However,
the
reaction
waste
containing
selenium
frequently
smells
unpleasant
and
exhibits
serious
toxicity.
Herein,
we
have
developed
new-type
on-resin
reagents,
H-UXX···-PAM
(5)
Ac-(X)U*XX···-PAM
(6),
where
U
U*
represent
selenocysteine
(U)
p-methoxybenzyl
(PMB)-protected
U,
respectively,
recyclable
catalysts,
in
which
U-containing
peptide
chains
linked
to
polystyrene
resin
PAM.
Synthesized
selenopeptides
5a–g
with
a
variable
amino
acid
sequence
were
evaluated
their
glutathione
peroxidase
(GPx)-like
activity
using
UV
1H
NMR
methods,
between
dithiothreitol
(DTTred)
H2O2
methanol.
It
was
found
that
intramolecular
interaction
basic
residue,
such
histidine
(H)
lysine
(K),
enhances
through
formation
of
an
NH···Se
hydrogen
bond.
On
other
hand,
catalytic
6a–d
oxidative
cyclization
β,γ-unsaturated
acids
(7)
into
α,β-unsaturated
lactones
(8).
Although
yield
8
significantly
decreased
after
second-
or
third-round
reaction,
due
detachment
moiety
from
resin,
results
demonstrated
reusability,
substrate
scope
6
catalyst.
Since
is
natural
acid,
potential
targets
novel-type
green
redox
catalysts.
ChemElectroChem,
Journal Year:
2024,
Volume and Issue:
11(13)
Published: April 15, 2024
Abstract
Developing
efficient
and
stable
catalysts
for
energy
conversion
processes
such
as
alkaline
oxygen
evolution
reaction
is
one
of
the
key
measures
to
solve
shortage
problems.
During
evolution,
several
electrocatalysts
would
undergo
structural
reconstruction
from
pre‐catalyst
state
real‐catalyst
state.
The
may
modify
quantity
characterizations
active
sites,
thus
affecting
configuration
adsorption
strength
intermediates,
which
directly
influence
activity
stability
electrocatalysts.
Understanding
transformation
chemistry
essential
rational
design
highly
In
this
review,
we
have
deeply
discussed
role
regulation
strategies
reconstruction.
Then,
on
basis,
described
some
characterization
technologies
probe
during
OER.
Finally,
put
forward
views
future
research
direction
vital
field.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
thermodynamics
of
diazaphospholenes
suggest
a
good
balance
between
hydricity
and
regeneration
capacity
(
via
electron
reduction),
inspiring
us
to
identify
privileged
organocatalysts
for
electrochemical
hydrogen
evolution
reactions.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 2, 2024
The
efficient
construction
of
chalcogen-atom-based
chiral
compounds
remains
a
challenge,
despite
the
importance
organoselenium
and
organosulfur
in
life
materials
science.
Chalcogen
atoms
can
form
net
attractive
interactions
called
chalcogen
bonds,
but
it
is
an
undeveloped
tool
to
assist
asymmetric
catalysis.
Herein,
we
report
enantioselective
insertion
platform
install
stereogenic
center
bearing
selenyl
thiocyano
functional
groups.
Our
method
operates
by
synergistic
catalysis
guanidine
achiral
dirhodium
complex
three-component
or
four-component
reaction,
through
Se-S
bond
into
carbene
species,
competing
successfully
with
spontaneous
racemic
process
showing
high
regioselectivity.
As
elucidated
spectroscopic
experiments
computational
studies,
unique
mechanism
involving
as
well
hydrogen
bonding
was
established
account
for
enantiocontrol.
stereoselectivity
holds
broad
array
selenylthiocyanatopropanoates,
which
showed
excellent
anti-inflammatory
toward
IL-1β
low
cytotoxicity.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(19), P. 14328 - 14340
Published: Sept. 16, 2024
Here,
the
synthesis
and
catalytic
activities
of
benzoimidazole-derived
organoselenium
compounds
have
been
explored.
The
synthesized
bis(2-benzoimidazolyl)
diselenide,
having
increased
Lewis
acidity
on
selenium
center,
outperforms
simple
phenyl
Chemical Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
We
have
demonstrated
the
synthesis
of
regio-
and
diastereoselective
cyclobutylated
phenothiazines
via
[2
+
2]
visible-light-irradiated
cycloaddition
wavelength-gated
cycloreversion
inside
live
cells
for
cell
imaging
drug
delivery.
