GalNAc modified FeS nanoparticles for specific chemodynamic and gas therapy against orthotopic hepatocellular carcinoma DOI
Yanhua Li,

Yingying Song,

Jiaqi Yin

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(78), P. 10882 - 10885

Published: Jan. 1, 2024

GalNAc-modified ferrous sulfide nanoparticles have been developed to conduct chemodynamic and gas therapy for fighting against orthotopic hepatocellular carcinoma. This nanomedicine owns good liver targeting ability, which takes full advantage of the tumor microenvironment ensure effect improve safety.

Language: Английский

A Novel CRISPR/Cas9‐Encapsulated Biomimetic Manganese Sulfide Nanourchins for Targeted Magnetic Resonance Contrast Enhancement and Self‐Enhanced Chemodynamics‐Gene‐Immune Synergistic Tumor Therapy DOI
Hui Liu,

Mengyao Mu,

Yuebing Hou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract CRISPR/Cas9 gene editing systems are widely studied in cancer therapy, however, it is still challenging to improve the efficiency and enhance anticancer efficacy. Herein, a novel self‐assembled manganese sulfide nanourchin with hybrid membrane encapsulation (MCRT) developed highlight synergistic mechanism of hydrogen (H 2 S) therapy. The special structure cationic surface nanourchins facilitate loading large size erythrocyte‐tumor cell membrane, endowing nanoplatform long circulation precise tumor targeting. MCRT pH‐response can effectively decompose into H S Mn 2+ , release acidic microenvironment. up‐regulate intracellular peroxide level by inhibiting activity catalase, which enables self‐enhanced chemodynamic therapy (CDT) . In addition, synergize released CRISPR/Cas9, co‐downregulating anti‐apoptotic protein survivin, achieving Furthermore, systemic delivery displays significantly magnetic resonance imaging (MRI) contrast enhancement. Importantly, S‐enhanced CDT‐gene simultaneously induces immunogenic death triggered robust anti‐tumor immune response. Thus, has potential application for targeted MRI CDT‐gene‐immune

Language: Английский

Citations

17
Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT DOI

Xinxin Lu,

Chun Xue,

Jianhui Dong

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3209 - 3225

Published: Jan. 1, 2024

This review summarizes the recent advances of nanoplatform-based strategies to efficiently amplify tumoricidal capability PDT.

Language: Английский

Citations

10
Photodynamic therapy with NIR-II probes: review on state-of-the-art tools and strategies DOI
Yiqian Yang, Shaohua Jiang, Stefan G. Stanciu

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5815 - 5842

Published: Jan. 1, 2024

The current state-of-the art on NIR-II-activated photosensitizers and their applications for the deep tumor treatment, as well recent efforts that combine NIR-II activated PDT with other complementary therapeutic routes.

Language: Английский

Citations

8
Glutathione-Responsive and Hydrogen Sulfide Self-Generating Nanocages Based on Self-Weaving Technology To Optimize Cancer Immunotherapy DOI

Shuangquan Gou,

Wenbo Geng,

Yanan Zou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(14), P. 9871 - 9885

Published: March 28, 2024

As an ideal drug carrier, it should possess high loading and encapsulation efficiency precise targeting release. Herein, we utilized a template-guided self-weaving technology of phase-separated silk fibroin (SF) in reverse microemulsion (RME) to fabricate kind hyaluronic acid (HA) coated SF nanocage (HA-gNCs) for delivery cancer immunotherapy. Due the hollow structure, HA-gNCs were capable simultaneous anti-inflammatory betamethasone phosphate (BetP) immune checkpoint blockade (ICB) agent PD-L1 antibody (αPD-L1) efficiently. Another point worth noting was that thiocarbonate cross-linkers used strengthen shell could be quickly broken by overexpressed glutathione (GSH) reach responsive release inside tumor tissues accompanied hydrogen sulfide (H2S) production one step. The synergistic effect released BetP generated H2S guaranteed chronological modulation immunosuppressive microenvironment (ITME) amplify therapeutic αPD-L1 growth, metastasis, recurrence tumors. This study highlighted exceptional prospect as self-assistance platform delivery.

Language: Английский

Citations

4
Acid-Triggered Degradation of Three-In-One Ag2S Quantum Dots for In Situ Ratiometric NIR-II Fluorescence Imaging-Guided Ion/Gas Combination Therapy DOI

Xiaolan Tang,

Zhihong Zhou,

Liu-Yan Zhou

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(19), P. 7687 - 7696

Published: May 2, 2024

Smart theranostic nanoprobes with the integration of multiple therapeutic modalities are preferred for precise diagnosis and efficient therapy tumors. However, it remains a big challenge to arrange imaging two or more kinds agents without weakening intended performances. In addition, most existing fluorescence (FL) suffer from low spatiotemporal resolution due short emission wavelength (<900 nm). Here, novel three-in-one Ag2S quantum dot (QD)-based smart were proposed in situ ratiometric NIR-II FL imaging-guided ion/gas combination Under acidic tumor microenvironment, QDs underwent destructive degradation, generating toxic Ag+ H2S. Meanwhile, their at 1270 nm was weakened. Upon introduction downconversion nanoparticle (DCNP) as delivery carrier reference signal unit, formed QD-based could achieve tumors through signals. Also, generated H2S enabled specific toward By combining functions, may open simple yet reliable avenue design nanoprobes.

Language: Английский

Citations

4
Regulation of ROS balance in the tumor microenvironment achieves reversal of immune suppression and deep penetration of nanomedicines DOI

Zichuang Xu,

Rongrong Fan, Xuhao Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159716 - 159716

Published: Jan. 1, 2025

Language: Английский

Citations

0
Tumor Microenvironment-Responsive Biodegradable Multifunctional Nanomaterials for the Explosive Release of H2S Gas and Enhanced Tumor Therapy DOI
Junqing Huang,

Xingwang Wen,

Songjun Zeng

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

0
Recent advances of fluorescent probe for the conjugated enzymes closely related to clinical diseases DOI

Ren-Wei-Yang Zhang,

Han Zhang, Li Qiu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216471 - 216471

Published: Jan. 28, 2025

Language: Английский

Citations

0
Dual-Locked Near-Infrared Fluorescent Probe for Real-Time Imaging of Hydrogen Sulfide/Matrix Metallopeptidase-2 In Vivo DOI
Luyan Wu, Qiang Tong,

Xiang Cao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Hydrogen sulfide (H2S) and matrix metallopeptidase 2 (MMP-2) are inextricably linked in the occurrence development of diseases treatment diseases. However, most activatable imaging probes currently developed single-locked that do not simultaneously detect H2S MMP-2 levels at disease sites severely hinder real-time accurate analysis dynamic relationship between two interrelated biomarkers. Herein, we report a dual-locked H2S/MMP-2-activatable near-infrared (NIR) fluorescent probe through dual-Förster resonance energy transfer (FRET) mechanism specifically detects tumors or acute lung injury (ALI) establishes level expression. Initially, fluorescence is turned off due to from methylene blue (MB) both cationic electrochromic material (dicationic 1,1,4,4-tetraarylbutadiene, EM 12+) quencher QSY21. Upon reaction with H2S/MMP-2 ALI, NIR activated, enabling ALI. Additionally, this precisely tracks effects exogenous glucocorticoids for ALI on expression, providing powerful molecular tool early prediction outcomes

Language: Английский

Citations

0
Hydrogen sulfide-responsive and depleting NIR-II nanoplatform synergistic photodynamic therapy for colorectal cancer DOI

Yun Chai,

M. Xu,

Ye Sun

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161711 - 161711

Published: March 1, 2025

Language: Английский

Citations

0