Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Sept. 13, 2024
Photocaging is an emerging protocol for precisely manipulating spatial and temporal behaviors over biological activity. However, the red/near-infrared light-triggered photolysis process of current photocage largely singlet oxygen (
Language: Английский
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Liver fibrosis is a major global health problem without effective therapies, and targeted elimination of senescent cells beneficial for hepatic function organism survival. We report new trilocked photodynamic senolytic inducer (PDSI) strategy liver resolution using type-I agent immunogenic clearance cells. demonstrate that this PDSI not only facilitates efficient production superoxide anions (O2•-) in lysosomes therapy, but also permits NIR fluorescence photoacoustic (NIRF/PA) imaging Mechanistic investigation reveals the elicited cell predominantly via necroptosis pathway. Moreover, with liver-targeting moiety enables high-contrast NIRF/PA vivo. This exhibits remarkable ablation cells, enhancing dendritic maturation cytotoxic T recruitment fibrosis. Our study highlights potential type I boosting immunity treatment.
Language: Английский
Citations
0
ACS Macro Letters, Journal Year: 2024, Volume and Issue: unknown, P. 1251 - 1257
Published: Sept. 11, 2024
The prevailing design philosophy for polymeric vectors delivering siRNA is rooted in the post-transcriptional gene silencing (PTGS) mechanism. Yet, transcriptional (TGS) mechanism offers a potentially more durable effect, which necessitates efficient delivery into nucleus. However, it remains challenge to efficiently deliver We have explored guanidinylated cyclic synthetic polypeptides (GCSPs) enhance nuclear of siRNA, but an increased cytotoxicity and difficulty producing GCSPs on large scale limit their utility. Herein, we simply prepare PEGylated linear (PGLSPs) exhibiting improved membrane penetration, direct transport nucleus, reduced toxicity, high cellular uptake, mitigation protein corona formation. PEGylation can effectively balance vector's capacity with other critical aspects performances delivery. Therefore, PGLSPs hold promise as TGS-based vectors, offering potential future therapeutic applications.
Language: Английский
Citations
2
Chem & Bio Engineering, Journal Year: 2024, Volume and Issue: 2(3), P. 132 - 155
Published: Dec. 23, 2024
Proteins are an important therapeutic modality in modern medicine. However, their inherent inability to traverse cell membranes essentially limits application extracellular targets. Recent advances intracellular protein delivery have enabled access traditionally "undruggable" targets and paved the way precisely modulate cellular functions. This Review provides a comprehensive examination of key mechanisms emerging technologies that facilitate transport functional proteins across membranes. Delivery methods categorized into physical, chemical, biological approaches, each with distinct advantages limitations. Physical enable direct entry but often pose challenges related invasiveness technical complexity. Chemical strategies offer customizable solutions enhanced control over targeting uptake, yet may face issues cytotoxicity scalability. Biological approaches leverage naturally occurring processes achieve efficient transport, though regulatory production consistency remain hurdles. By highlighting recent advancements, challenges, opportunities within approach, this review underscores potential unlock new pathways transform drug development paradigms.
Language: Английский
Citations
1
Nanoscale, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 6, 2024
This work presents a novel tumor microenvironment-activated photosensitizer employed for the combined action of photodynamic therapy (PDT) and chemodynamic (CDT), which synergistically functions to effectively kill cells.
Language: Английский
Citations
0
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)
Published: Sept. 13, 2024
Abstract Photocaging is an emerging protocol for precisely manipulating spatial and temporal behaviors over biological activity. However, the red/near‐infrared light‐triggered photolysis process of current photocage largely singlet oxygen ( 1 O 2 )‐dependent lack compatibility with other reactive species (ROS)‐activated techniques, which has proven to be major bottleneck in achieving efficient precise treatment. Herein, we reported a lactosylated BT‐LRC by covalently incorporating camptothecin (CPT) into hybrid BODIPY‐TPE fluorophore via superoxide anion radical (O − ⋅)‐cleavable thioketal bond type I photodynamic therapy (PDT) anticancer drug release. Amphiphilic could self‐assembled aggregation‐induced emission (AIE)‐active nanoparticles (BT‐LRCs) owing regulation carbohydrate‐carbohydrate interactions (CCIs) among neighboring lactose units nanoaggregates. BT‐LRCs simultaneously generate abundant ⋅ through aggregation modulated interactions, DNA‐damaging agent CPT was subsequently effectively released. Notably, PDT chemotherapy collaboratively amplified therapeutic efficacy HepG2 cells tumor‐bearing mice. Furthermore, inherent AIE property endowed photocaged prodrug superior bioimaging capability, provided powerful tool real‐time tracking finely tuning photoactivated release behavior tumor therapy.
Language: Английский
Citations
0
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Sept. 13, 2024
Photocaging is an emerging protocol for precisely manipulating spatial and temporal behaviors over biological activity. However, the red/near-infrared light-triggered photolysis process of current photocage largely singlet oxygen (
Language: Английский
Citations
0