Metal‐Organic Framework PCN‐224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(36)

Published: April 12, 2024

Abstract Photodynamic therapy (PDT) and chemodynamic (CDT) are promising tumor treatments mediated by reactive oxygen species (ROS), which have the advantages of being minimally invasive. However, hypoxia microenvironment poor target ability often reduce therapeutic effect. Here we propose a targeted nanoplatform PCN‐224@Co 3 O 4 ‐HA for enhanced PDT synergistic CDT, constructed hyaluronate‐modified Co nanoparticles decorated metal‐organic framework PCN‐224. can catalyze decomposition highly expressed H 2 in cells to produce alleviate problem hypoxia. It also hydroxyl radicals according Fenton‐like reaction chemical dynamic therapy, significantly improving The cell survival experiment showed that after vitro treatment, 4T1 MCF‐7 cancer died large area under anaerobic state, while normal L02 was nearly unchanged. This result effectively indicated could relieve improve effect CDT. Cell uptake experiments had good targeting properties aggregate cells. In vivo on mice, presented reliable biosafety performance, cooperate with CDT prevent growth tumor.

Language: Английский

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Light‐Responsive Nanoantennas Integrated into Nanoscale Metal–Organic Frameworks for Photothermal Drug Delivery

Small Science, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 10, 2024

Nanoscale metal-organic frameworks (NMOFs) exhibit unique properties for drug delivery, including ultrahigh storage capabilities, biocompatibility, biodegradability, and sustained release of encapsulated cargo. However, due to their localized electronic states, MOFs are nonresponsive external stimuli such as light or magnetic fields. This study investigates the integration light-responsive nanoantennas into NMOFs enhance application smart delivery nanosystems. By integrating gold bipyramid within ZIF-8 NU-1000 NMOFs, core@shell nanosystems created with photothermal capabilities. Utilizing cresyl violet a model drug, loading dynamics these analyzed, demonstrating controlled under near-infrared (NIR) stimulation. Photothermal studies conducted in living cells reveal potential nanocomposites spatiotemporal targeted, light-activated delivery. Further evaluation nanocomposite loaded chemotherapeutics-doxorubicin, carboplatin, oxaliplatin-in both 2D 3D cell cultures shows nanosystem effectiveness internalization therapeutic NIR activation. The findings demonstrate that incorporation stimuli-responsive elements offers promising approach developing advanced platforms.

Language: Английский

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Photo‐Facilitated Nitric Oxide‐Triggered Turn‐on Photodynamic Therapy for Precise Antitumor Application

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Photodynamic therapy (PDT) is a powerful strategy for tumor with noninvasiveness and desirable efficacy. However, the phototoxicity of photosensitizer after post‐PDT major obstacle limiting clinic applications. Herein, nitric oxide (NO)‐activatable reported turn‐on PDT behavior endoplasmic reticulum (ER) targeting ability precise therapy. Four o ‐thiophenediamine derivatives reaction‐tunable donor/acceptor push‐pull electronic effect are established, systematic structure property relationship observation reveals following features: 1) reactivity against NO can be improved by enhancing electron density further facilitated upon photo‐irradiation. 2) enables intramolecular charge transfer process evoking photosensitizing effect. 3) only derivative ER enrichment exhibited cancer cell ablation compared to photosensitizers localized in lysosome lipid droplet. Thus, efficient inhibition cells both vitro vivo realized based on photo‐controlled strategy. This work provides more insights into developing promising activatable advanced microenvironment trigger.

Language: Английский

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Catalytic Hydrolysis of Perfluorinated Compounds in a Yolk–Shell Micro‐Reactor

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Perfluorinated compounds (PFCs) are emerging environmental pollutants characterized by their extreme stability and resistance to degradation. Among them, tetrafluoromethane (CF 4 ) is the simplest most abundant PFC in atmosphere. However, highest C─F bond energy its highly symmetrical structure make it particularly challenging decompose. In this work, a yolk–shell Al 2 O 3 micro‐reactor developed enhance catalytic hydrolysis performance of CF creating local autothermic environment. Finite element simulations predict that captures heat released during , resulting environment within 50 °C higher than set temperature. The effectiveness experimentally confirmed situ Raman spectroscopy. As result, obtained achieves 100% conversion at considerably low temperature 580 for over 150 h, while hollow solid structures required temperatures 610 630 °C, respectively, achieve same rate, demonstrating potential significantly reduce requirements PFCs degradation contribute more sustainable effective remediation strategies.

Language: Английский

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Dually fluorinated unimolecular micelles for stable oxygen-carrying and enhanced photosensitive efficiency to boost photodynamic therapy against hypoxic tumors

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Core–Satellite Nanoassembly Overcomes Spatial Heterogeneity of Dendric Cell Distribution in Pancreatic Tumors for Effective Chemoimmunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Pancreatic cancer therapies such as chemotherapy and immunotherapy are hindered by the dense extracellular matrix known physical barriers, leading to heterogeneity impeding effective penetration of chemotherapeutic agents activation antitumor immune responses. To address this challenge, we developed a hybrid nanoassembly with distinct core-satellite-like heterostructure, PLAF@P/T-PD, which is responsive both internal pH/redox external ultrasound stimulations. This heterostructural features polymersome core encapsulating an contrast agent perfluoropentane Taxol (PLAF@P/T) electrostatically coated satellite-like polyplexes carrying agonist dsDNA (PD), brings about synergistic functions inside pancreatic tumor. The PLAF@P/T enhancer for intratumor delivery through size enlargement charge conversion in response reactive oxygen species (ROS) low pH, triggers polyplex release enables ultrasound-assisted tumor-penetrating delivery. Meanwhile, released cationic function nucleic nanomedicine preferentially engulfed peripheral dendritic cells (DCs) modulation. Animal studies mouse orthotopic tumor model demonstrated exceptional therapeutic efficacy against primary metastatic tumors, underlines potential nanoplatform overcoming challenges associated heterogeneous barrier hindering drug treatment.

Language: Английский

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Boosting Peroxidase-Mimetic Activity of FeMn-NC_e Dual-Atom Radiosensitizing Nanozymes for Augmented Radiodynamic Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.

Language: Английский

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Fluorinated Cyclodextrin Supramolecular Nanoassembly Enables Oxygen-Enriched and Targeted Photodynamic Therapy

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Photodynamic therapy has become a promising treatment modality against many diseases, but its dilemma―the intrinsic hypoxia of solid tumors and the high oxygen dependence for generation cytotoxic species―has seriously hampered practical translation. Herein binary supramolecular nanocarrier, which is composed fluorocarbon chain-appended β-cyclodextrin as an carrier adamantane-grafted hyaluronic acid cell-targeting agent, can deliver different types photosensitizers by multiple noncovalent interactions. Superior to alkylated counterpart, fluorinated amphiphilic spontaneously form nanoparticulate assembly exhibit oxygen-enrichment performance. The obtained nanoassembly alleviate in tumor microenvironment enhance efficacy photodynamic therapy. Remarkable phototoxicity minimal dark toxicity are observed cancer cells, meanwhile, preferential accumulation significant ablation realized tumor-bearing mice. To be envisioned, this capable efficiently carrying explored universal platform precise phototherapeutics.

Language: Английский

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Tactics to Improve the Photodynamic Therapeutic Efficacy Based on Nanomaterials

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Comprehensive Summary The development of photodynamic therapy (PDT), from its initial discovery effects to current use in various medical conditions, is a testament therapeutic potential. Recent breakthroughs nanotechnology have significantly enhanced the effectiveness PDT. Typical nanomaterials (NMs), including metal‐organic frameworks (MOFs), covalent organic (COFs), and nanozymes been introduced enhance efficacy because they can delivery PSs, effectively overcome insufficient targeting specificity, limited tissue penetration depth, hypoxic microenvironments, thereby amplifying efficacy. However, clinical application these NMs PDT faces several challenges, concerns regarding biocompatibility, long‐term biosafety, economic feasibility. To further advance PDT, researchers should focus on designing improve outcomes, exploring combination therapies with conducting translational trials validate safety novel approaches. This review summarizes recent progress based NMs, especially MOFs, COFs their disease treatment. We aim provide guidance for future research practice advancing NMs‐enhanced paving way more effective strategies. Key Scientists

Language: Английский

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Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216207 - 216207

Published: Sept. 13, 2024

Language: Английский

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