Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording DOI Creative Commons
Jingquan Liu,

Zhiyuan Du,

Qingda Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Language: Английский

Electrochemiluminescence Microscopy DOI Creative Commons
Sara Knežević, Dongni Han, Baohong Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: May 14, 2024

Electrochemiluminescence (ECL) is rapidly evolving from an analytical method into optical microscopy. The orthogonality of the electrochemical trigger and readout distinguishes it classic microscopy techniques, owing to its near-zero background, remarkable sensitivity, absence photobleaching phototoxicity. In this minireview, we summarize recent advances in ECL imaging technology, emphasizing original configurations which enable biological entities improvement properties by increasing complexity multiplexing bioassays. Additionally, mapping (electro)chemical reactivity space provides valuable information on nanomaterials facilitates deciphering mechanisms for improving their performances diagnostics (electro)catalysis. Finally, highlight achievements at ultimate limits single molecules, photons or chemical reactions, current challenges translate other fields such as material science, catalysis biology.

Language: Английский

Citations

23
Zero-Background Dual-Mode Closed Bipolar Electrode Electrochemiluminescence Biosensor Based on ZnCoN-C Potential Regulation for Ultrasensitive Detection of Ochratoxin A DOI
Hongkun Li, Qianqian Cai, P. Li

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

In this work, the relationship between electrochemiluminescence (ECL) signal and driving voltage was first studied by self-made reduced oxidized closed bipolar electrodes (CBPEs). It found that when large enough, maximum ECL signals for two kinds of CBPEs were same but their required drive voltages different. Zinc cobalt nitrogen doped carbon material (ZnCoN-C) had an outstanding electric double layer (EDL) property conductivity. Therefore, it could significantly reduce CBPE systems, reaching Ru(bpy)32+. Interestingly, ZnCoN-C modified electrode reached signal, bare zero. As a proof-of-concept application, zero-background dual-mode CBPE-ECL biosensor constructed ultrasensitive detection ochratoxin A (OTA) in beer. Considering beer samples contained number reducing substances, system selected to build biosensor. Furthermore, convenient imaging platform using smartphone built OTA. This work used unique EDL regulate time; thus, novel sensor constructed. Further, provided deeper understanding opened new door detection.

Language: Английский

Citations

9
Intensified electrochemiluminescence and photoluminescence via supramolecular anion recognition interactions DOI Creative Commons
Jun Kee Cheng, Liuqing Yang, Ruiyao Wang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12291 - 12300

Published: Jan. 1, 2024

Herein, intensified electrochemiluminescence (ECL) and photoluminescence (PL)

Language: Английский

Citations

4
Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording DOI Creative Commons

Zhiyuan Du,

Qingda Xu,

Ye Xi

et al.

Microsystems & Nanoengineering, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 23, 2025

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Language: Английский

Citations

0
Circularly Polarized Luminescence Inversion in AIE‐Active Crystal Enabled by Solvent‐Induced Transition Dipole Moment Regulation DOI Creative Commons

Xiaofei Niu,

Xinwen Ou,

Shizhe Ren

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

ABSTRACT Control of the dissymmetry circularly polarized luminescence (CPL) is intriguing and has great potential for applications in field optics. The traditional control strategy involves using opposite enantiomers to achieve reversal CPL signs. However, regulating by controlling only transition dipole moments without changing molecular or supramolecular chirality remains a challenge. Herein, we developed couple crystal materials based on axially chiral aggregation‐induced emission luminogens (AIEgens). These exhibit achiral solvent‐induced sign inversion with identical helical structures their crystalline states. ( R )‐BPAuCz T displays (+)‐CPL factor g lum ) value +9.81 × 10 −4 (560 nm), while C exhibits (−)‐CPL −1.02 −3 nm). Time‐dependent density functional theory calculations show that magnetic electric at S 1 → 0 unit cell are considerably influenced cocrystallized solvent molecules, revealing mechanism. nonbonding interactions between molecules (i.e., tetrahydrofuran CDCl 3 AIEgens play crucial role manipulation moment these materials. Moreover, microrods , DCE optical waveguide properties relatively low optical‐loss coefficients 187.3, 567.4, 65.2 dB/cm, respectively. findings can help developing new toward signals providing application future integrated photonic circuits.

Language: Английский

Citations

0
Electrochemiluminescence of N,N′-Dimethylformamide Passivated Black Phosphorus Quantum Dots DOI
Shuijian He, Weihan Li, Minsi Li

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Black phosphorus quantum dots (BPQDs) have shown promising applications in biosensors and energy storage devices. However, the electrochemiluminescence (ECL) properties of pristine BPQDs an organic system rarely been reported. In this paper, N,N′-dimethylformamide passivated with a small size 2.3 nm were obtained by ultrasonication-assisted liquid exfoliation process, their ECL studied. A reversible reduction peak was recorded differential pulse voltammetry, while no apparent oxidation observed. signal not seen annihilation route. Persulfate proved to be effective coreactant yellow emission observed which greatly red-shifted comparison that photoluminescence. is believed generated from both surface states electron promotion over band gap.

Language: Английский

Citations

3
Protein-Induced Electrochemiluminescence Enhancement of Tetraphenylvinyl Derivatives for Ultrasensitive Bioanalysis DOI
Pan Zhou, Xiaochun Zhu, Xiaofeng Wang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(49), P. 19473 - 19482

Published: Nov. 29, 2024

Herein, the bovine serum albumin (BSA)-loaded tetrakis[4-(4′-cyanophenyl)phenyl]ethane nanoaggregates (NAs) (BSA@TBPE-(CN)4 NAs) as a novel electrochemiluminescence (ECL) emitter were first prepared, which exhibited superior ECL performance via newly defined protein-induced enhancement. Impressively, BSA not only restricted intramolecular motions by its hydrophobic cavity to improve optical radiation for enhancing efficiency but also promoted electrochemical excitation of BSA@TBPE-(CN)4 NAs in amino acid residues altered surface states and narrowed energy gap further boosting efficiency. Furthermore, displayed more dispersed state due electrostatic repulsion caused considerable negative charges, was conducive reacting fully with coreactants improving emission. Excitingly, threefold stronger intensity 4.8-fold higher compared those TBPE-(CN)4 NAs. Thus, an application, biosensor fabricated based on efficient mismatch-fueled three-dimensional (3D) DNA walker effective signal amplifier rapid ultrasensitive detection microRNA-21 limit (LOD) 19.1 aM, it successfully applied assess expression human cancer cells MCF-7 HeLa. This work developed avenue reasonably synthesize highly organic emitters motivating their potential application biosensing high-resolution bioimaging.

Language: Английский

Citations

1
Electrochemiluminescence Microscopy DOI Creative Commons
Sara Knežević,

Dongni Han,

Baohong Liu

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(29)

Published: May 14, 2024

Abstract Electrochemiluminescence (ECL) is rapidly evolving from an analytical method into optical microscopy. The orthogonality of the electrochemical trigger and readout distinguishes it classic microscopy techniques, owing to its near‐zero background, remarkable sensitivity, absence photobleaching phototoxicity. In this minireview, we summarize recent advances in ECL imaging technology, emphasizing original configurations which enable biological entities improvement properties by increasing complexity multiplexing bioassays. Additionally, mapping (electro)chemical reactivity space provides valuable information on nanomaterials facilitates deciphering mechanisms for improving their performances diagnostics (electro)catalysis. Finally, highlight achievements at ultimate limits single molecules, photons or chemical reactions, current challenges translate other fields such as material science, catalysis biology.

Language: Английский

Citations

0
C─H Activation Enables the Construction of New Bis‐Polyaryl Phenylpyridine Ruthenium Complexes: Conjugation and Rigidity Synergistic Effect for Advanced Electrochemiluminescence DOI

Fazal Malik,

Yuzhu Sun,

Huiping Lv

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 16, 2024

Abstract The access to bench‐stable organometallic compounds unfolds new chemical space for medicinal and material sciences. In particular, stable organoruthenium with constitutional stereoisomeric forms subtle regulation of electrochemiluminescence are intriguing challenging. Here, coordination polycyclic aromatic hydrocarbons on (2‐phenylpyridine) 2 (CO) Ru complex allows bis‐polyaryl phenylpyridine (BPP) Ruthenium through C─H activation strategy coupling reactions installation the functionalities steric electronic purposes. photoluminescence BPP complexes affected by actual inherent properties. anthracene derivatized ( BPP‐Ant ) shows best ECL performance reveals an enormous quantum efficiency 1.6‐fold higher than golden standard Ru(bpy) 3 2+ . unprecedentedly high is due compromise between structural conjugation molecular rigidity from providing a providential energy gap that facilitated feasibility electron transfer favored radiative release experimentally DFT calculations. Moreover, PL spooling spectroscopies used track link multiple emission peaks at 445, 645, 845 nm different emissive species. These discoveries will add member efficient ruthenium family bring more potentials.

Language: Английский

Citations

0
Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording DOI Creative Commons
Jingquan Liu,

Zhiyuan Du,

Qingda Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Language: Английский

Citations

0