Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 30, 2024
Abstract
Metal
mediated
several
organic
reactions
are
known
which
can
be
used
inside
the
cellular
medium
for
protein
modifications,
eventually
targeting
diseases.
Indeed,
due
to
their
ease
of
handling,
rapid
solubility,
and
effective
cell
penetration,
metals
superior
than
any
other
competitor
as
a
stimulus/mediator
in
relevant
with
modifications.
most
chemical
biology
tool
Cu(I)‐catalyzed
azide‐alkyne
cycloaddition(CuAAC)/click
or
Pd
multiple
intra/extra
modifications
etc.
A
few
examples
Au(III),
Ru(III)
also
known.
Among
these,
click
reaction
has
high
potential
management
biomolecules
within
cells,
thus
this
methodology
is
adopted
broadly
chemistry,
towards
therapeutic
applications
pharmacology.
Fast
kinetics
aqueous
at
ambient
normal
temperature
specificity
between
precursors
(e.
g.,
azide
alkyne
bio‐orthogonal
cells)
essential
aspects
behind
success
metal
intracellular
reactions.
This
review
dealt
specifically
live
achievements
challenges.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Photosensitizer‐assisted
photocatalytic
systems
offer
a
solution
to
overcome
the
limitations
of
inherent
light
harvesting
capabilities
in
catalysts.
However,
achieving
efficient
charge
transfer
between
dissociative
photosensitizer
and
catalyst
poses
significant
challenge.
Incorporating
photosensitive
components
into
reactive
centers
establish
well‐defined
channels
is
expected
effectively
address
this
issue.
Herein,
electrostatic‐driven
self‐assembly
method
utilized
integrate
photosensitizers
metal–organic
frameworks,
constructing
atomically
Ru‐Cu
bi‐functional
units
promote
local
electron
migration.
Within
newly
constructed
system,
[Ru(bpy)
2
]
2+
component
Cu
site
serve
as
catalytic
active
for
photocarrier
generation
H
O
production,
respectively,
their
integration
significantly
reduces
barriers
transfer.
Ultrafast
spectroscopy
situ
characterization
unveil
accelerated
directional
over
units,
presenting
orders
magnitude
improvement
systems.
As
result,
37.2‐fold
enhancement
rate
(570.9
µmol
g
−1
h
)
that
system
(15.3
achieved.
This
work
presents
promising
strategy
integrating
atomic‐scale
achieve
ultrafast
enhanced
performance.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(47)
Published: Aug. 13, 2024
Abstract
The
field
of
bioorthogonal
chemistry
has
revolutionized
our
ability
to
interrogate
and
manipulate
biological
systems
at
the
molecular
level.
However,
range
chemical
reactions
that
can
operate
efficiently
in
environments
without
interfering
with
native
cellular
machinery,
remains
limited.
In
this
context,
rapidly
growing
area
photocatalysis
offers
a
promising
avenue
for
developing
new
type
tools.
inherent
mildness,
tunability,
chemoselectivity,
external
controllability
photocatalytic
transformations
make
them
particularly
well‐suited
applications
living
systems.
This
minireview
summarizes
recent
advances
technologies,
particular
focus
on
their
potential
enable
selective
generation
designed
products
within
biologically
relevant
or
settings.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: April 13, 2024
The
emerging
field
of
photopharmacology
is
a
promising
chemobiological
methodology
for
optical
control
drug
activities
that
could
ultimately
solve
the
off-target
toxicity
outside
disease
location
many
drugs
treatment
given
pathology.
use
photolytic
reactions
looks
very
attractive
light-activated
release
but
requires
to
develop
sensitive
red
or
near-infrared
light
excitation
better
tissue
penetration.
This
review
will
present
concepts
triplet-triplet
annihilation
upconversion-based
photolysis
and
their
recent
in
vivo
applications
light-induced
delivery
using
photoactivatable
nanoparticles.
ChemMedChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
New
concepts
to
treat
eye
diseases
have
emerged
that
elegantly
combine
unnatural
light
exposure
with
chemical
biology
approaches
achieve
superior
cellular
specificity
and,
as
a
result,
improvement
of
visual
function.
Historically,
without
further
molecular
treatment
has
offered
limited
success
including
photocoagulation
halt
pathological
blood
vessel
growth
or
low
stimulate
retinal
cell
viability.
To
add
such
treatments,
researchers
introduced
various
biological
light-sensing
molecules
and
combined
those
exposure.
(Pre-)clinical
trials
describe
the
use
optogenetics
channelrhodpsins,
i.
e.
light-sensitive
ion
channels,
in
patient
vision
restoration.
In
arena,
pharmacological
agents,
rendered
by
reversible
modification
photosensitive
protecting
compounds
("caging"),
been
applied
eyes
living
mice
photo-release
specific
activities.
Among
these
were
successful
proof-of-principle
experiments
conducted
establish
photo-sensitive
gene
therapies
eye.
For
light-mediated
combination
biology,
we
wish
here
current
frontiers
research
restoration
an
on
differences
between
molecules,
requirements,
future
outlooks.
We
report
two
potentially
biocompatible
photoredox
systems
for
the
activation
and
coupling
of
redox-active
esters
using
low-energy
light
BnNAH
as
reductant.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Selective
inhibition
of
TrxR1
over
TrxR2
is
a
highly
sought-after
goal,
because
the
two
enzymes
play
distinct
roles
in
cancer
progression.
However,
achieving
targeted
challenging
due
to
their
high
homology
and
identical
active
site
sequence.
Herein
we
report
new
subcellular
photocatalysis
approach
for
by
controllably
activating
organogold(I)
prodrugs
within
cytosol,
exclusive
location
TrxR1.
The
NHC-Au(I)-alkynyl
complexes
are
stable
evenly
distributed
cell;
they
can
meanwhile
be
efficiently
transformed
into
NHC-Au(I)-L
species
(L
=
labile
ligands)
via
radical
mechanism
photocatalysts
released
cytosol
(from
endosome/lysosome)
upon
light
irradiation,
leading
selective
without
affecting
TrxR2.
This
results
strong
cytotoxicity
cells
with
much
higher
selectivity
than
auranofin,
pan
TrxR
inhibitor
that
cannot
discriminate
TrxR1/2,
along
potent
antitumor
activities
multiple
zebrafish
mouse
models.
prodrug
activation
may
thus
suggest
novel
precision
targeting
using
remarkable
spatial
control
photocatalysis.
Abstract
Bioorthogonal
chemistry
has
revolutionized
the
field
of
chemical
biology,
providing
powerful
tools
for
manipulating
molecules
in
biological
environments,
including
living
cells
and
organisms.
For
many
years,
these
transformations
have
been
mainly
limited
to
well-known
copper-catalyzed
azide–alkyne
cycloadditions
(CuAAC)
metal-free
reactions
with
strained
reagents.
However,
recent
years
it
widely
demonstrated
that
some
transition-metal-catalyzed
may
also
be
performed
settings,
enabling,
among
other
applications,
bioimaging
targets
structures
or
pro
drug
activations.
Particularly
attractive
is
possibility
using
organometallic
catalysis
performing
synthetic,
bond-forming
reactions,
as
this
can
lead
new
types
technologies
exploration
biomedical
discovery.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(65), P. 8516 - 8525
Published: Jan. 1, 2024
This
review
summarizes
recent
advances
in
the
electrochemically
enabled
construction
of
indoles
from
non-indole-based
precursors
and
their
underlying
mechanisms.
