ChemPhotoChem,
Journal Year:
2024,
Volume and Issue:
8(12)
Published: Aug. 16, 2024
Abstract
The
spectroscopic
investigation
of
the
binding
properties
berberine‐type
9‐aryl‐substituted
isoquinolinium
derivatives
with
G‐quadruplex
DNA
(G4‐DNA)
are
presented.
Photometric
titrations
show
that
these
ligands
bind
high
affinity
to
telomeric
G4‐DNA
form
22AG
(
K
=1.0–44×10
5
M
−2
).
Furthermore,
fluorimetric
analysis
thermal
denaturation
(FRET
melting)
reveals
a
significant
stabilization
upon
association
methoxy‐substituted
derivatives.
As
an
analytically
useful
property,
phenyl
substituent
or
additional
electron‐donating
groups
very
weak
fluorescence
intensity,
which
increased
significantly
complexation
(fluorescence
light‐up
effect).
Additional
time‐resolved
spectroscopy
indicated
lifetimes
DNA‐bound
9‐(4‐methoxyphenyl)‐substituted
derivative,
when
interacting
quadruplex‐forming
strand
.
Notably,
changes
steady‐state
and
emission
ligand
more
pronounced
than
duplex
so
combination
complementary
methods
may
be
used
for
selective
detection.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
9(9), P. 1390 - 1416
Published: Jan. 1, 2024
Molecular
disassembly
is
pioneering
a
new
route
to
refined
diagnostic
and
therapeutic
solutions.
This
approach
breaks
down
self-assembled
molecules,
offering
enhanced
precision
efficiency
in
various
bio-oriented
applications.
Nucleic Acids Research,
Journal Year:
2024,
Volume and Issue:
53(D1), P. D91 - D98
Published: Sept. 25, 2024
Non-canonical
nucleic
acid
structures,
such
as
G-quadruplex
(G4)
and
i-Motif
(iM),
have
garnered
significant
research
interest
because
of
their
unique
structural
properties
biological
activities.
Thousands
small
molecules
targeting
G4/iM
structures
been
developed
for
various
chemical
applications.
In
response
to
the
growing
in
G4-targeting
ligands,
we
launched
first
G4
Ligand
Database
(G4LDB)
2013.
Here,
introduce
G4LDB
3.0
(http://www.g4ldb.com),
an
upgraded
version
featuring
extensive
enhancements
content
functionality.
The
new
includes
over
4800
ligands
approximately
51
000
activity
entries.
Key
upgrades
include
advanced
search
capabilities,
dynamic
knowledge
graphs,
enhanced
data
visualization,
along
with
a
analysis
function
that
automatically
displays
ligand
structure
clustering
results
space
distribution.
With
these
updates,
further
evolves
into
comprehensive
resource
valuable
tool.
improvements
address
increasing
demand
efficient
handling
user
experience,
highlighting
critical
role
advancing
on
G-quadruplexes
i-motifs.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 15, 2024
Near-infrared
region
(NIR;
650-1700
nm)
dyes
offer
many
advantages
over
traditional
with
absorption
and
emission
in
the
visible
region.
However,
developing
new
NIR
dyes,
especially
organic
long
wavelengths,
small
molecular
weight,
excellent
stability
biocompatibility,
is
still
quite
challenging.
Herein,
we
present
a
general
method
to
enhance
wavelengths
of
fluorophores
by
simply
appending
charge
separation
structure,
dihydropyridopyrazine.
These
novel
not
only
exhibited
greatly
redshifted
compared
their
parent
but
also
displayed
weight
increase
together
retained
biocompatibility.
Specifically,
dye
NIR-OX,
dihydropyridopyra-zine
derivative
oxazine
mass
386.2
Da,
an
at
822
nm
extending
1200
nm,
making
it
one
smallest
molecular-weight
NIR-II
emitting
dyes.
Thanks
its
rapid
metabolism
wave-length,
NIR-OX
enabled
high-contrast
bioimaging
assessment
cholestatic
liver
injury
vivo
facilitated
evalua-tion
efficacy
protection
medicines
against
injury.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 14, 2025
ABSTRACT
The
selective
detection
of
G‐quadruplex
DNA
has
the
potential
to
reveal
its
biological
function
and
provide
important
information
for
cancer
diagnosis
treatment.
Herein,
a
ruthenium(II)
complex
containing
two‐armed
benzimidazole
ligand
(bimbpy)
(
RC1
)
been
developed
as
luminescence
probe
toward
G4
DNA.
exhibited
distinguishable
response
DNA,
such
HTDNA,
c‐MYC,
22AG.
Especially,
in
presence
intensity
increased
6.1‐fold.
limit
is
30
nM
HTDNA.
However,
it
showed
small
change
against
doubled‐strand
single‐strand
binding
experimental
results
indicated
that
effectively
stabilized
through
hydrogen
bonds
π‐π
stacking.
selectivity
might
be
due
increase
rigidity
after
Therefore,
design
complexes
with
will
an
effective
method
obtain
Ru(II)‐based
luminescent
probes
by
adjusting
degree
two
arms.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 16, 2025
Abstract
NIR‐II
fluorescence
imaging
has
shown
broad
application
prospects
in
life
science
because
of
its
deeper
tissue
penetration
and
higher
spatiotemporal
resolution.
Developing
fluorophores
with
special
spectroscopic
properties
analytical
functions
become
a
cutting‐edge
but
challenging
topic
this
field.
Herein,
series
azulene‐based
(called
cyazulenes)
adjustable
cycloalkenes
for
applications
is
reported.
Cyazulenes
(CA965,
CA985,
CA1025)
are
constructed
via
the
convenient
coupling
azulene
derivatives.
They
exhibit
different
H‐aggregation
J‐aggregation.
Particularly
noteworthy
that
CA985
can
form
significant
J‐aggregates
strong
sharp
emission
biological
media,
be
used
vivo
blood
vessels
fine
structures
collecting
lymphatics
mice.
Moreover,
displays
passive
bone‐targeted
capacity,
thereby
enabling
bone
imaging.
This
study
demonstrates
chemical
impact
varying
on
aggregate
formation
spectral
cyazulenes,
which
will
advance
fluorophores.
Nanoprobes
with
NIR-II
fluorescence
and
a
large
Stokes
shift
are
highly
desirable
for
high-quality
bioimaging
applications.
However,
designing
fluorescent
nanoprobes
the
desired
photophysical
properties
based
on
small
organic
molecules
remains
significant
challenge.
Herein,
we
report
naphthalimide
(NMI)-based
molecule,
NMI-BF2,
by
further
enhancing
electron
affinity
of
NMI
through
incorporation
boron
difluoride
formazanate.
NMI-BF2
exhibits
sufficient
quantum
yield
(QY)
0.53%,
263
nm,
excellent
photostability.
For
biological
applications,
is
coassembled
fetal
bovine
serum
(FBS)
to
prepare
biocompatible
nanoprobe,
NMI-BF2/FBS,
which
maintains
good
QY
0.21%
photothermal
conversion
efficiency
32.5%.
In
vitro
in
vivo
studies
verified
that
NMI-BF2/FBS
nanoprobe
shows
an
antitumor
therapeutic
effect,
guided
photoacoustic
imaging.
