Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis maintaining redox balance countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) soybean phospholipid (SP) as pyroptosis promoters (Pd

Language: Английский

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Biometallic ions and derivatives: a new direction for cancer immunotherapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

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Aggregable gold nanoparticles for cancer photothermal therapy

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 8048 - 8061

Published: Jan. 1, 2024

Photothermal therapy (PTT) is an important non-invasive cancer treatment method.

Language: Английский

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NanoTrackThera Platform for Real‐Time, In Situ Monitoring of Tumor Immunotherapy and Photothermal Synergistic Efficacy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Cancer is one of the leading causes death worldwide, posing a significant threat to human health. Although immunotherapy has shown promise in cancer treatment, its efficacy often compromised by tumor immune evasion, which hinders treatment outcomes. Therefore, combining with other therapeutic approaches enhance effectiveness become an increasingly accepted strategy clinical practice. In response this need, nanotechnology‐based platform, NanoTrackThera (NTT), enables both combination therapy and real‐time diagnosis, developed. Using nonsmall cell lung (NSCLC) as model, NTT platform integrates photothermal (PTT) activity natural killer (NK) cells, employ checkpoint inhibitors, leverage heat generation from self‐assembled nanoparticles under near‐infrared (NIR) irradiation directly kill cells. Simultaneously, nanoplatform incorporates dual detection capabilities through fluorescence imaging photoacoustic imaging. With these multimodal techniques, can achieve real‐time, situ, tracking biomarker changes during providing precise feedback on combined therapy. The significantly enhances while enabling monitoring dynamic key biomarkers, solution for personalized adaptive precision

Language: Английский

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Lung-Targeted Delivery of PTEN mRNA Combined with anti-PD-1-mediated Immunotherapy for In Situ Lung Cancer Treatment

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy

Fundamental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Functional Nucleic Acid-based Fluorescence Imaging for Tumor Microenvironment Monitoring: A Review

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1350, P. 343794 - 343794

Published: Feb. 13, 2025

Language: Английский

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Boosting cuproptosis by activating JAK-STAT signaling pathway and synergrtic with interface-enhanced sonodynamic immunotherapy against cancer

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102701 - 102701

Published: March 15, 2025

Language: Английский

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Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 23, 2024

Chalcogens are used as sensitive redox-responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than internal environmental stimuli, enable site-directed and real-time drug degradation target lesions. This approach helps to bypass chemoresistance global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated hybrid monodisperse organosilica nanoprodrug based on homonuclear single (disulfide (S-S, approximately 240 kJ/mol), diselenium (Se-Se, 172 tellurium (Te-Te, 126 kJ/mol)), including ditelluride-bond-bridged MONs (DTeMSNs), diselenide-bond-bridged (DSeMSNs) disulfide-bond-bridged (DSMSNs). The results demonstrated that differences electronegativities atomic radii influenced their oxidation sensitivities reactivities. Tellurium, with the lowest electronegativity, showed highest sensitivity, followed selenium sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure X-rays, resulting TeO

Language: Английский

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Emerging Role of Extracellular pH in Tumor Microenvironment as a Therapeutic Target for Cancer Immunotherapy

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1924 - 1924

Published: Nov. 20, 2024

Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.

Language: Английский

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