Organic Letters,
Journal Year:
2024,
Volume and Issue:
27(1), P. 510 - 516
Published: Dec. 30, 2024
Capturing
CO2
is
highly
valued
in
the
field
of
organic
synthesis,
especially
underdeveloped
dual-CO2
conversion.
In
this
study,
we
detail
a
novel
reductive
cyclization
2-indolylanilines
with
dual
as
difunctional
reagent
presence
PMHS
[poly(methylhydrosiloxane)],
delivering
methyl-substituted
quinoxalines.
Furthermore,
another
chemoselective
2-pyrrolylanilines
also
realized
by
converting
mono-CO2.
Mechanistic
investigations
shed
light
upon
fact
that
substrate-controlled
divergence
mainly
depends
on
formation
N-diacylative
intermediates.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Direct
synthesis
of
enantioenriched
scaffolds
with
multiple
adjacent
stereocenters
remains
an
important
yet
challenging
task.
Herein,
we
describe
a
highly
diastereo-
and
enantioselective
Cu-catalyzed
alkylboration
cyclopropenes,
less
reactive
alkyl
iodides
as
electrophiles,
for
the
efficient
tetra-substituted
borylated
cyclopropanes
bearing
three
consecutive
stereocenters.
This
protocol
features
mild
conditions,
broad
substrate
scope,
good
functional
group
tolerance,
affording
array
chiral
in
to
high
yields
excellent
enantioselectivities.
Detailed
mechanistic
experiments
kinetic
studies
were
conducted
elucidate
reaction
pathway
rate-determining
step
reaction.
DFT
calculations
revealed
that
π···π
stacking
interaction
between
phenyl
groups
on
phosphorus
ligand,
along
smaller
distortion
CuL-Bpin
part,
contributed
The
synthetic
utility
was
showcased
by
facile
some
valuable
centers.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(22)
Published: March 26, 2024
Abstract
Upgrading
CO
2
to
value‐added
chiral
molecules
via
catalytic
asymmetric
C−C
bond
formation
is
a
highly
important
yet
challenging
task.
Although
great
progress
on
the
of
centrally
carboxylic
acids
has
been
achieved,
construction
axially
with
never
reported
date.
Herein,
we
report
first
synthesis
,
which
enabled
by
nickel‐catalyzed
dynamic
kinetic
reductive
carboxylation
racemic
aza‐biaryl
triflates.
A
variety
acids,
are
valuable
but
difficult
obtain
catalysis,
generated
in
an
enantioconvergent
version.
This
new
methodology
features
good
functional
group
tolerance,
easy
scale‐up,
facile
transformation
and
avoids
cumbersome
steps,
handling
organometallic
reagents
using
stoichiometric
materials.
Mechanistic
investigations
indicate
process
induced
nickel
catalysis.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(15), P. 3241 - 3246
Published: April 5, 2024
Herein,
we
report
an
electrochemical
protocol
for
the
dicarboxylation
of
aryl
alkynes
using
CO2.
With
a
graphite
rod
as
cathode
and
Al
sacrificial
anode,
series
valuable
butenedioic
acids
are
obtained
in
moderate
to
excellent
yields
with
E/Z
ratio
up
50:1.
This
method
features
high
E-selectivity,
step
atom
economy,
easy
scalability,
nice
substrate
scope,
which
renders
it
appealing
promising
applications
organic
synthesis
materials
chemistry.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 21, 2025
Carboxylation
with
CO2
offers
an
attractive
and
sustainable
access
to
valuable
carboxylic
acids.
Among
these
methods,
direct
C−H
carboxylation
of
terminal
alkynes
has
attracted
much
attention
for
one-carbon
homologation
alkynes,
enabling
rapid
synthesis
propiolic
In
contrast,
the
multi-carbons
construct
important
non-conjugated
alkynyl-containing
acids
not
been
reported.
Herein,
we
present
alkynylcarboxylation
alkenes
via
photoredox
copper
dual
catalysis.
This
protocol
provides
a
practical
method
form
alkynyl
from
readily
available
CO2.
Additionally,
this
approach
also
features
mild
(room
temperature,
1
atm
CO2)
redox-neutral
conditions,
high
atom
step
economy,
good
functional
group
tolerance,
selectivities.
Moreover,
diverse
transformations
β-alkynyl
acid
products
bioactive
molecule
(GPR40/FFA1
agonist)
further
illustrate
synthetic
utility
methodology.
The
report
multi-carbon
is
rare.
authors
catalysis,
affording
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Direct
carboxylation
of
C–H
bonds
with
CO2
represents
an
attractive
strategy
to
synthesize
valuable
carboxylic
acids
high
atom,
step,
and
redox
economy.
Although
great
progress
has
been
achieved
in
this
field,
catalytic
tertiary
C(sp3)–H
still
remains
challenging
due
their
inherent
inertness
significant
steric
hindrance.
Herein,
we
report
a
direct
benzylic
via
visible-light
photoredox
catalysis.
Various
all-carbon
quaternary
acids,
which
are
importance
medicinal
chemistry,
successfully
obtained
yields.
This
is
characterized
by
good
functional
group
tolerance,
broad
substrate
scope,
mild
operational
conditions.
Furthermore,
our
methodology
enables
the
efficient
rapid
synthesis
key
drug
or
bioactive
molecules,
such
as
carbetapentane,
caramiphen,
PRE-084
(σ1
receptor
agonist),
facilitates
various
functionalizations
C(sp2)–H
using
directing
ability
target
thus
highlighting
its
practical
applications.
Mechanistic
studies
indicate
that
carbanion,
serves
intermediate
react
CO2,
catalytically
generated
single
electron
reduction
radical
through
consecutive
photoinduced
transfer
process.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Aug. 16, 2024
Herein,
we
report
a
synergistic
photoredox/palladium
catalytic
system
for
the
efficient
enantioconvergent
synthesis
of
axially
chiral
esters
from
racemic
heterobiaryl
(pseudo)halides
(bromides/triflates)
with
CO
