Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
Abstract
Surface‐enhanced
resonance
Raman
scattering
(SERRS)
in
the
second
near‐infrared
(NIR‐II)
window
has
great
potential
for
improved
phototheranostics,
but
lacks
nonfluorescent,
resonant
and
high‐affinity
dyes.
Herein,
it
is
designed
synthesize
a
multi‐sulfur
reporter,
NF1064,
whose
maximum
absorption
of
1064
nm
rigidly
resonates
with
NIR‐II
excitation
laser
while
possessing
absolutely
nonfluorescent
backgrounds.
Ultrafast
spectroscopy
suggests
that
fluorescence
quenching
mechanism
NF1064
originates
from
twisted
intramolecular
charge
transfer
(TICT)
excited
state.
Gold
nanorods
(AuNRs)
decorated
such
(AuNR@NF1064)
show
remarkable
SERRS
performances,
including
zero‐fluorescence
background,
femtomolar‐level
sensitivity
as
well
superb
photostability
without
photobleaching.
More
importantly,
AuNR@NF1064
exhibits
nonlinear
photothermal
effect
upon
plasmonic
fields
AuNRs
by
amplifying
non‐radiative
decay
thus
achieving
high
conversion
68.5%
further
augmentation.
With
properties,
nanoprobes
allow
high‐precision
intraoperative
guided
tumor
resection
within
8
min,
high‐efficient
hyperthermia
combating
drug‐resistant
bacterial
infection
living
mouse
body.
This
work
not
only
unlocks
dyes
imaging,
also
opens
up
new
method
boosting
efficiency
nanomaterials.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
147(2), P. 2010 - 2020
Published: Jan. 7, 2025
Developing
small
organic
molecular
phototheranostic
agents
with
second
near-infrared
(NIR-II)
aggregation-induced
emission
(AIE)
is
paramount
for
the
phototriggered
diagnostic
imaging
and
synchronous
in
situ
therapy
of
cancer
via
an
excellent
balance
excited
states
energy
dissipations.
In
this
study,
a
multifunctional
iridium(III)
complex
exploited
by
coordination
AIE-active
N^N
ancillary
ligand
trivalent
iridium
ion.
The
resultant
DPTPzIr
significantly
outperforms
its
parent
terms
absorption/emission
wavelengths,
reactive
oxygen
species
(ROS)
production,
photothermal
conversion,
which
simultaneously
endow
nanoparticles
matched
absorption
peak
to
commercial
808
nm
laser,
longest
NIR-II
(above
1100
nm)
among
those
previously
reported
AIE
complexes,
potentiated
type-I
ROS
generation,
as
high
60.5%
conversion
efficiency.
Consequently,
perform
well
multimodal
image-guided
photodynamic
therapy-photothermal
breast
tumor-bearing
mice,
enabling
precise
tumor
diagnosis
complete
ablation
biocompatibility.
Our
present
work
provides
simple,
feasible,
effective
paradigm
development
advanced
agents.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: July 4, 2024
Abstract
Prostate‐specific
membrane
antigen
(PSMA)
is
known
to
be
overexpressed
in
prostate
cancer
(PCa).
The
development
of
precise
and
rapid
imaging
technologies
monitor
PSMA
crucial
for
early
diagnosis
therapy.
Fluorescence
the
second
near‐infrared
window
(NIR‐II)
has
emerged
as
a
powerful
tool
real‐time
tracking
vivo
visualization,
offering
high
sensitivity
resolution.
However,
there
lack
stable,
bright
easy‐to‐implement
NIR‐II
fluorescent
probes
targeting.
Herein,
we
presented
PSMA‐targeting
probe
FC‐PSMA
based
on
π‐conjugated
crossbreeding
dyed
strategy
that
affords
stability,
large
extinction
coefficient,
good
brightness.
As
demonstrated,
displayed
fluorescence
quantum
yield
fetal
bovine
serum
(FBS).
Following
intravenous
injection
FC‐PSMA,
tumor‐to‐normal
ratio
intensity
steadily
increased
over
time,
reaching
peak
at
48
h
(tumor‐to‐leg
=
12.16
±
0.90).
This
advancement
enables
identification
PC
through
imaging,
facilitating
high‐performance
guidance
resection
surgery.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Near-infrared
fluorescence
imaging
is
key
in
biological
exploration.
Short
emission
wavelengths
of
xanthene
dyes
limit
their
use.
Structural
modifications
shift
emissions
to
the
NIR-I/II
range,
enhancing
biomedical
applications.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
With
the
global
population
aging,
awareness
of
oral
health
is
rising.
Periodontitis,
a
widespread
bacterial
infectious
disease,
gaining
attention.
Current
novel
biomaterials
address
key
clinical
issues
like
infection,
gum
inflammation,
tooth
loosening,
and
loss,
focusing
on
antibacterial,
anti-inflammatory,
tissue
regeneration
properties.
However,
strategies
that
integrate
advantages
these
to
achieve
synergistic
therapeutic
effects
by
clearing
biofilms,
inhibiting
inflammation
activation,
restoring
periodontal
soft
hard
functions
remain
very
limited.
Recent
studies
highlight
link
between
periodontitis
systemic
diseases,
underscoring
complexity
disease.
There
an
urgent
need
find
comprehensive
treatment
plans
requirements.
Whether
integrating
new
enhance
existing
treatments
or
developing
approaches
replace
traditional
therapies,
efforts
will
drive
advancements
in
treatment.
Therefore,
this
review
compares
with
treatments.
It
highlights
design
concepts
mechanisms
functional
materials,
their
properties,
discusses
importance
strategies.
This
aims
provide
guidance
for
emerging
research
promote
development
precise
efficient
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Organic
afterglow
luminescence
can
emit
light
long
after
the
cessation
of
irradiation,
enabling
autofluorescence-free
in
vivo
imaging
with
high
signal-to-background
ratios
(SBRs).
Physical Chemistry Chemical Physics,
Journal Year:
2024,
Volume and Issue:
26(18), P. 14071 - 14078
Published: Jan. 1, 2024
To
achieve
the
effective
regulation
of
organic
room
temperature
phosphorescence
(RTP)
in
supramolecular
systems,
elucidation
host-guest
interactions
RTP
is
vital
importance.
Herein,
we
employed
two
dyes
(PYCl
and
PYBr)
their
four
complexes
with
CB[6]
CB[7]
explored
mechanism
interaction
induced
enhancement
using
quantum
mechanics/molecular
mechanics
(QM/MM)
approach.
For
dyes,
found
that
better
performance
PYBr
than
PYCl
attributed
to
intersystem
crossing
(ISC)
augmentation
by
heavy
atom
effect.
Binding
through
can
simultaneously
accelerate
radiative
decay
process
increasing
transition
dipole
moment
T
